Caffeic acid is a organic
phytochemical of the class of hydroxycinnamic acid, found in all
plants, including burdock, hawthorn, artichoke, pear, basil, thyme,
oregano, apple, etc.
Health Benefits
1. Liver cancer
In the studies of cancer chemoprevention with caffeic acid phenethyl ester
(CAPE) in the resistant hepatocyte model of hepatocarcinogenesis,
indicated that microsomal assays demonstrated that CAPE interfered with
DEN activation diminishing nitrites similar to SKF525A and probably
mediated by CYP2B1/2 inhibition. A single dose of CAPE before DEN
treatment reduced the appearance of tumors by 43%, according to "Cancer Prevention Mediated by Caffeic Acid Phenethyl Ester Involves Cyp2b1/2 Modulation in Hepatocarcinogenesis" by Beltrán-Ramírez O, Macías Pérez R, Sierra-Santoyo A, Villa-Treviño S.(1)
2. Antioxidant Effect
In
the testing the antioxidant properties of hydroalcoholic (HAB) and
aqueous extracts (AB) from the bark and aqueous extract (AL) from the
leaves of Stryphnodendron rotundifolium to determine a possible
association between antioxidant activity and the popular use of this
plant,
found that gallic acid, catechin, rutin and caffeic acid were
the major components of the crude extracts of S. rotundifolium. Plant
extracts inhibited Fe(II)-induced lipid peroxidation in brain
homogenates. Iron chelation was also investigated and only HBA
exhibited a weak activity. Taken together, the results suggest that S.
rotundifolium could be considered an effective agent in the prevention
of diseases associated with oxidative stress, according to "Antioxidant
Effect of Stryphnodendron rotundifolium Martius Extracts from
Cariri-Ceará State (Brazil): Potential Involvement in Its Therapeutic
Use" by Costa JG, Leite Gde O, Dubois AF, Seeger RL, Boligon AA, Athayde ML, Campos AR, Rocha JB.(2)
3. Neurodegenerative effects
In
the investigated Neuroprotective effect of CAPE in rat organotypic
midbrain slice cultures and in vivo experimental mouse model of
dopaminergic neurodegeneration by intranigral injection of
lipopolysaccharide (LPS) and intrastriatal injection of
6-hydroxydopamine, found that neuroprotective effect of CAPE against
LPS-induced injury was prevented by zinc protoporphyrin IX or anti-BDNF
antibody. CAPE protected dopaminergic neurons and alleviated
methamphetamine-induced rotational behavior also in 6-hydroxydopamine
hemi-parkinsonian mice, according to "Caffeic acid
phenethyl ester protects nigral dopaminergic neurons via dual
mechanisms involving heme oxygenase-1 and brain-derived neurotrophic
factor" by Kurauchi Y, Hisatsune A, Isohama Y, Mishima S, Katsuki H.(3)
4. Immunoregulatory effects
In
the study of PBMCs from asthmatic children (5.5 ± 3.3 years old, n=28)
and healthy children (5.6 ± 2.8 years old, n=23) were co-cultured with
CAPE in vitro with and without
phorbol-12-myristate-13-acetate-ionomycin, found that he
immunoregulatory effects of CAPE on human PBMCs may be through the
induction of regulatory T cells, as evidenced by the enhanced
transforming growth factor-beta 1 production from PBMCs from asthmatic
children in our study, according to "The immunoregulatory effects of caffeic Acid phenethyl ester on the cytokine secretion of peripheral blood mononuclear cells from asthmatic children" by Sy LB, Yang LK, Chiu CJ, Wu WM.(4)
5. Antioxidant, anti-glycation and anti-inflammatory activities
In
the investigation of 9 compounds isolated from the ethyl acetate
soluble fraction of C. sinensis, namely protocatechuic acid (1), trans-caffeic acid
(2), methyl rosmarinate (3), rosmarinic acid (4),
kaempferide-3-O-β-D-glucopyranoside (5),
kaempferol-3-O-β-D-glucopyranoside (6),
quercetin-3-O-β-D-glucopyranoside (7),
kaempferide-3-O-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (8) and
kaempferol-3-O-α-L-rhamno-pyranosyl (1→6)-β-D-glucopyranoside (9) for
biological activity and showed significant anti-inflammatory activity in
the carrageen induced rat paw edema test and the antioxidant activities
of isolated compounds 1-9 were evaluated by the DPPH radical
scavenging test, and compounds 1, 2, 4 and 7-9 exhibited marked
scavenging activity compared to the standard BHA. These compounds were
