Chinese Herbs– Bai Hua She She Cao (herba hedyotidis Diffusae)

Bai Hua She She Cao also known as spreading hedyotis, the bitter, sweet and cold herb has been used in TCM as anti-bacteria, anti-inflammation, anti-tumor, anti-virus medicine and to enhance immune system, treat toxic sores, ulcerations, swellings, snake bites, sore throat, bronchitis, tonsillitis, and hemorrhoids, etc., as it enhances Clears Heat, Drains Dampness, Expels toxins, Resolves abscesses by enhancing the functions of liver, stomach, large intestine channels. Ingredients
1. E-6-0-P(E-6-0-p-coumaroyl scandoside methyl ester
2. P-coumaric acid
3. Oleanolic acid
4. Trans p-coumaric acid
5. Ursolic acid
6. Sitosterol
7. β-sitosterol
8. Flavone
9. β-sitosterol-D-glucose
10. Hentriacontane
11. Etc.

Health Benefits
1. Anti Cancer
Hedyotis Diffusa Willd (Bai Hia She She Cao) extract had inhibited tumor angiogenesis by promoting cancer cell apoptosis via activation of the mitochondrial-dependent pathway with little side effects, according to the study of “Effect of Hedyotis Diffusa Willd extract on tumor angiogenesis” by Lin J, Wei L, Xu W, Hong Z, Liu X, Peng J., posted in PubMed(1).
2. Leukemia
Isolated splenocytes from HDW extract has demonstrated an increase of T- and B-cell proliferation in treating leukemic mice, in vivo, according to the study of “Extract of Hedyotis diffusa Willd influences murine leukemia WEHI-3 cells in vivo as well as promoting T- and B-cell proliferation in leukemic mice” by Lin CC, Kuo CL, Lee MH, Hsu SC, Huang AC, Tang NY, Lin JP, Yang JS, Lu CC, Chiang JH, Chueh FS, Chung JG., posted in PubMed(2)
3. Breast Cancer
Methylanthraquinone from Hedyotis diffusa WILLD have induced MCF-7 cells (a breast cancer cell line)apoptosis via Ca(2+)/calpain/caspase-4 pathway, according to the study of
“Methylanthraquinone from Hedyotis diffusa WILLD induces Ca(2+)-mediated apoptosis in human breast cancer cells” by Liu Z, Liu M, Liu M, Li J., posted in PubMed(3)
4. Colon cancer
Hedyotis Diffusa Willd extract has exerted the activity of inducing apoptosis of colon cancer cell line via activation of the mitochondrion-dependent pathway, according to the study of “Hedyotis Diffusa Willd extract induces apoptosis via activation of the mitochondrion-dependent pathway in human colon carcinoma cells” by Lin J, Chen Y, Wei L, Chen X, Xu W, Hong Z, Sferra TJ, Peng J., posted in PubMed(4)
5. Anti colon, liver and lung cancer
Hedyotis diffusa Willd. (Rubiaceae) has demonstrated the activity of inhibition of cell growth and induction of cell apoptosis in COLO 205 (colon cancer), Hep 3B (hepatocellular carcinoma) and H460 (lung cancer) cell lines., due to its chemical compound ursolic aci, according to the study of “Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa” by Lee HZ, Bau DT, Kuo CL, Tsai RY, Chen YC, Chang YH., posted in PubMed(5)
6. Etc.
Side effects
1. Bai Hua She She Cao may cause allergic reactions of discomfort and rash and itches and sever of breathing difficulty to certain people.
2. Do not use if you are pregnant or breast feeding without approval of your doctor or related field of specialist
3. Etc.

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(1) http://www.ncbi.nlm.nih.gov/pubmed/21887465
(2) http://www.ncbi.nlm.nih.gov/pubmed/21709007
(3) http://www.ncbi.nlm.nih.gov/pubmed/19686834
(4) http://www.ncbi.nlm.nih.gov/pubmed/20878081
(5) http://www.ncbi.nlm.nih.gov/pubmed/21213409