Salicylic acid is a
phytochemical and a class of phenolic acid, belonging to the group of
Flavonoids (polyphenols), found a bundantly in peppermint, licorice, peanut, wheat, etc.
Health benefits
1. Comedonal Acne
In the comparison of lipohydroxyacid and salicylic acid peels in subjects with comedonal acne, found that there
was a statistically significant decrease of 55.6% and 48.5% from
baseline to Day 98 in the mean number of noninflammatory lesions for the
sides treated with lipohydroxyacid and salicylic acid
peels, respectively (P < 0.001). There was no significant
difference in the degree of reduction in noninflammatory lesions
between the two peels. There was no significant reduction in the number
of inflammatory lesions. Both peels were generally very well
tolerated, according to "Randomized trial comparing a chemical peel containing a lipophilic hydroxy acid derivative of salicylic acid with a salicylic acid peel in subjects with comedonal acne" by Levesque A, Hamzavi I, Seite S, Rougier A, Bissonnette R.(1)
2. Acne vulgaris
In
the evaluation of he efficacy and tolerability of the addition of SA
treatment to CDP and BPO (SA and CDP + BPO) and compare it with
CDP + BPO in patients with mild to moderate facial acne vulgaris.
found
that the addition of SA to CDP + BPO treatment demonstrated
significantly better and faster results in terms of reductions in acne lesion counts and well tolerated except for higher frequency of mild to moderate transient dryness, according to "Efficacy of the addition of salicylic acid to clindamycin and benzoyl peroxide combination for acne vulgaris" by Akarsu S, Fetil E, Yücel F, Gül E, Güneş AT.(2)
3. Breast cancer
In
the determination of the effect of aspirin on the incidence of breast
cancer metastasis, which is reported to occur in 50% of patients who
have previously received chemotherapy, radiation, and/or surgery, found
that ingestion of aspirin might significantly reduce the incidence of
breast cancer metastasis in patients who have previously received
anticancer therapies, according to "Acetyl salicylic acid (aspirin) improves synthesis of maspin and lowers incidence of metastasis in breast cancer patients [corrected]" by Bhattacharyya M, Girish GV, Ghosh R, Chakraborty S, Sinha AK.(3)
4. Anti-inflammatory effects
In
the examination of the mechanism whereby Methyl salicylate
2-O-b-D-lactoside (DL0309) exerts the anti-inflammatory effect, using
the model of lipopolysaccharide (LPS)-treated RAW264.7 cells, found
that DL0309 exerts anti-inflammatory effects, by inhibiting the
production of pro-inflammatory cytokines and suppressing of the
activation of NF-kB signaling pathway in LPS-treated macrophage cells.
Therefore, DL0309 may have therapeutic potential for treating
inflammatory diseases by regulating NF-κB pathway and pro-inflammatory
cytokine production, according to "A novel naturally-occurring salicylic acid analogue acts as an anti-inflammatory agent by inhibiting nuclear factor-kappaB activity in RAW264.7 macrophages" by Zhang T, Sun L, Liu R, Zhang D, Lan X, Huang C, Xin W, Wang C, Zhang DM, Du G.(4)
5. Antileukemia Activity
In the study, in vitro screen of a focused library of SH2 domain binding salicylic acid-containing
inhibitors (∼150) against STAT5, as well as against STAT3 and STAT1
proteins for SH2 domain selectivity, found that several potent (K(i)
< 5 μM) and STAT5 selective (>3-fold specificity for STAT5 cf.
