Common Fig or Fig (Ficus carica) Gobbles Up Glioblastoma GBM Cells in Vitro

By Kyle J. Norton



The brain and spinal cord made up the nervous system. Brain and Spinal Cord tumors originating are not very common. Most primary tumors are caused by abnormal cell growth that surrounds and supports neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous.

More than 190.000 people in the US are diagnosed with a brain tumor each year alone.

Brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue.

Glioblastoma or glioblastoma (also called GBM) caused mostly by the abnormal astrocytic cells and dead cells (necrosis) is considered one of the most aggressive cancers induced by the alternation of cells originated from the brain, including the cerebral hemispheres.

Most patients with GBM experience symptoms of brain swelling caused by the overexpression of the fluid surrounding the tumor.

Conventionally, due to the nature of rapid growth, surgery is necessary to relieve the brain pressure and remove the tumor as much as possible, followed by radiation and chemotherapy.

According to the statistics, in the US, the incidence affects mostly in the elderly with the diagnosed rate of 3.19 per 100,000 persons. The disease is rare in children.

GBM is deadly, patients with GBM have a median survival of less than one year and less than 2% of patients survive three years or more.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches.

On finding natural compounds for the treatment of neurological diseases, researchers examined the cancer suppressive effect of Ficus carica (fig) latex (FCL) on glioblastoma (GBM).

On T98G, U-138 MG, and U-87 MG GBM cell lines treated by the combination of FCL and  FCL-temozolomide (TMZ), according to the tested differentiation,

* FCL causes cell death in GBM cells with different responses to FCL-temozolomide (TMZ), an oral chemotherapy drug.

* The cell death was attributed synergistically increased in combination with TMZ

* More importantly, the effect of FCL on the modulation of let-7d expression by suppressing proliferation and cell migration may be an important underlying mechanism of the anti-invasive effect of this extract.

Taken altogether, common fig or fig (Ficus carica)  used in a combination with chemo drug may be considered a remedy for the treatment of glioblastoma (GBM), pending to the confirmation of the larger sample size and multicenter human study.



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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Ficus carica latex prevents invasion through induction of let-7d expression in GBM cell lines by Tezcan G1, Tunca B, Bekar A, Yalcin M, Sahin S, Budak F, Cecener G, Egeli U, Demir C, Guvenc G, Yilmaz G, Erkan LG, Malyer H, Taskapilioglu MO, Evrensel T, Bilir A. (PubMed)