Sunday, 24 November 2013

Allergies - Pet Allergy

Allergy is the over reaction of immune system to harmless substances after entering our body affecting 1 in every 3 people.

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Allergy is defined as the type I reactions or Immediate Hypersensitivity as a result ofover production of Immunoglobulin E (IgE), a class of allergic antibody by the immune system against harmless substance that lead to mediated release of histamine and other mediators from mast cells and basophils, resulting in allergic reaction, including mucus secretion, sneezing, itching, etc.

I. Pet Allergy
Pet allergy is defined as a condition of over reaction of the immune system when a person if exposed one or more of the five known allergens produced by pets. in fact, most pet allergens are actually proteins in the saliva of animals.

I.1. How to determine the severity of the allergic effects
Depending to the allergy stimulating effect, some researchers suggested to scale the severity from 1 to 4 and followed by degeneration scale, but from -1 to -4
I.1.1. The severity scale from +1 to +4
+1. The first level of stimulation
If there is no symptoms at all or If the patient is alert and function morally after exposing to pet
+2. The second level of stimulation
The patient have become irritable, hyperactive, tense, thirsty, etc. after exposure
+3. The third level of stimulation
The patient have become hypomanic, aggressive, apprehensive, etc.+4. The fourth level of stimulation
The patient have become mania, agitation, over excitement, etc.

I.1.2. Degeneration scale from -1 to -4
-1. If a patient is experience symptoms of reaction of runny nose, hive, diarrhea, etc.
-2. If a patient is experience symptoms of reaction of tiredness, fatigue, swelling etc.
-3. If a patient is experience symptoms of reaction of depression, mental disturbance, confusion, mood change, etc.
-4. If a patient is experience symptoms of reaction of sever depression, paranoia, etc.

I.2. Symptoms
Symptoms are the result in nasal congestion, due to pet allergens cause of a chain reaction that leads the mast cells in these tissues to release histamine, causing dilation of many small blood vessels in the nose and swelling to nasal pathway of which can affects the daily activity including quality of life, productivity, and other chronic conditions, including asthma.In the study of "Bronchial Allergen Challenge Using the Medicaid Dosimeter" by Schulze J, Rosewich M, Dressler M, Riemer C, Rose MA, Zielen S. (Source from Department of Allergy, Pulmonology and Cystic Fibrosis, Children's Hospital, Goethe-University, Frankfurt a.M., Germany. posted in PubMed, researchers suggested that The use of aerosol provocation system to calculate the PD(20)FEV(1) allergen is a time saving procedure and is less prone to errors because only one dilution of the allergen is used. The repeatability in well-defined subjects is excellent to study the mechanisms of allergen-induced airway inflammation and the development of new treatments for allergic diseases.
1. Asthma-like symptoms
2. Itching
3. Sneezing
4. Wheezing
5. Sinus pain
6. Tearing eyes
7. Runny nose
8. Itchy eyes and throat
9. Etc.

I.3. Diagnosis
If you are experience Pet Allergy, it is possible to find what types of allergen have trigger that. After recording the family history and a complete physical exam. you doctor may order
1. Skin test
a. Intradermal test
It is one of most common test but time consuming (some patient may return for more 20 time for the injection) in diagnosis of allergy and depending to the symptoms, by injecting small amounts of diluted allergens into the top layers of the skin to see how the immune system react to them.
b. Skin prick testing
Similar to the Intradermal test, but the diagnosis involves in applying a drop of allergen into to punctures made on the skin.

2. Blood test (RadioAllergoSorbent Test)
This is the test for evaluating of the levels of IgE-mediated food allergies react to a particular allergen. If you RAST score is higher than the predictive value, 95% chance you will have an allergic reaction. Unfortunately, non-IgE mediated allergies cannot be detected by this method.

3. Challenge Tests
Because of the risk of anaphylaxis, most doctors will avoid the test unless it is absolutely necessary and the test is performed only in the hospital. In this test, suspected allergen package into capsule taken by patient and signs or symptoms of an allergic reaction are observed.

4. Etc.

I. 3. Prevention
There is no way to prevent them unless you can prevent yourself from exposure to pet. But one can always enhance the immune system by eating healthy and living a healthy lifestyle. For more information of healthy foods, visit 100+ Healthy Foods Classification

I.5. Treatments
I.5.1. Conventional medicineAccording to the study of "Human allergy to environmental pet danders: a public health perspective" by Morris DO. (Source from
Department of Clinical Studies - Philadelphia, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St., Philadelphia, PA 19104, USA., © 2010 The Author. Journal compilation © 2010 ESVD and ACVD), posted in PubMed, researcher found that The literature regarding primary and secondary exposures in different ambient environments is explored including threshold effects that influence allergen sensitization and elicitation of symptoms, and environmental intervention strategies that seek to reduce allergen exposure. Pet-specific factors, including the aetiopathogenesis of the several cat and dog allergens that have been characterized to the molecular level, individual animal characteristics that influence Fel d 1 and Can f 1 shedding, and pet-directed interventions intended to reduce allergen dispersal, are discussed.
1. There is no specific treatment for Pet allergy, but depending to the symptoms. Medication includes bronchodilators, anti-allergics, antihistamines, NSAIDs, etc.

