Eriodictyol is a Flavanones,
belonging to the flavonoid in Flavonoids extracted from Yerba Santa,
twigs of Millettia duchesnei and certain types of fruit and herb.
Health Benefits
1. Cytoprotective effect
In the study of exact of eriodictyol and its molecular mechanism of the cellular effects found that t eriodictyol
may lead to protection of keratinocytes from UV-induced cytotoxicity
by modulating both the p38 MAPK and Akt signaling pathways in a
phosphatase-dependent manner, according to "Cytoprotective effect of eriodictyol in UV-irradiated keratinocytes via phosphatase-dependent modulation of both the p38 MAPK and Akt signaling pathways" by Lee ER, Kim JH, Choi HY, Jeon K, Cho SG.(1)
2. Anti-apoptotic and anti-oxidant effect
In
the investigation of 10 different flavonoids and assessed their role
on UV-induced apoptosis of human keratinocytes, the principal cell type
of epidermis found that eriodictyol
treatment apparently reduced the percentage of apoptotic cells and the
cleavage of poly(ADP-ribose) polymerase, concomitant with the
repression of caspase-3 activation and reactive oxygen species (ROS)
generation. The anti-apoptotic and anti-oxidant effects of eriodictyol were also confirmed in UV-induced cell death of normal human epidermal keratinocyte (NHEK) cells, according to "The anti-apoptotic and anti-oxidant effect of eriodictyol on UV-induced apoptosis in keratinocytes" by Lee ER, Kim JH, Kang YJ, Cho SG.(2)
3. Anti-inflammatory effects
In
the evaluation of the suppression of lipopolysaccharide (LPS)-induced
inflammatory responses in macrophages among the four similar structure
flavonoids found that pre-treatment of Raw 264.7 cells with eriodictyol
reduced the expression of mRNA and the secretion of pro-inflammatory
cytokines. These inhibitory effects were found to be caused by blockage
of nuclear factor kappa-light-chain-enhancer of activated B cells
(NF-κB) activation and phosphorylation of p38 mitogen-activated protein
kinase (MAPK), extracellular signal-regulated kinases 1 and 2 (ERK1/2)
and c-Jun N-terminal kinase (JNK), according to "Anti-inflammatory effects of eriodictyol in lipopolysaccharide-stimulated raw 264.7 murine macrophages" by Lee JK.(3)
4. Capillary electrophoresis
In the investigation of separation of five flavanones and flavanone-7-O-glycosides, including naringenin, hesperetin, eriodictyol,
homoeriodictyol, isosakuranetin, and hesperidin and their effect in
α-Cyclosophoro-octadecaoses (α-C18), produced by Rhodobacter sphaeroides
found that successful chiral separation critically depends on the
presence of succinate substituents attached to α-C18 in CE, suggesting
that succinoylation of α-C18 is decisive for effective stereoisomeric
separation, according to "Stereoisomeric
separation of some flavanones using highly succinate-substituted
α-cyclosophoro-octadecaoses as chiral additives in capillary
electrophoresis' by Kwon C, Jung S.(4)
5. Neoplastic cell transformation
In the demonstration oferiodictyol, a flavanone found in fruits and its suppresses EGF-induced neoplastic cell transformation found that eriodictyol
inhibited phosphorylation of ATF1 but had no effect on the
phosphorylation of RSK, MEK1/2, ERK1/2, p38 or JNKs, indicating that eriodictyol specifically suppresses RSK2 signaling. Furthermore, eriodictyol inhibited RSK2-mediated ATF1 transactivation and tumor promoter-induced transformation of JB6 Cl41 cells. Eriodictyol or knockdown of RSK2 or ATF1 also suppressed Ras-mediated focus formation, according to "Eriodictyol inhibits RSK2-ATF1 signaling and suppresses EGF-induced neoplastic cell transformation" by Liu K, Cho YY, Yao K, Nadas J, Kim DJ, Cho EJ, Lee MH, Pugliese A, Zhang J, Bode AM, Dong Z, Dong Z.(5)
