During the last stage of the menstrual cycle normally a layer of
endometriosis lining in the inside of the uterus is expelled, known as
menstruation blood but instead some of the endometriosis tissues growing
somewhere in the body causing endometriosis. Endometriosis also reacts
to hormonal signals of the monthly menstrual cycle by building up
tissue, breaking it, and eliminating it through the menstrual period. In
this article, we will discuss what is what is
GnRH(gonadotrophin-releasing hormone) agonists??
I. Definition
GnRH is a hormone released by the hypothalamus which stimulates the
pituitary to produce luteinising hormones (LH) and follicle that
stimulate hormone (FSH) to drive a menstrual cycle.
II. Effectiveness of GnRH
Just likes progesterone-like agonists, GnRH ( gonadotrophin-releasing
hormone) have been used in treating endometriosis for more than 20
years. They come in different forms: three-monthly injection, monthly
injection, daily injection and nasal spray because of their chemical
make up. GnRH are natural hormone blocking medicines, they help to stop
the ovulation and create a temporary menopause state.
Study shows that GnRH are effective in reducing the symptoms and the
size of endometrial implants but unfortunately, symptoms tend to return
after stopping treatment in 4 months.
III. The Good
1) It helps to induce a menopause state, thereby reducing symptoms of menstrual cramps.
2.) It also uses to treat heavy menstruation, if other drugs failed.
3) Ovulation usually comes back within a month of stopping the drugs.
4) Reduce symptoms and sizes of endometrial implants because the drug creates the menopause state and stop the ovulation.
5) It can be given as an injection one a month or nostril spray.
6) Endometrial implants may be returned back to it original size within a few months after stop taking the medicine.
III. Risks
1. Loss of bone density
Loss of bone density is normal for women taking the GnRH drug. Since it
causes menopause state, it deplete the calcium in the body that is
essential for building a healthy bone. It also distorts the ratio of
magnesium and calcium.
2) Reducing sexual desire
Sexual libido may be caused by dry vagina, one of many symptoms of GnRH.
It may also be caused by low level of estrogen that is essential for
driving sexual desire.
3) Increase the risk of developing of ovarian cysts.
IV. Side effects
a) Hot flush, dry vagina caused by temporary of menopause state.
b) Loss of libido caused by low level of estrogen and vagina dryness.
c) Loss of bone density caused by low level of estrogen and progesterone.
d) Nutritional deficiency caused by symptoms of menopause state as our
body is no longer absorb magnesium and calcium effectively.
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