Huai Hua Mi or Hoai Jiao is also known as Pagodatree Flower. The bitter and cold herb has been used in TCM treat nose bleeding, blood in stool, blood in urine, bleeding of hemorrhoids, diarrhea with blood, bleeding in vagina not during menses, hypertension, carbuncles, gangrene, etc., as it cools Blood, stops bleeding, etc., by enhancing the functions of liver and large intestine channels.
Ingredients
1. Kaempferol 3-O-β-glucopyranosyl(1 → 2)-β-galactopyranoside-7-O-α-rhamnopyranoside
2. Kaempferol 3-O-β-xylopyranosyl(1 → 3)-α-rhamnopyranosyl(1 → 6)[β-glucopyranosyl(1 → 2)]-β-glucopyranoside,
3. kaempferol 3-O-β-glucopyranosyl(1 → 2)[α-rhamnopyranosyl(1 → 6)]-β-glucopyranoside-7-O-α-rhamnopyranoside
4. Kaempferol 3-O-β-glucopyranosyl(1 → 2)[α-rhamnopyranosyl(1 → 6)]-β-galactopyranoside-7-O-α-rhamnopyranoside
5. Etc.
Health Benefits
1. Anti-adipogenic effects
In the elucidation of the possible mechanisms for the anti-obesity action of S. japonica L. and its effects on adipocyte differentiation investigated in C3H10T1/2 mesenchymal stem cells and 3T3-L1 preadipocyte cells, found that the polyphenols in the ethyl acetate (EtOAc) fractions mediated the anti-adipogenic effects. Finally, high-performance liquid chromatography identified genistein, a known anti-adipogenic compound, as the probable mediator of the anti-adipogenic effects of the EtOAc fractions. This work validates the beneficial roles of S. japonica L. in controlling body weight and obesity-related metabolic diseases, according to “Genistein mediates the anti-adipogenic actions of Sophora japonica L. extracts” by
Jung SR, Kim YJ, Gwon AR, Lee J, Jo DG, Jeon TJ, Hong JW, Park KM, Park KW.(1)
2. Pulmonary fibrosis
In the assessment of the effect of oxymatrine on pulmonary fibrosis, using a bleomycin-induced pulmonary fibrosis mouse mode, showed that bleomycin challenge provoked severe pulmonary fibrosis with marked increase in hydroxyproline content of lung tissue and lung fibrosis fraction, which was prevented by oxymatrine in a dose-dependent manner. In addition, bleomycin injection resulted in a marked increase of myeloperoxidase activity and malondialdehyde level that was attenuated by oxymatrine, according to ‘Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture” by Chen X, Sun R, Hu J, Mo Z, Yang Z, Liao D, Zhong N.(2)
3. Anti-platelet effects
In the evaluation of the anti-platelet effects of the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10) from a methanol extract of Sophora japonica, indicated that among the compounds, 1, 3, and 7 showed approximately 2.5-6.5 fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation (IC50: 19.9 and 99.8 microM; 20.3 and 53.8 microM; 25.9 and 123.4 microM, respectively) than acetylsalicylic acid (ASA, IC50: 63.0 and 350.0 microM). Compound 2 was an approximately 22-40 fold stronger inhibitor than ASA on AA and U46619 induced aggregation (IC50: 1.6 and 15.6 microM, respectively), according to ” Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica” by Kim JM, Yun-Choi HS.(3)
4. Anti Obesity
In the elucidation of the possible mechanisms for the anti-obesity action of S. japonica L., its effects on adipocyte differentiation were investigated in C3H10T1/2 mesenchymal stem cells and 3T3-L1 preadipocyte cells, found that The EtOAc fraction extracts inhibited morphological differentiation and lipid accumulation in the C3H10T1/2 and 3T3-L1 preadipocytes. Molecular studies indicated that the EtOAc fraction extracts also reduced the expression of peroxisome proliferator-activated receptor γ and other adipocyte markers. Furthermore, among the fractions, the EtOAc fraction extracts had the highest total phenolic contents, suggesting that the polyphenols in the EtOAc fractions mediated the anti-adipogenic effects, according to “Genistein mediates the anti-adipogenic actions of Sophora japonica L. extracts” by
In the assessment of the effect of oxymatrine on pulmonary fibrosis, using a bleomycin-induced pulmonary fibrosis mouse mode, showed that bleomycin challenge provoked severe pulmonary fibrosis with marked increase in hydroxyproline content of lung tissue and lung fibrosis fraction, which was prevented by oxymatrine in a dose-dependent manner. In addition, bleomycin injection resulted in a marked increase of myeloperoxidase activity and malondialdehyde level that was attenuated by oxymatrine, according to ‘Attenuation of bleomycin-induced lung fibrosis by oxymatrine is associated with regulation of fibroblast proliferation and collagen production in primary culture” by Chen X, Sun R, Hu J, Mo Z, Yang Z, Liao D, Zhong N.(2)
3. Anti-platelet effects
