Whole Food Ginger, the Stroke Prevention Functional Remedy

By Kyle J. Norton


Stroke is a medical condition characterized by the death of brain cells as a result of inadequate of oxygen-rich blood flow.

In other words, stroke can be caused by either ischemia, due to lack of blood flow or hemorrhagia, due to bleeding.

A stroke is a medical emergency. Early intervention in most cases can minimize brain damage and potential complications.

According to the statistics, in the US, stroke is the leading cause of serious, long-term disability.
Each year, approximately 795,000 people suffer a stroke and recurrent stroke. Most cases of stroke are associated with adults over the age of 65.

Not all strokes can lead to permanent brain damage. Some people with a temporary disruption of blood flow to the brain do not result in permanent damage.

Besides aging, smoking, medical conditions such as unmanaged high blood pressure and cholesterol and diabetes, obesity, physical inactivity are some of the prevalent factors found in stroke patients.

Some researchers suggested a poor diet pattern such as the Western diet may have a strong impact in elevated the risk of stroke in the Western world.

Dr. Sherzai A, the lead scientist wrote, " Stroke is the fourth leading cause of mortality in the United States, yet it is 80% preventable by addressing lifestyle factors including nutrition".

And, "Adherence to DASH, Mediterranean, and prudent dietary patterns reduced the risk of stroke, whereas the Western dietary pattern was associated with increased stroke risk".

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

With an aim to find a natural whole food for reducing the risk of stroke researchers examined the effects of ginger in the risk of stroke.

Three candidates from the ginger family identified based on the prediction models in the study were compared to those of the control inhibitor L-454560.

PDE4D inhibitor is a potential drug target used in stroke prevention.

Administration of 3 compounds identified from the ginger family was capable in inhibiting cAMP binding associated with the increase of stroke risk, similar to those of PDE4D.

Genetic polymorphisms of PDE4D (T83C, C87T, and C45T) gene is associated with increased risk of ischemic stroke (IS).

Genetic polymorphisms of ALOX5AP are also associated with ischemic stroke and atherothrombotic events in stroke patients.

In order to reveal more information about ginger anti-stroke risk activity, researchers examined the ginger on the activities of phosphodiesterase 4D (PDE4D) and 5-Lipoxygenase activating protein (ALOX5AP), the two of the major factors involved in the ischemic stroke, accounting for around 80-85% of total stroke.

Injection of ginger not only modulated the expression of PDE4D activities against the activation of cAMP-induced stroke and cardiovascular diseases but also inhibited the overexpression of ALOX5AP that could induce the development of atherosclerosis and stroke through inflammatory pathways.

Take all together, ginger may be considered a functional alternative for the prevention of stroke, pending to the confirmation of large sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

Sources

(1) In silico pharmacology suggests ginger extracts may reduce stroke risks by Chang TT1, Chen KC, Chang KW, Chen HY, Tsai FJ, Sun MF, Chen CY. (PubMed)
(2) Traditional Chinese medicine, a solution for reducing dual stroke risk factors at once? by Chen KC1, Chang KW, Chen HY, Chen CY. (PubMed)
(3) Stroke, food groups, and dietary patterns: a systematic review by Sherzai A1, Heim LT, Boothby C, Sherzai AD. (PubMed)

The 46 Amazing Health Benefits of Fennel, According to Medical Literature

By Kyle J. Norton

Fennel is a species of Foeniculum Vulgare, belonging to the family Apiaceae (Umbelliferae), native to the shores of the Mediterranean. It is now widely cultivated all around the globe to use as food and herb.

Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc

Chemical constituents
1. 1,3-benzenediol
2. 1-methoxycyclohexene
3. O-cymene
4. Sorbic acid,
5. 2-hydroxy-3-methyl-2-cyclopenten-1-one
6. Estragole
7. Limonene-10-ol
8. 3-methyl-2-cyclopenten-1-one
9. Linoleic acid
10. Oleic acid
11. Undecanal
12. 2,4-undecadienal
13. trans-Anethole
14. Fenchone
15. Limonene
1. Infectious Diseases: The Natural Antibiotics Alternative With No Side Effects
2. Food therapy - Fennel as antioxidants
3. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Irritable Bowel Syndrome 
4. Food Therapy: Fennel and it's Bioactive Anethole in Attenuated Risk, Progression and Treatment of Periodontitis (PD) 
5.  Food Therapy: Fennel or Its Composition as Laxative Agent for Treatment of Chronic Constipation 
6. Food Therapy: Fennel In Attenuated Risk, Progression and Treatment of Intestinal Dysbiosis 
7. Food Therapy: Fennel In Ameliorated Risk, Progression and Treatment of Breast Cancer 
8. Herbal Therapy: Fennel, A Potent Functional Food for Treatment of Infantile Colic 
9. Herbal Therapy: The Best of Perennially Herbal.Fennel In Ameliorated Risk, Progression and Treatment of Prostate cancer
10. Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period 
11. Food Therapy; Fennel Seeds, A Potent Galactogenisis in Increased Milk Secretion in Lactation Period 
12.  Herbal Therapy: Fennel In Reduced Symptoms and Treatment of Estrogenic Deficiency Related Diseases
13. Eat Fennel to Inhibit Daily Stress in the Workplaces, Scientists Suggested
14. Women’s Health: Protect DNA Integrity Against Breast Cancer with This Single Herb, Online Medical Literature Revealed
15. Food Therapy: Intake Fennel to Optimize the Digestive Functioning in absorbed Nutrients and Fluids
16. Food Therapy: Fennel The Potent Food With Cytoprotection and Antitumor Activity 
17. Food Therapy: Fennel and Its Extracts in Detoxed Body Toxins, According to PubMed Online Literature
18. Herbal Therapy: Fennel, A Potent Chemo-Preventive and Modulatory Functional Herb
19. Fennel May Improve Your Heart Functioning Naturally and Permanently, Studies Showed 
20. How to Treat Painful Primary Dysmenorrhea Quickly and Permanently, According to PubMed 
21. 325. Fennel Seed Extracts That Gobble Up Toxins Caused by Drug Interaction and Toxicity, Scientists Show
22. Fennel, The Best Herbal Remedy Which Detoxes Your Kidneys Through Promoting Excess Fluids Secretion, Public Medical Library Reveal
23. Fennel, The Herbal Remedy Which Protects Our Body Against The Onset of Acute Inflammation and Chronic Inflammatory Diseases, Scientists Find
34. Fennel, A Potent Neurons Protective and Memory Enhancing Functional Herb
35. Fennel, The Reliable and Less Expensive Functional Food For Treatment of Hirsutism
36. Detoxification: Fennel, The Potent and Functional Food Which Protects the Liver Against Toxicity
37. Fennel, The Functional Herb Which Processes Anti Anxiolytic Property Similar to Those of Diazepam with No Adverse Effects, Scientists Find
38. Fennel, The Natural Remedy Which Protects the Brain Neurons Against The Onset of Cognitive Impairment, Scientists Suggest
39. Fennel, the Functional Herb Which Processes Anti-antispasmodic Activity, Scientists Find
40. Fennel, the Best Functional Food Which Processes Anti Hypolipidemic Activity
41. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
42. Fennel, The Herb Which Causes the Apoptosis of Cancer Cells, Scientists Find
43. Fennel, a Natural Anti Fever Functional Food
44. Fennel, The Natural Free Radical Scavenger, Scientists Find
45. Fennel Essential Oil and Extract, The Potent Anti Hypoglycemic Remedies, Scientists Reveal
46. Fennel, the Function Food Which Balances the Ratio of the Levels Free Radicals and Antioxidants in Our Body

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

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Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

The 33 Health Benefits of Carrot, Studies Suggested

By Kyle J. Norton

Carrot, a root vegetable with orange color is a subspecies of Daucus carota, belongings to the family Apiaceae, native to Asian and Europe.

Nutrients
1. Carbohydrates
2. Sugars
3. Fibre
4. Fat
5. Protein
6. Vitamin A
7. Thiamine (VittaminB1)
8. Riboflavin (Vittamin B2)
9. Niacin (Vittamin B3)
10. Vitamin B6
11. Folate (Vittamin B9)
12. Vitamin C
13. Vitamin K
14. Calcium
15. Iron
16. Magnesium
17. Molybdenum
18. Phosphorus
19. Potassium
20. Sodium
1. The Science of Root Vegetables: Carrot and its Bioactive Compounds in Prevention and Treatment of Breast cancer
2. Food therapy: Dietary Carrot In Attenuated Onset and Treatment of Prostate Cancer 
3. Food Therapy: Carrots In Attenuated Risk, Progression and Treatment of Lung Cancer 
4. Food Therapy: Wild Carrot, Single and Hidden Root Vegetable for Treatment of Skin Cancer, Endorsed By Online Published Medical Literature
5. Men’s Health: Protect Prostate Cells Viability Against Prostate Cancer with A Single Vegetable, Medical Literature Recommended
6. Food Therapy: Wild Carrot, Single and Hidden Root Vegetable for Treatment of Skin Cancer, Endorsed By Online Published Medical Literature
7. Food Therapy: Carrot. A Potent and Functional Vegetables in Ameliorated Risk and Treatment of Vulvar Cancer
8. Food Therapy: Carrots Prevent Leukemia
9. The carrot to Maintain A Healthy Skin, Naturally and Permanently, PubMed Studies Find 
10. The carrot to Prevent the Onset of Inflammatory Related Diseases Naturally, Medline Model Studies Show

