Friday, 22 November 2013

Phytochemicals and Jaundice

Jaundice is a condition of yellowish pigmentation of the skin and the whites of the eye as a result of either the body is producing too much, or not getting rid of bilirubin in the fat layer under the skin fast enough due to conditions of liver or gallbladder.

Types of food to prevent and treat Jaundice
1. Broccoli and spinach
Alpha-lipoic acid is found abundantly in Broccoli and spinach, In the study to assess the Application of alpha-lipoic acid in clinical practice,  found that LA was shown to be hepatoprotective, to improve liver circulation and treat chronic liver diseases, including jaundice hepatitis, cirrhosis, and hepatic coma, to treat diabetes, and diabetic neuropathy to alter carbohydrate metabolism, atherosclerosis, coronary atherosclerosis and many others diseases(1).

2. Sweet lime peel
In the study to evaluate the role of bilirubin as an antioxidant in neonatal jaundice patients, showed that the ethanolic extract of sweet lime peel, administered orally at a dose of 72 microg is found to reduce the oxidative stress in erythrocytes of phenylhydrazine-induced jaundiced rats treated with phototherapy(2).

3. Guduchi, ginger and barley
in the study to assess the hepatoprotective effects of Melatonin and extract of Tinospora cordifolia in bile duct ligation induced jaundice in rats, showed that the assessment of microscopy, lab tests and the measurement of oxidative stress products indicates a marked hepatoprotective effect of those two compounds. The results allowed us to recomand the use of melatonin and Tinospora cordifolia to reduce the cholestasis's oxidative stress in human(3)

4. Ligularia fischeri
Ligularia fischeri is a well-known edible medicinal herb in Korea. In the study of antihepatotoxic effects of Ligularia fischeri var. spiciformis and the identification of the active component, 3,4-dicaffeoylquinic acid, researchers at the Kyungsung University, indicated that DCQA is a major principle for the antihepatotoxic activity of L. fischeri var. spiciformis. DCQA also partially restored bile flow and reduced total bilirubin and cholic acid concentrations in rats with ANIT-induced cholestasis. Treatment with DCQA inhibited the increase in triglyceride, cholesterol, and total lipids in DL-ethionine-induced fatty liver. These results support the traditionally held belief that this plant can be used for the treatment of jaundice and hepatic failure(4).

5. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22768734
(2) http://www.ncbi.nlm.nih.gov/pubmed/19374257
(3) http://www.ncbi.nlm.nih.gov/pubmed/21698863
(4) http://www.ncbi.nlm.nih.gov/pubmed/16176146

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