Friday, 22 November 2013

Phytochemicals and Graves' disease

Graves' disease is defined as a condition of auto immune diaereses causes of over active thyroid of that lead to over production of thyroid hormone.

Types of food to prevent and treat Graves' disease 
1. Orange juices (vitamin C), soybean (vitamin E), carrot (Beta carrotene) and Brazil nut (Selenium)
In the study to investigate the effect of supplementation with a fixed combination of antioxidants (vitamins C and E, beta-carotene and selenium) was monitored on the speed of attaining euthyroidism in a group of patients with Graves' disease, treated with methimazole, showed that Patients who received supplementation with antioxidants in addition to therapy with methimazole (Group A, n=29) attained euthyroidism faster than the patients treated with only methimazole (Group B, n=28). The concentration of selenium in the serum of patients in Group A increased significantly during treatment (p<0.001), while there was no statistically significant change in the patients in Group B. The concentration of selenium in the serum between the groups differed statistically significantly 30 days (p<0.05) and 60 days (p<0.01) after the commencement of therapy. Activity of glutathione peroxidase in whole blood increased during treatment in both groups of patients. However, a statistically more significant increase occurred in Group A compared to Group B, 30 days after the commencement of therapy (p<0.01)(1).

2. Soy
In the study to investigate the effect of quercetin in primary cultured orbital fibroblasts from GO, targeting pathways of inflammation, aberrant accumulation of extracellular matrix macromolecules, and adipose tissue expansion. showed that Treatment with noncytotoxic doses of quercetin inhibited accumulation of intracytoplasmic lipid droplets and resulted in a dose-dependent decrease in expression of peroxisome proliferator-activated receptor γ, CCAAT/enhancer-binding protein (C/EBP) α, and C/EBPβ proteins. In conclusion, inhibition of inflammation, hyaluronan production, and adipogenesis by the natural plant product quercetin in vitro provides the basis for further study of its potential use in the treatment of GO(2).

3. Asparagus and Tomato (tocopherols) and sesame seeds (coenzyme Q)
In the study to clarify the different roles of free radical scavenging systems in various thyroid disorders, we measured the levels of alpha-, beta-, and gamma-tocopherols and coenzyme Q in the thyroid tissues of patients with thyroid tumors and Graves' disease using high-performance liquid chromatography, showed that the level of coenzyme Q was reduced in the thyroid tissue of patients with Graves' disease and follicular and papillary thyroid carcinomas. These findings imply that vitamin E and coenzyme Q as scavengers play some role in thyroid follicular cell hyperfunction or dysfunction(3).

4. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/14967159
(2) http://www.ncbi.nlm.nih.gov/pubmed/22039452
(3) http://www.ncbi.nlm.nih.gov/pubmed/9537635

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