11. Carrots EnhanceYour Immunity Naturally, US National Library of Medicine Studies Suggest
12. Carrots in Decreased Risk of Stroke, Naturally and Effectively, MEDLINE Studies Suggest
13. Carrots' carotenoids, the Secret Ingredients In Protection of Your Heart, Studies Provided by National Institutes of Health
14. Carrot, The Tasty Food That Gobbles Up Pathogenic Microorganisms, Scientists Revealed
15.  The Veggie and Plant That Suppress Oxidative Stress in Induction of Atherosclerosis, Cancers, Diabetes, Rheumatoid Arthritis, Post-ischemic Perfusion Injury, Myocardial Infarction, Cardiovascular Diseases,... and Stroke
16. The Root Vegetable That Prevents Macular Degeneration (AMD), Biomedical Literature Suggest
17. Carrot and Its Bioactive Chemical Compounds in Reduced Risk and Treatment of Colon Cancer
18. Carrot, The Functional Food Which Reduces Gastric/Stomach Cancer Risk By 26%
19. Carrot Stops Colon Cancer Cells From Spreading
20  How to Boost Your Bone Health
21. Carrot, the Potent Liver Protective Functional Food
22. Carrots, The Potent functional Food Which Protects the Brain Against Onset of Neuro-degenerative Disorders, Scientists Reveal
23. Carrots, The Veggie Which Normalizes Your High Blood Pressure With No Side Effects, Suggested By MEDLINE Studies
24. Carrot and its Bioactive Compounds In Reducing Risk, Progression and Treatment of Gastric Cancer
25, How to Protect Your Body From Heavy Metals and Chemical Toxicity, Effectively
26. Carrots, the Veggie Which Normalizes Levels of Blood Glucose in Patient with Hyperglycemia
27. Carrots, the Veggies with Anti Cancer Potential, Researchers Find
28. Carrot, The Vegetable Which Promotes Weight Loss and Prevents the Onset of Obesity
29. How to Have the Optimal Oral Health Naturally
30. Carrots, the Vegetable Which Protects Your Eyes Against Glaucoma, Scientists Find
31. Carrots Juice, The Potential Functional Drink in the Prevention and Treatment of Cardiovascular Disease
32.  Carrot Juice, the Potent Anti Hypertension Functional Food
33. Carrot, the Functional Food Which Normalizes the Levels of Cholesterol, Researchers Suggest

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Herbal Turmeric, the Natural Remedy for the Treatment of Rosacea, Human Study Find

By Kyle J. Norton

Rosacea is a chronic skin condition that affects the face, leading to redness, pimples, swelling, and dilated blood vessels.

The most affected areas are the nose, cheeks, forehead, and chin.

Epidemiologically, the condition may affect anyone, however, middle-aged women who have fair skin are more prone to the disease onset.

Most common symptoms of rosacea are facial redness, swollen red bumps, eye problem, and enlarged nose. If you have to experience the aforementioned symptoms, please check with your doctor to rule out the possibility.

As of today, there is no cure for the condition. Treatments are focused on controlling and reducing the signs and symptoms and improving quality of life, including

* Medications that reduce redness such as drug brimonidine (Mirvaso), particularly in patients with a mild case of rosacea.

* Oral antibiotics for the treatment of bacterial inflammation and infection

* In severe cases, Isotretinoin may be prescribed, if other therapies have failed to improve the condition.

Some researchers suggested that laser therapy may be the best approach to reduce the redness of enlarged blood vessels.

Dr. Daniel M. Keller wrote, "Oxyhemoglobin in the blood absorbs light from lasers at wavelengths of about 595 nm (pulsed dye laser) and 532 nm (KTP laser), creating heat that helps destroy capillaries that contribute to the appearance of rosacea. Over a period of 3-4 weeks, the vessels are resorbed, and facial redness diminishes".