In the evaluation of the anti-platelet effects of the isolation of four flavonoids and six flavonoid-glycosides: biochanin A (1), irisolidone (2), genistein (3), sissotrin (4), sophorabioside (5), genistin (6), tectoridin (7), apigenin (8), quercitrin (9), and rutin (10) from a methanol extract of Sophora japonica, indicated that among the compounds, 1, 3, and 7 showed approximately 2.5-6.5 fold greater inhibitory effects on arachidonic acid (AA) and U46619 induced platelet aggregation (IC50: 19.9 and 99.8 microM; 20.3 and 53.8 microM; 25.9 and 123.4 microM, respectively) than acetylsalicylic acid (ASA, IC50: 63.0 and 350.0 microM). Compound 2 was an approximately 22-40 fold stronger inhibitor than ASA on AA and U46619 induced aggregation (IC50: 1.6 and 15.6 microM, respectively), according to ” Anti-platelet effects of flavonoids and flavonoid-glycosides from Sophora japonica” by Kim JM, Yun-Choi HS.(3)
4. Anti Obesity
In the elucidation of the possible mechanisms for the anti-obesity action of S. japonica L., its effects on adipocyte differentiation were investigated in C3H10T1/2 mesenchymal stem cells and 3T3-L1 preadipocyte cells, found that The EtOAc fraction extracts inhibited morphological differentiation and lipid accumulation in the C3H10T1/2 and 3T3-L1 preadipocytes. Molecular studies indicated that the EtOAc fraction extracts also reduced the expression of peroxisome proliferator-activated receptor γ and other adipocyte markers. Furthermore, among the fractions, the EtOAc fraction extracts had the highest total phenolic contents, suggesting that the polyphenols in the EtOAc fractions mediated the anti-adipogenic effects, according to “Genistein mediates the anti-adipogenic actions of Sophora japonica L. extracts” by
Jung SR, Kim YJ, Gwon AR, Lee J, Jo DG, Jeon TJ, Hong JW, Park KM, Park KW.(4)
5. Cerebral infarction
In an overview of the effects of Sophora japonica on cerebral infarction based on literature searched from Medline, PubMed,showed that Sophora japonica reduces cerebral infarction partly as a result of its anti-oxidative and anti-inflammatory activities. Previous studies found that Sophora japonica reduced the size of cerebral infarction and neurological deficits and reduced microglial activation, interleukin-1β release and number of apoptotic cells in ischemia-reperfusion injured Sprague-Dawley rats, according to “Effects of Sophora japonica flowers (Huaihua) on cerebral infarction” by Chen HN, Hsieh CL.(5)
6. Antihyperglycemic activity
In the investigation of the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats, found that after 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls, according to “Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats” by Jung CH, Zhou S, Ding GX, Kim JH, Hong MH, Shin YC, Kim GJ, Ko SG.(6)
7. Etc.
In an overview of the effects of Sophora japonica on cerebral infarction based on literature searched from Medline, PubMed,showed that Sophora japonica reduces cerebral infarction partly as a result of its anti-oxidative and anti-inflammatory activities. Previous studies found that Sophora japonica reduced the size of cerebral infarction and neurological deficits and reduced microglial activation, interleukin-1β release and number of apoptotic cells in ischemia-reperfusion injured Sprague-Dawley rats, according to “Effects of Sophora japonica flowers (Huaihua) on cerebral infarction” by Chen HN, Hsieh CL.(5)
6. Antihyperglycemic activity
In the investigation of the effects of herb extracts, Rhus verniciflua, Agrimonia pilosa, Sophora japonica, and Paeonia suffruticosa, on the lowering of blood glucose levels and thiobarbituric acid reactive substances (TBARS) in streptozotocin (STZ)-induced diabetic rats, found that after 4 weeks, oral administration of Rhus verniciflua extract (50 mg/kg) exhibited a significant decrease in blood glucose levels in diabetic rats (P<0.05). Blood TBARS concentrations, the products of glucose oxidation in blood, were also lowered by Rhus verniciflua extract supplementation. In addition, Sophora japonica and Paeonia suffruticosa extracts significantly reduced TBARS levels versus diabetic controls, according to “Antihyperglycemic activity of herb extracts on streptozotocin-induced diabetic rats” by Jung CH, Zhou S, Ding GX, Kim JH, Hong MH, Shin YC, Kim GJ, Ko SG.(6)
7. Etc.
Side Effects
1. Do not use the Huai Hua Mi in newborn, children or if you are
pregnant or breast feedign with out approval first with the related
field specialist2. Hoai Hua Mi may cause anaphylactic reaction in children
3. Etc.
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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21303259
(2) http://www.ncbi.nlm.nih.gov/pubmed/18684219
(3) http://www.ncbi.nlm.nih.gov/pubmed/18704331
(4) http://www.ncbi.nlm.nih.gov/pubmed/21303259
(5) http://www.cmjournal.org/content/5/1/34
(6) http://www.ncbi.nlm.nih.gov/pubmed/17031059
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