further studied for their anti-glycation properties and some compounds
showed significant anti-glycation inhibitory activity, according to "Antioxidant, anti-glycation and anti-inflammatory activities of phenolic constituents from Cordia sinensis" by Al-Musayeib N, Perveen S, Fatima I, Nasir M, Hussain A.(5)
6. Acute Chlamydia pneumoniae Infection
In the investigation of whether corn mint, a good source of natural phenols such as flavone glycosides and caffeic acid
derivatives, extract would be beneficial against a universal
respiratory tract pathogen, Chlamydia pneumoniae, infection, found that
Linarin completely inhibited the growth at 100 μM. Inbred C57BL/6J mice
were inoculated with C. pneumoniae K7. M. arvensis extract was given
intraperitoneally once daily for 3 days prior to inoculation and
continued for 10 days postinfection. The extract was able to diminish
the inflammatory parameters related to C. pneumoniae infection and
significantly (p = 0.019) lowered the number of C. pneumoniae genome
equivalents detected by PCR at biologically relevant amounts, according
to "Corn Mint ( Mentha arvensis ) Extract Diminishes Acute Chlamydia pneumoniae Infection in Vitro and in Vivo" by Salin O, Törmäkangas L, Leinonen M, Saario E, Hagström M, Ketola RA, Saikku P, Vuorela H, Vuorela PM.(6)
7. Male Fertility
In
the assessment of the adverse effect of lambda cyhalothrin (LC) on
reproductive organs and fertility in male rats and the protective role
of caffeic acid
phenethyl ester (CAPE), found that treatment with CAPE improved the
reduction in the sperm characteristics, LC-induced oxidative damage of
testes and the testicular histopathological alterations. Results
indicate that LC exerts significant harmful effects on the male
reproductive system and that CAPE reduced the deleterious effects of LC
on male fertility, according to "Protective role of caffeic acid on lambda cyhalothrin-induced changes in sperm characteristics and testicular oxidative damage in rats" by Abdallah FB, Fetou H, Zribi N, Fakhfakh F, Keskes L.(7)
8. Anti-HIV Activity
In
the sudy of the phytochemical properties and anti-HIV activity of the
phenolic isolates of the plateau medicinal plant DAPHNE ACUTILOBA Rehd.
(Thymelaeceae), found that daphnenin ( 1) and caffeic acid
N-octadecyl ester ( 13) showed definite anti-HIV activity with EC (50)
values of 0.39 and 0.16 µg/mL, respectively, according to "Phenols with Anti-HIV Activity from Daphne acutiloba" by Huang SZ, Zhang XJ, Li XY, Jiang HZ, Ma QY, Wang PC, Liu YQ, Hu JM, Zheng YT, Zhou J, Zhao YX.(8)
9. Antihypertensive effect
In
the investigation of the antihypertensive effect of Melothria
maderaspatana leaf fractions on deoxycorticosterone acetate
(DOCA)-salt-induced hypertensive rats and identification of compounds
from the active fraction by GC-MS analysis, found that by GC-MS
analysis, phytochemicals such as coumarin, vallinic acid, p-coumaric
acid, gallic acid, caffeic acid,
and ferulic acid were identified in EAFM. In conclusion, the EAFM
controls blood pressure in DOCA-salt hypertensive rats and reverts the
metabolic alterations in magnesium, copper and zinc., according to "Antihypertensive
effect of Melothria maderaspatana leaf fractions on DOCA-salt-induced
hypertensive rats and identification of compounds by GC-MS analysis" by Veeramani C, Al-Numair KS, Chandramohan G, Alsaif MA, Alhamdan AA, Pugalendi KV.(9)
10. Etc.
Chinese Secrets To Fatty Liver And Obesity Reversal
Use The Revolutionary Findings To Achieve
Optimal Health And Loose Weight
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
Back to Popular Herbs http://kylejnorton.blogspot.ca/p/popular-herbs.html
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22291063
(2) http://www.ncbi.nlm.nih.gov/pubmed/22258340
(3) http://www.ncbi.nlm.nih.gov/pubmed/22224485
(4) http://www.ncbi.nlm.nih.gov/pubmed/22192260
(5) http://www.ncbi.nlm.nih.gov/pubmed/22158590
(6) http://www.ncbi.nlm.nih.gov/pubmed/22073967
(7) http://www.ncbi.nlm.nih.gov/pubmed/22025501
(8) http://www.ncbi.nlm.nih.gov/pubmed/21989641
(9) http://www.ncbi.nlm.nih.gov/pubmed/21964566
No comments:
Post a Comment