Friday, 22 November 2013

Phytochemicals and Narcolepsy

Narcolepsy is a sleep disorder of excessive sleepiness even attacks at the daytime.

Types of foods to prevent and treat Narcolepsy
1. Low-carbohydrate, ketogenic diet (LCKD)
In the study of the effects of a low-carbohydrate, ketogenic diet (LCKD) on sleepiness and other narcolepsy symptoms, showed that the Narcolepsy Symptom Status Questionnaire (NSSQ)-Total score decreased by 18% from 161.9 to 133.5 (p = 0.0019) over 8 weeks. Patients with narcolepsy experienced modest improvements in daytime sleepiness on an LCKD(1).

2.  Coffee
In the study to evaluate the wake-promoting efficacy of paraxanthine, caffeine, and a reference wake-promoting compound, modafinil, in a mice model of narcolepsy, showed that Paraxanthine, caffeine, and modafinil significantly promoted wakefulness in both WT and narcoleptic TG mice and proportionally reduced NREM and REM sleep in both genotypes. The wake-promoting potency of 100 mg/kg p.o. of paraxanthine during the light period administration roughly corresponds to that of 200 mg/kg p.o. of modafinil. The wake-promoting potency of paraxanthine is greater and longer lasting than that of the equimolar concentration of caffeine, when the drugs were administered during the light period(2).

3. Salmon (Tyrosine: 1168mg)
In the study of L-tyrosine in the treatment of narcolepsy, researchers indicated that Since the precursor of dopamine is L-tyrosine, the administration of this amino acid may prove beneficial in the treatment of narcolepsy(3).

4. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/15210901
(2) http://www.ncbi.nlm.nih.gov/pubmed/20614853
(3) http://www.ncbi.nlm.nih.gov/pubmed/2090930

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