And, "Laser therapy is also effective for background redness but will be less effective for people with the papules associated with rosacea and “almost not effective at all for preventing flushing".

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.

On finding a potential compound for the treatment of rosacea, researchers examined the effect of turmeric on facial redness, a multifactorial in nature and a sign of many different conditions, including rosacea, photodamage, and flushing.

The prospective, double-blind, randomized pilot study included 33 healthy participants recruited from the dermatology clinic at the University of California, Davis and nearby community from 2016 to 2017. 

Participants were randomized to receive one of three interventions (placebo, turmeric or polyherbal combination tablets) by mouth twice daily for 4 weeks.

By comparing the protection of turmeric and turmeric-containing polyherbal combination tablets versus placebo on facial redness, researchers found that facial redness intensity and distribution including rosacea showed a downtrend in the polyherbal combination group after 4 weeks.

Compared to the turmeric-containing polyherbal combination tablets treatment group, the placebo and turmeric groups had no statistically significant changes in image analysis-based facial redness.

In other words, turmeric-containing polyherbal combination tablets processed the ingredients that do not found in turmeric for the treatment of facial redness including rosacea.

Based on the findings researchers said, "Polyherbal combination tablet supplementation improved facial redness compared to the turmeric or placebo".

Taken altogether, turmeric combination with other herbal medicines may be considered supplements for the prevention and treatment of rosacea, pending to the confirmation of the larger sample size and multicenter human study.

Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Dietary supplementation with turmeric polyherbal formulation decreases facial redness: a randomized double-blind controlled pilot study by Vaughn AR1, Pourang A2, Clark AK2, Burney W2, Sivamani RK. (PubMed)
(2) Innovations in natural ingredients and their use in skin care by Fowler JF Jr1, Woolery-Lloyd H, Waldorf H, Saini R. (PubMed)
(3) Rosacea responds well to the laser, IPL therapies By Daniel M. Keller. ( MD Edge)

Bromelain, the Natural Promotion of Intestinal Health

By Kyle J. Norton

Intestinal health is a subject that covers multiple positive aspects of the gastrointestinal (GI) tract, including the effective digestion and absorption of food, promoting the balance of intestinal microbiota.

According to general knowledge, people who eat a diet with fruits and vegetables that are high in fiber have been found to process a healthy microbiota including beans and legumes and berries.

Believe it or not, the human gut microbiota contains trillions of cells, including bacteria, viruses, and fungi. The gut microbiota is important to improve the digestive function in the absorption of nutrition, before passing them to the cells and tissue in the body.

In the immunity perspective, the gut microbiota and immune system interact to protect each other to ensure the optimal function of both the digestive and immune system.

In other words, imbalanced gut microbiota not only causes the dysfunction of the digestive system but also reduces the functional immune system in the protection of the body against infection.

Furthermore, in the neuro-perspective, balanced gut microbiota also exerted a strong interaction between the microbiota and the enteric nervous system (ENS), leading to improvement of both systems against the risk of potential diseases that link the microbial dysbiosis to gastrointestinal disorders.

Dr. Sai Manasa Jandhyala, the lead scientist in the summary of the benefits of normal gut microbiota wrote, " The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug metabolism, maintenance of structural integrity of the gut mucosal barrier, immunomodulation, and protection against pathogens. 

And, Several factors play a role in shaping the normal gut microbiota. They include (1) the mode of delivery (vaginal or cesarean); (2) diet during infancy (breast milk or formula feeds) and adulthood (vegan based or meat based); and (3) use of antibiotics or antibiotic like molecules that are derived from the environment or the gut commensal community. A major concern of antibiotic use is the long-term alteration of the normal healthy gut microbiota and horizontal transfer of resistance genes that could result in a reservoir of organisms with a multidrug-resistant gene pool.

Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and for the treatment of pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.

With an aim to find a natural ingredient for the improvement of intestinal health researchers examined the effect of bromelain found in the pineapple on leukocyte migration, activation, and production of cytokines and inflammatory mediators in vitro.

According to the enzyme immunoassays, injection of bromelain induced immune response, However, in the digestive process, bromelain sensitive molecules formulated in antacid from both leukocytes and colon epithelial cells were removed, leading to retaining substantial proteolytic activity.

Where proteolysis is the process of breaking down of proteins into smaller polypeptides or amino acids which play an integral role in removing toxins from the body, supports metabolism, encourage healthy digestion.

 Dr. Hale LP, the lead scientist said, "Although anti-bromelain IgG was detected in both serum and stool after long-term oral therapy, these antibodies did not prevent bromelain proteolytic activity within the gastrointestinal tract".

