Wednesday, 10 June 2020

Omega-3 Fatty Acids May Be Used for the Treatment of Acids Sickle Cell Anemia

By Kyle J. Norton


Anemia is a condition of deficiency of hemoglobin, leading to not enough red blood cells in the body. The function of hemoglobin is to carry oxygen from the lung to the body' s cells.

Depletion of the stored iron can cause reduced hemoglobin production, leading to iron deficiency anemia.

Iron deficiency is simply as too little iron in the body for the production of hemoglobin.

A long-term deficiency of folate and vitamin B-12 plays a critical role in the production of healthy red blood cells associated with an increased risk of Amenia.

Also, people with the mutated gene inherited from the parent are at substantial risk of the disease. The Duliajan College study suggested that certain genes have been found to induce anemia.

Anemia occurs when there isn't enough hemoglobin to transport oxygen to the body cells and organs need, leading to symptoms of irritability, fatigue, shortness of breath, low blood pressure, etc.
Approximately, 2 out of 1000 people in Canada are considered an iron deficiency.

Sickle cell anemia (SCD), a genetic preposition form of anemia is a condition associated with not enough healthy red blood cells to carry adequate oxygen throughout your body.

The red blood cells in sickle cell anemia patines are rigid and sticky with the shapes of sickles or crescent moons.

The normal red blood cells live for about 120 days compared to the sickle cells that die in 10 to 20 days. In other words, the inability of the body to replace the cell that dies rapidly with new blood cells is a cause of sickle cell anemia.

According to the statistics, provided by the CDC, approximately 100,000 Americans are living with SCD. Ethnically, 1 out of every 365 Black or African-American births, 1 out of every 16,300 Hispanic-American births and 1 in 13 Black or African-American birth are sickle cell trait (SCT) carriers.

Conventionally, except for bone marrow transplant, treatments of sickle cell anemia are to improve quality of life, by relieving symptoms and preventing complications.


Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of anemia, researchers examined the Lipoxygenase products of the omega-3 fatty acids (O3FAs), docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids, on anti-inflammatory pain and episodes of vaso-occlusion in sickle cell anemia (SCD).

According to the results of the study included children with SCD HbSS-disease (n = 38) and age/race-matched HbAA-controls (n = 18),\
* The anti-inflammatory DHA and EPA (FA-Ratio) were increased in both phosphatidylcholine and phosphatidylethanolamine in HbSS compared to controls.

* Correlations were noted in HbSS subjects between hs-CRP and FA-Ratios (p = 0.011).

* FA-Ratios increased with age (p = 0.0007) due to an increase in pro-inflammatory AA with a concomitant decrease in anti-inflammatory DHA.

Based on the evidence, researchers said, "Findings demonstrate relative deficiencies in HbSS of the anti-inflammatory precursor fatty acids DHA and EPA, which correlates positively with hs-CRP".


Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the treatment of sickle cell anemia, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Relationship of Omega-3 fatty acids DHA and EPA with the inflammatory biomarker hs-CRP in children with sickle cell anemia by Setty BNY1, Betal SG2, Miller RE3, Brown DS3, Meier M4, Cahill M4, Lerner NB4, Apollonsky N4, Stuart MJ. (PubMed)

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