Duodenal ulcers, a type of peptic ulcer is defined as a
condition of a localized tissue erosion in the lining the duodenum as a
result of bacteria Helicobacter pylori (H pylori) in most cases.
According to the study by Department of Research, University Hospital,
Basel, fasting gastrin and pepsinogen-I and -II concentrations were
significantly higher in H pylori positive compared with H pylori
negative subjects. Neither age nor sex affected basal gastrin and
pepsinogen concentrations in H pylori negative subjects. Fasting
gastrin, pepsinogen-I and -II concentrations in serum samples were
similar in H pylori positive persons with no symptoms and those with
duodenal ulcers suggesting that similar mechanisms are involved in
increasing plasma concentrations of these variables in both populations.
Hypergastrinaemia and hyperpepsinogenaemia are therefore probably
secondary to active H pylori.
F. Treatments
In traditional Chinese medicine perspective
In the study to investigate whether the tongue inspection technique in
Traditional Chinese Medicine (TCM) can be used as a noninvasive
auxiliary diagnostic tool to differentiate the subtypes of peptic ulcer
disease (PUD) and as an indicator of therapeutic efficacy, found that
the color of the tongue body did not change in the cured patients;
however, tongue fur was markedly thinner with a color change to white
(p<0.05), while sublingual veins with engorgement (p<0.05) and
blood stasis (p<0.01) improved after the ulcer healed and Hp was
eradicated and concluded that TCM tongue inspection can be potentially
used as a noninvasive auxiliary diagnostic method and as an indicator
for clinical outcomes for patients with PUD(37).
1. Hai Gui Yu Yang capsule
In the study to assess the efficacy and safety of haiguiyuyang capsule
in the treatment of duodenal ulcer (also diagnosed as weiwan pain and
hanrecuoza syndrome according to the theory of TCM), researchers found
that the efficacy of haiguiyuyang capsule in treating duodenal ulcer is
similar to that of ranitidine. No obvious adverse effect of it was
observed in this trial(38).
2. Kang Wei Granules
Kang Wei Granules, a granular preparation for strengthening the spleen
and replenishing Qi and for clearing away heat and resolving dampness,
was used in the treatment of 288 cases of gastropathy related to
Helicobacter pylori infection. The effects were compared with De Nol
triple therapy in the control group of 74 cases. The therapeutic results
showed that Kang Wei Granules was superior to the western drugs in
improving the principal symptoms of deficiency of the spleen and
stomach, and retention of damp-heat in the interior (P < 0.05),
according to the study by Beijing TCM Institute(39).
3. Yu Yang powder
In the study of two hundreds patients of peptic ulcer diagnosed by
fiber-gastroscope treated with Yuyang powder (YYP) and to compare with
patient treated with cimetidine for control, showed that the curative
rate of YYP on peptic ulcer was 88.1%, the total effective rate was 96%,
similar to that of cimetidine. But the difference of recurrence rate
(19.1% for YYP and 46% for control) between the two groups was very
significant. Animal experiment revealed that the protective action of
YYP with high dosis on gastric mucosa in peptic ulcer and gastritis was
superior to that of cimetidine, its has the double effect of both
strengthening protective factors and weakening aggressive factors of
gastric mucosa(40).
4. Bushen kangkui decoction
The clinical controlled study of Bushen Kangkui Decoction (BSKKD) on 150
peptic ulcer patients showed that it had a similar effect to injectio
cimetidine, and had a lower rate of relapse. And the long-term
therapeutic effect was better than that of injectio cimetidine,
according to the study by Yichun People’s Hospital(41).
5. Wei Yang An (easing peptic-ulcer) capsule)
Tthe effects of the two are similar, but the long-term effect of Wei
Yang An was better. Wei Yang An was also good for most cimetidine
resistant ulcers, with few side effect. Animal experiment showed that
Wei Yang An inhibited the ulcers, according to the study by Hunan
Institute of Gerontology(42).
6. Etc.
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