Based on the findings, researchers suggested bromelain enzymes that remain intact after oral administration proteolytically protect the murine gastrointestinal tract by modifying the colonic inflammation.

In order to reveal more information about bromelain used in some developed countries for the protection of colonic inflammation, researchers examined the bromelain, a crude extract from the pineapple stem on digestive health.

In an animal model, oral administration of bromelain improves the decrease in defecation in abdominal postoperative rats.

Furthermore, injection of bromelain inhibited overexpressed the mRNA protein associated with the initiation of inflammation and restored the protein mRNA involved the production of anti-inflammatory cytokines in the colon of the postoperative rats.

Dr. Wen S, the lead scientist said, "(The result strongly suggested that) bromelain improves decrease in defecation in postoperative rats, at least in part, by inhibiting colonic iNOS overexpression via the NF-kappaB pathway".

Taken altogether, bromelain may be considered supplements for the promotion of intestinal health, pending to the confirmation of the larger sample size and multicenter human study.

Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Proteolytic activity and immunogenicity of oral bromelain within the gastrointestinal tract of mice by Hale LP. (PubMed)
(2) Bromelain improves decrease in defecation in postoperative rats: modulation of colonic gene expression of inducible nitric oxide synthase by Wen S1, Huang TH, Li GQ, Yamahara J, Roufogalis BD, Li Y. (PubMed)
(3) Role of the normal gut microbiota by Sai Manasa Jandhyala, Rupjyoti Talukdar, Chivkula Subramanyam, Harish Vuyyuru, Mitnala Sasikala, and D Nageshwar Reddy. (PMC)

3,3'-Diindolylmethane for the Prevention and Treatment of Renal Fibrosis

By Kyle J. Norton


Renal fibrosis is a condition of kidney scars caused by improper healing of the kidney in regenerating damaged cells after an injury.

The process of kidney healing after injury involved serval overlapping phases, including inflammation, extracellular matrix (ECM) synthesis,  production and dissolving collagens,  regeneration, and remodeling.

Renal fibrosis over time may result in progressive loss of kidney function, leading to kidney failure in the advanced stage. 

Epidemiological studies suggested that age, gender, genetics, and perpetual activation of fibroblasts through priming are some of the prevalent factors that cause on the set of poor healing of kidney in the initiation of renal fibrosis.

Most patients with renal fibrosis are asymptomatic. Therefore, most cases of renal fibrosis are diagnosed at the advanced stage.

At this stage, patients may experience symptoms of chronic kidney disease (CKD), including weight loss and poor appetite. swollen ankles, feet or hands due to water retention, and blood in your urine. 

As of today, there are no effective treatments for preventing the progression of renal fibrosis. Treatments of renal fibrosis are to reduce symptoms and delay the disease progression of the disease.

3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.


On finding a natural compound for the treatment of renal fibrosis with no side effects, researchers in the renal disease team led by the Renmin Hospital of Wuhan University examined 3,3'-Diindolylmethane (DIM), a natural acid condensation extracted from cruciferous plants, anti-fibrotic effects.

Selected rat kidney (NRK)-49F fibroblast cell mouse models induced renal fibrosis by a unilateral ureteral obstruction (UUO) and stimulated the production of transforming growth factor (TGF)-β1.

Where transforming growth factor (TGF)-β1 are inflammatory cytokines that frequently occur together during a regulatory T cell response.

According to the tested assays, treatment of DIM reduced kidney injury and production of interstitial collagens fibrosis.

Furthermore, DIM inhibited the expression of fibronectin involved in cell adhesion, growth, migration, and differentiation and increased fibronectin were found to associate with hypertrophic scars. and collagen-1 the collagen fiber involved the formation of scars.

Moreover, DIM promotes the expression of a protein associated with tumor suppression E-cadherin in the UUO model that protects the healing against the formation of scars.

DIM suppressed local fibroblast proliferation, a process that begins with a reaction to the clot associated with scar developing, observed by the scar contraction with the level of α-smooth muscle actin (α-SMA) and vimentin in scar tissue.

Additionally, DIM inhibited the renal fibrosis by significantly reduced the TGF-β1-induced proliferation of NRK49F cells in a time- and dose-dependent manner.

Interestingly, DIM decreased Smad2/3 phosphorylation associated with the excessive deposition of collagen and but increased Smad7 expression against keloid formation.

The results strongly suggested DIM inhibited the transforming growth factor (TGF)-β1 in the activation of proteins and genes associated with the formation of scarrings.