6. Antiproteasomal agent
In
the study of flavanone glycoside and flavone glycoside compounds and
their Antiproteasomal effect found that kaempferol, a well known and
widely distributed flavonoid in the plant kingdom, was the most active
antiproteasomal agent, followed by apigenin, eriodictyol-7-O-β-D-glucuronopyranoside, 3,5-dihydroxyphenethyl alcohol-3-O-β-D-glucopyranoside, and salidroside, respectively, according to "Phenolic Glycosides with antiproteasomal activity from Centaurea urvillei DC. subsp. urvillei" by Gülcemal D, Alankuş-Çalışkan O, Karaalp C, Ors AU, Ballar P, Bedir E.(6)
7. Melanogenesis
In
the investigation of phytochemicals and their effect in Melanogenesis
found that isolated, anastatin A, silybin A, isosilybins A and B, eriodictyol,
luteolin, kaempferol, quercetin, hierochins A and B,
(2R,3S)-2,3-dihydro-2-(3,4-dimethoxyphenyl)-3-hydroxymethyl-5-(2-formylvinyl)-7-hydroxybenzofuran,
(+)-dehydrodiconiferyl alcohol, (+)-balanophonin,
1-(4-hydroxy-3-methoxyphenyl)-2-{4-[(E)-3-hydroxy-1-propenyl]-2-methoxyphenoxy}-1,3-propanediol,
and 3,4-dihydroxybenzaldehyde substantially inhibited melanogenesis
with IC(50) values of 6.1-32 microM, according to "Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells" by Nakashima S, Matsuda H, Oda Y, Nakamura S, Xu F, Yoshikawa M.(7)
8. Antimicrobial effect
In
the research of flavonoids extracted from bergamot (Citrus bergamia
Risso) peel and its antimicrobial potency found that pairwise
combinations of eriodictyol,
naringenin and hesperetin showed both synergistic and indifferent
interactions that were dependent on the test indicator organism,
according to "Antimicrobial activity of
flavonoids extracted from bergamot (Citrus bergamia Risso) peel, a
byproduct of the essential oil industry" by Mandalari G, Bennett RN, Bisignano G, Trombetta D, Saija A, Faulds CB, Gasson MJ, Narbad A.(8)
9. Antiplatelet activity
In the investigation of ethanol summary extract and four flavonoids from Leuzea carthamoide, including eriodictyol (1) and patuletin (2) influenced COL- and AA-induced aggregation. Their IC(50) values are presented. Flavonoid glycosides eriodictyol-7-beta-glucopyranoside
(3) and 6-hydroxykaempferol-7-O-(6''-O-acetyl-beta-D[small
cap]-glucopyranoside) (4) and their antiplatelet activity found that
found to be weak antiplatelet agents. These results confirmed the fact
that glucosylation decreases the antiplatelet activity. according to "In vitro antiplatelet activity of flavonoids from Leuzea carthamoides" by Koleckar V, Brojerova E, Rehakova Z, Kubikova K, Cervenka F, Kuca K, Jun D, Hronek M, Opletalova V, Opletal L.(9)
10. Protozoan infection
In the evaluation of Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids found that Antiplasmodial activity of eriodictyol
and luteolin is reported here for the first time. Besides, the four
compounds showed activity against P. falciparum 3D7 strain and
Trypanosoma brucei rhodesiense, according to "Triterpenic acids and flavonoids from Satureja parvifolia. Evaluation of their antiprotozoal activity" by van Baren C, Anao I, Leo Di Lira P, Debenedetti S, Houghton P, Croft S, Martino V.(10)
11. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21691069
(2) http://www.ncbi.nlm.nih.gov/pubmed/17202655
(3) http://www.ncbi.nlm.nih.gov/pubmed/21544733
(4) http://www.ncbi.nlm.nih.gov/pubmed/21093852
(5) http://www.ncbi.nlm.nih.gov/pubmed/21098035
(6) http://www.ncbi.nlm.nih.gov/pubmed/20937505
(7) http://www.ncbi.nlm.nih.gov/pubmed/20189399
(8) http://www.ncbi.nlm.nih.gov/pubmed/18045389
(9) http://www.ncbi.nlm.nih.gov/pubmed/18161506
(10) http://www.ncbi.nlm.nih.gov/pubmed/16729575
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