Tuesday, 26 November 2013

Duodenal ulcers Treatments In traditional Chinese medicine perspective

 Duodenal ulcers, a type of peptic ulcer is defined as a condition of a localized tissue erosion in the lining  the duodenum as a result of bacteria Helicobacter pylori (H pylori) in most cases. According to the study by Department of Research, University Hospital, Basel, fasting gastrin and pepsinogen-I and -II concentrations were significantly higher in H pylori positive compared with H pylori negative subjects. Neither age nor sex affected basal gastrin and pepsinogen concentrations in H pylori negative subjects. Fasting gastrin, pepsinogen-I and -II concentrations in serum samples were similar in H pylori positive persons with no symptoms and those with duodenal ulcers suggesting that similar mechanisms are involved in increasing plasma concentrations of these variables in both populations. Hypergastrinaemia and hyperpepsinogenaemia are therefore probably secondary to active H pylori.
F. Treatments 
In traditional Chinese medicine perspective
In the study to investigate whether the tongue inspection technique in Traditional Chinese Medicine (TCM) can be used as a noninvasive auxiliary diagnostic tool to differentiate the subtypes of peptic ulcer disease (PUD) and as an indicator of therapeutic efficacy, found that the color of the tongue body did not change in the cured patients; however, tongue fur was markedly thinner with a color change to white (p<0.05), while sublingual veins with engorgement (p<0.05) and blood stasis (p<0.01) improved after the ulcer healed and Hp was eradicated and concluded that TCM tongue inspection can be potentially used as a noninvasive auxiliary diagnostic method and as an indicator for clinical outcomes for patients with PUD(37).

1. Hai Gui Yu Yang capsule
In the study to assess the efficacy and safety of haiguiyuyang capsule in the treatment of duodenal ulcer (also diagnosed as weiwan pain and hanrecuoza syndrome according to the theory of TCM), researchers found that the efficacy of haiguiyuyang capsule in treating duodenal ulcer is similar to that of ranitidine. No obvious adverse effect of it was observed in this trial(38).
2. Kang Wei Granules
Kang Wei Granules, a granular preparation for strengthening the spleen and replenishing Qi and for clearing away heat and resolving dampness, was used in the treatment of 288 cases of gastropathy related to Helicobacter pylori infection. The effects were compared with De Nol triple therapy in the control group of 74 cases. The therapeutic results showed that Kang Wei Granules was superior to the western drugs in improving the principal symptoms of deficiency of the spleen and stomach, and retention of damp-heat in the interior (P < 0.05), according to the study by Beijing TCM Institute(39).
3. Yu Yang powder
In the study of two hundreds patients of peptic ulcer diagnosed by fiber-gastroscope treated with Yuyang powder (YYP) and to compare with patient treated with cimetidine for control, showed that the curative rate of YYP on peptic ulcer was 88.1%, the total effective rate was 96%, similar to that of cimetidine. But the difference of recurrence rate (19.1% for YYP and 46% for control) between the two groups was very significant. Animal experiment revealed that the protective action of YYP with high dosis on gastric mucosa in peptic ulcer and gastritis was superior to that of cimetidine, its has the double effect of both strengthening protective factors and weakening aggressive factors of gastric mucosa(40).
4. Bushen kangkui decoction
The clinical controlled study of Bushen Kangkui Decoction (BSKKD) on 150 peptic ulcer patients showed that it had a similar effect to injectio cimetidine, and had a lower rate of relapse. And the long-term therapeutic effect was better than that of injectio cimetidine, according to the study by Yichun People’s Hospital(41).
5. Wei Yang An (easing peptic-ulcer) capsule)
Tthe effects of the two are similar, but the long-term effect of Wei Yang An was better. Wei Yang An was also good for most cimetidine resistant ulcers, with few side effect. Animal experiment showed that Wei Yang An inhibited the ulcers, according to the study by Hunan Institute of Gerontology(42).
6. Etc.

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