STAT1 and STAT3) inhibitors, BP-1-107, BP-1-108, SF-1-087, and
SF-1-088. Lead agents, evaluated in K562 and MV-4-11 human leukemia
cells, showed potent induction of apoptosis (IC(50)'s ∼ 20 μM) which
correlated with potent and selective suppression of STAT5
phosphorylation, as well as inhibition of STAT5 target genes cyclin D1,
cyclin D2, C-MYC, and MCL-1. Moreover, lead agent BP-1-108 showed
negligible cytotoxic effects in normal bone marrow cells not expressing
activated STAT5 protein. Inhibitors identified in this study represent
some of the most potent direct small molecule, nonphosphorylated
inhibitors of STAT5 to date, according to "Small Molecule STAT5-SH2 Domain Inhibitors Exhibit Potent Antileukemia Activity" by Page BD, Khoury H, Laister RC, Fletcher S, Vellozo M, Manzoli A, Yue P, Turkson J, Minden MD, Gunning PT.(5)
6. Antioxidant and antimicrobial effects
In
the evaluation of the antioxidant and antimicrobial activities and
phenolic components of different solvent (absolute methanol, absolute
ethanol, absolute acetone, 80% methanol, 80% ethanol, 80% acetone and
deionized water) extracts of leaves, flowers and bark of Gold Mohar
found
that overall, 80% methanol extract produced from the leaves exhibited
significantly (P < 0.05) higher antioxidant activity, with high
phenolic contents (3.63 g GAE/100 g DW), total flavonoid contents (1.19 g
CE/100 g DW), inhibition of peroxidation (85.54%), DPPH scavenging
capacity (IC(50) value 8.89 μg/mL) and reducing power (1.87). Similarly,
this 80% methanol leaves extract also showed superior antimicrobial
activity. HPLC analysis of the 80% methanol extracts for individual
phenolics revealed the presence of gallic, protocatechuic and salicylic acid in leaves; gallic, protocatechuic, salicylic, trans-cinnamic and chlorogenic acid in flowers, and gallic acid
in bark as the main (amount > 1.50 mg/100 g DW) phenolic acids.
Besides, small amounts ( < 1.50 mg/100 g DW) of some other phenolic
acids such as sorbic, sinapic, p-coumaric, m-coumaric, ferulic, caffeic,
3-hydroxybenzoic, 4-hydroxycinnamic and 4-hydroxybenzoic acids were
also detected, according to "Antioxidant
and antimicrobial attributes and phenolics of different solvent
extracts from leaves, flowers and bark of Gold Mohar [Delonix regia
(Bojer ex Hook.) Raf]" by Shabir G, Anwar F, Sultana B, Khalid ZM, Afzal M, Khan QM, Ashrafuzzaman M.(6)
7. Antithrombotic effects
In
the evaluation of three different antithrombotic treatments in women
with antecedent of RPL, comparing the results in negative and positive
to thrombophilic screening pregnant women, found that all three
treatment regimens were significantly effective comparing live births
against fetal losses. In 87 positive to thrombophilic screening
pregnant women, the comparison of efficacy for the three regimens, shows
that the therapy with LMWH or LMWH plus ASA are significantly
protective against fetal losses with respect to ASA, which showed a high
number of fetal losses (11 live births, 18 fetal losses), according to
"Efficacy of three different antithrombotic regimens on pregnancy outcome in pregnant women affected by recurrent pregnancy loss" by Giancotti A, Torre RL, Spagnuolo A, D'Ambrosio V, Cerekja A, Piazze J, Chistolini A.(7)
8. Facial flat warts
In the evaluation of the efficacy and safety of glycolic acid 15% topical gel plus salicylic acid
2% in the treatment of recalcitrant facial flat warts, found that All
the patients were clinically cured within eight weeks. Seven patients
cleared in four weeks, and 13 patients cleared in eight weeks. No
noticeable adverse events were related to the skin, according to "Glycolic Acid 15% plus salicylic Acid 2%: a new therapeutic pearl for facial flat warts" by Rodríguez-Cerdeira C, Sánchez-Blanco E.(8)
9. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21896127
(2) http://www.ncbi.nlm.nih.gov/pubmed/22035285
(3) http://www.ncbi.nlm.nih.gov/pubmed/20670296
(4) http://www.ncbi.nlm.nih.gov/pubmed/22292506
(5) http://www.ncbi.nlm.nih.gov/pubmed/22148584
(6) http://www.ncbi.nlm.nih.gov/pubmed/22143540
(7) http://www.ncbi.nlm.nih.gov/pubmed/21988715
(8) http://www.ncbi.nlm.nih.gov/pubmed/21938272
No comments:
Post a Comment