Duodenal ulcers, a type of peptic ulcer is defined as a
condition of a localized tissue erosion in the lining the duodenum as a
result of bacteria Helicobacter pylori (H pylori) in most cases.
According to the study by Department of Research, University Hospital,
Basel, fasting gastrin and pepsinogen-I and -II concentrations were
significantly higher in H pylori positive compared with H pylori
negative subjects. Neither age nor sex affected basal gastrin and
pepsinogen concentrations in H pylori negative subjects. Fasting
gastrin, pepsinogen-I and -II concentrations in serum samples were
similar in H pylori positive persons with no symptoms and those with
duodenal ulcers suggesting that similar mechanisms are involved in
increasing plasma concentrations of these variables in both populations.
Hypergastrinaemia and hyperpepsinogenaemia are therefore probably
secondary to active H pylori.
D. Preventions
D.3. Phytochemicals to prevent Duodenal ulcers
Plants and phytoconstituents are the better choice to treat
diseases than the allopathic drugs. Most of the drugs used in primitive
medicine were originated from plants and are the earliest and principal
natural source of medicines. The drugs from plants are fairly innocuous
and relatively free from toxic effects(22).
1. Fructans
Fructans found abundantly in onion, are small carbohydrate molecules
that help maintain gastrointestinal health by sustaining beneficial
bacteria(23).
2. Phenols
Polyphenols display a number of pharmacological properties in the GIT
area, acting as antisecretory, cytoprotective, and antioxidant agents.
The antioxidant properties of phenolic compounds have been widely
studied, but it has become clear that their mechanisms of action go
beyond the modulation of oxidative stress. Various polyphenolic
compounds have been reported for their anti-ulcerogenic activity with a
good level of gastric protection(24). Other indicated that the
antimicrobial activity was greater in extract mixtures than in
individual extracts of each species. The results also indicate that the
synergistic contribution of oregano and cranberry phenolics may be more
important for inhibition than any species-specific phenolic
concentration(25).
3. Anthocyanins
Edible berries, a potential source of natural anthocyanin antioxidants,
have demonstrated a broad spectrum of biomedical functions. In the study
by InterHealth Research Center, showed that OptiBerry exhibits high
antioxidant efficacy as shown by its high oxygen radical absorbance
capacity (ORAC) values, novel antiangiogenic and antiatherosclerotic
activities, and potential cytotoxicity towards Helicobacter pylori, a
noxious pathogen responsible for various gastrointestinal disorders
including duodenal ulcer and gastric cancer, as compared to individual
berry extracts. OptiBerry also significantly inhibited basal MCP-1 and
inducible NF-kappabeta transcriptions as well as the inflammatory
biomarker IL-8, and significantly reduced the ability to form hemangioma
and markedly decreased EOMA cell-induced tumor growth in an in vivo
model(26).
4. Triterpenes
In study of the extracted isolation of Eugenia umbelliflora Berg.
(Myrtaceae): taraxerol, alpha-amyrin, beta-amyrin, betulin and betulinic
acid from the leaves, as well as trimethoxy ellagic acid from the
fruitshe extracts of Eugenia umbelliflora Berg. (Myrtaceae), found that
E. umbelliflora leaves display gastro-protective activity, as
demonstrated by significant inhibition of ulcer formation in the
different models. The results suggest that the gastroprotective activity
may be attributed, at least in part, to the triterpenes(27).
5. Etc.
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Sources
(22) http://onions-usa.org/img/site_specific/uploads/phytochemical_brochure.pdf
(23) http://onions-usa.org/img/site_specific/uploads/phytochemical_brochure.pdf
(24) http://www.ncbi.nlm.nih.gov/pubmed/21966156
(25) http://www.ncbi.nlm.nih.gov/pubmed/16332847
(26) http://www.ncbi.nlm.nih.gov/pubmed/17533652
(27) http://www.ncbi.nlm.nih.gov/pubmed/19731591
Health Researcher and Article Writer. Expert in Health Benefits of Foods, Herbs, and Phytochemicals. Master in Mathematics & Nutrition and BA in World Literature and Literary criticism. All articles written by Kyle J. Norton are for information & education only.
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