Herbal Angelica Protects Diabetics Against Renal Damage

By Kyle J. Norton

Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream to regulate the glucose.

In other words, diabetes occurs when cells in the pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases, diabetes is also caused by allergic reactions of cells in the immune system.

There are 2 major types of diabetes

Most common types of diabetes are
* Type 1 diabetes, also known as juvenile diabetes or insulin-dependent diabetes, the most common form diabetes found in children is a condition in which the pancreas does not produce any insulin. The most common form of type 1 diabetes is caused by genetic mutation and some viruses.

* Type 2 diabetes is a medical condition characterized by insufficient insulin entering the bloodstream to regulate the glucose due to either cell in pancreas dying off or receptor sites clogged up by fat and cholesterol.

The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.

The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.

Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.

Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.

In other words, kidney disease often has no symptoms until at a very advanced stage.

Diabetic kidney damage is a type of kidney injury caused by diabetes.

Kidney damage caused by diabetes usually occurs slowly, over many years. The injury can also lead to other health problems, including high blood pressure and glomerulonephritis,, an inflammation of the kidney's filtering units.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

On finding a natural compound for the treatment of kidney diseases, the researchers examined the effects of an arabinoglucan (AG) isolated from Angelica Sinensis on diabetic nephropathy (DN) induced in rats by streptozotocin.

The rats intraperitoneally treated with AG for 8 weeks induced Diabetes exhibited renal dysfunction, as evidenced by reduced creatinine clearance, increased blood urea nitrogen and proteinuria, along with the marked enhanced mesangial expansion.

Overproliferation of glomerular mesangial cells (GMCs) that remove trapped residues and aggregated protein halted by AG treatment

Furthermore, AG treatment rats also inhibited the and inflammation mediators associated with inflammatory cytokines.

Moreover, AG also significantly inhibited the expression of nuclear factor-κB (NF-κB) against inflammation and receptor for advanced glycation end products (RAGE) induced oxidative stress by interacting and binding to RAGE,  both in diabetic kidneys and in high glucose-induced GMCs.

Based on the findings, researchers said, " AG, acting as a RAGE antagonist, is a promising agent for the prevention and treatment of DN".

Taken altogether, Herbal Angelica may protect the diabetics kidney against DN, pending to larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) A branched arabinoglucan from Angelica sinensis ameliorates diabetic renal damage in rats by Sui Y1, Liu W1,2, Tian W3, Li XQ3,4, Cao W. (PubMed)