Dr. Xia ZE, the lead scientist said, " DIM inhibits TGF-β/Smad2/3 signaling to attenuate renal interstitial fibrosis via inhibiting local fibroblast activation".

Taken altogether, DIM may be considered a supplement for the prevention and treatment of renal fibrosis through its anti- renal scarring activity, pending to the confirmation fo larger sample size and multicenter human study.

Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of renal fibrosis,, pending to the confirmation of the larger sample size and multicenter human study.

Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight

How To Get Rid Of Eye Floaters 
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally 

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca


Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) 3,3'-Diindolylmethane ameliorates renal fibrosis through the inhibition of renalfibroblast activation in vivo and in vitro by Xia ZE1, Xi JL2, Shi L. (PubMed)

Herbal Bilberry Anthocyanin, the Easy Way to Protect the corneal epithelium Against UV-induced Photokeratitis

By Kyle J. Norton


Photokeratitis is an uncommon condition induced eye pain caused by exposure to the ultraviolet (UV) rays from either the sun or artificial sources.

Under normal condition, the automatic pupil dilation protects the eyes by reducing the energy entering the eye. In some cases, if the levels of visible light are very high, the instinct reflex of the bain take over to have the eye either close or turn away from the energy sources.

Snow blindness caused by the reflection of UV rays is very common in people who live in the areas of the North and South Pole and high mountains.

Most common symptoms of photokeratitis, depending on the time-length exposure include pain, redness, blurriness, swelling,  headache, and temporary vision loss.

Some patients may experience also temporary color changes in your vision.or vision loss.

You can easily protect your eyes against photokeratitis by wearing sunglass in the bright day,  reduced time exposure to artificial UV.

Normally, the condition goes away on its own within a few days. Treatment is totally depending on the severity of the symptoms, ranging from flushing with warm water, prescribed eye drops or antibiotics in case of infection.

Researchers in the urgency to find the ingredient for the treatment of acute UVB exposure induced photokeratitis and apoptosis in corneal cells compared the effects of either nano-AST, AST oil, lutein, or bilberry extract 3 hours before and shortly before UV irradiation (dose: 400 mJ/cm2) in mice.

24 hours after irradiation, according to the sample collected, corneal epithelium was significantly thicker in mice orally administered with nano-AST than in the others (p < 0.01), with significantly less NF-κB nucleus translocation involved in the induction of proinflammation, and significantly fewer TUNEL cells associated with apoptotic DNA fragmentation.

Weaker dihydroethidium (DHE) associated with free radical oxidation was detected in the nano-AST group (p < 0.05) relative to the others.

In other words, nano-AST protects the corneal tissues and cells by reducing inflammation and decreasing cell death.

Dr. Harada F, the lead researcher said, "Oral administration of nano-AST demonstrated a protective effect on UV-induced photokeratitis via antioxidative, anti-inflammatory, and antiapoptotic activity".,

Additionally, in order to obtain more information of researchers examined administered with AST diluted in polyethylene glycol (PEG) in instillation form (15 μl) to the right eye in C57BL/6 mice against UV-photokeratitis.

Before injecting with AST, UVB exposure mice induced cell death and thinning of the corneal epithelium. However, the epithelium was restored after irradiation in AST-treated corneas.

Compared to those treated with vehicle, irradiated corneal epithelium was significantly thicker in eyes treated with AST eye drops and less cell apoptosis.

Furthermore, AST also reduced oxidative stress in irradiated corneas.

In other words, AST-treated cultures after UVB-irradiation protects the corneal tissue and cells against the cytotoxicity of TKE2 cells.

Based on the finding, Dr. Lennikov A and colleagues wrote, "Topical AST administration may be a candidate treatment to limit the damages by UV irradiation with wide clinical applications".

Taken altogether, anthocyanin, a carotenoid, presented in seafood, may be considered a functioning remedy for the treatment of photokeratitis, pending to the validation of larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

References
(1) Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice by Harada F1,2, Morikawa T1, Lennikov A3,4, Mukwaya A3, Schaupper M3, Uehara O5, Takai R6, Yoshida K1, Sato J1, Horie Y7, Sakaguchi H8, Wu CZ2,9,10, Abiko Y1, Lagali N3, Kitaichi N. (PubMed)
(2) Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops by Lennikov A1, Kitaichi N, Fukase R, Murata M, Noda K, Ando R, Ohguchi T, Kawakita T, Ohno S, Ishida S. (PubMed)