2. Allergic shot
Allergy shot, also known as immunotherapy, contains extracts from the most common substance which people are allergic to, including pollen, insects, pets, etc., by providing long-term relief from certain symptoms. In some people, after series of allergic shot, the disease is cured.

3. Etc.

I.5.2. Herbs1. Panax Ginseng
In a study of "Effects of Red Ginseng extract on allergic reactions to food in Balb/c mice." by Sumiyoshi M, Sakanaka M, Kimura Y. (Division of Functional Histology, Department of Functional Biomedicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan.) posted in US National Library of Medicine National Institutes of Health, researchers suggested that It may also protect against sensitization to antigens as an immunomodulator by increasing intestinal IgA secretion without affecting antigen-specific IgE levels.

2. Garlic
It is best known for treating cold and flu and enhances immune system against alll types of foreign invasion. According to the study of "Immunomodulatory Effects of Aged Garlic Extract"
Eikai Kyo, Naoto Uda, Shigeo Kasuga and Yoichi Itakur, Posted in the "Journal of Nutrition" in March 2001, researchers strongly suggest that AGE (Aged Garlic Extract) could be a promising candidate as an immune modifier, which maintains the homeostasis of immune functions; further studies are warranted to determine when it is most beneficial.

3. Butterbur
Butterbur has been used over thousand of years in herbal medicine in treating symptoms of allergy, including to treat coughs,, asthma, stress, muscle relaxant, etc..According to the article of "Allergy" posted in The University of Michigan health System, the article indicated Two double-blind studies have compared butterbur extract to standard antihistamine drugs in people with hay fever. The first compared it with the drug cetirizine (Zyrtec) and found the drug and butterbur extract relieved symptoms equally well. However, cetirizine caused significantly more adverse effects, including a high rate of drowsiness.The second study compared butterbur extract with fexofenadine (Allegra) and placebo. Butterbur extract was as effective as fexofenadine at relieving symptoms, and both were significantly better than placebo.

4. Ginkgo leaves
Ginkgo leaves contain ginkgolides, which inhibit platelet-activating factor cause of asthma and allergies. according to the study of "Ginkgolides Antagonizing Some Effects of Platelet-activating Factor in Vitro" vy Dong JC, Li M, Shi ZY (Huashan Hospital, Shanghai Medical University) posted in, researchers found that exposure of guinea pigs' bronchus to PAF in vitro resulted in a loss of beta-adrenergic receptors and responses to isoproterenol, and this effect of PAF was prevented by prior incubation of the guinea pigs' bronchus with ginkgolides (P < 0.05). The results showed ginkgolides were a potent PAF antagonist.

5. Etc.

I.5.3. Traditional Chinese MedicineIn a study of "Complementary and alternative medicine in pediatric allergic disorders." by Li XM. (Source from Department of Pediatrics, Mount Sinai School of Medicine, New York, NY, USA., posted in PubMed, researcher indicated that in the last 2-3 years, there have been more controlled studies of TCM for allergic asthma and allergic rhinitis. Several publications including ours indicate that some TCM herbal formulas are well tolerated and produce some level of efficacy. Some herbal formulas also showed beneficial immunomodualtory effects. Several preclinical studies demonstrated that the food allergy herbal formula-2 was effective in protecting against peanut anaphylaxis in animal models. Two TCM products have entered clinical trials in the United States for treating asthma and food allergy, respectively. Both of these trials include children. In Summary, researcher concluded that Recent studies indicate that TCM therapy including herbal medicines and acupuncture for allergic disorders in children is well tolerated. There are also promising clinical and objective improvements. More controlled clinical studies are encouraged.
1. Xin Yi Hua is a lily-shaped flower with a hairy bud and Xin-yi-san (Magnolia Flower Powder)a. It is a type of traditional Chinese medicine used to treat allergy and dramatically reduces the symptoms of sneezing, anosmia, nasal congestion and profuse rhinorrhea (runny nose) caused by allergies triggered by dust mites, pets and fungi.According to the study of "Traditional Chinese medicine, Xin-yi-san, reduces nasal symptoms of patients with perennial allergic rhinitis by its diverse immunomodulatory effects" bySien-Hung Yang, Chia-Li Yu, Ying-Lin Chen, Sheng-Lin Chiao, Mei-Ling Chen f. Posted in International Immunopharmacology 10 (2010) 951–958, researchers found that this proposal is based on the fact that different combinations of Chinese herbs involve different mechanisms. It appears that the immunosuppressive and anti-inflammatory effects derived from the mixed formula of Chinese herbs are broader than XYS. Nevertheless,we found that XYS alone sufficiently exerts immunomodulatory effects on patients with AR.In conclusion, this study provides evidence to support that XYS, when used singly, is beneficial in nasal allergic inflammation through enhancing IL-10 and IL-8 production.
b. Ingredient
Main use: Expels wind-cold, unblocks nasal passages, congestion, loss of smell, sinus headache.

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