Thursday 25 June 2020

Herbal Angelica Protects The Stomach Cells Against the Onset of Gastric Cancer

By Kyle J. Norton

The stomach located between the esophagus and the small intestine is a muscular, hollow and important organ of the digestive tract. The pyloric sphincter is a muscular valve that opens to allow food to pass from the stomach to the small intestine.

The stomach secretes acid and enzymes to digest food.  The stomach muscles contract periodically, churning food to aid digestion.

Gastric/Stomach cancer is a chronic condition characterized by irregular cell growth in the tissues of the stomach. Adenocarcinoma is the most common type of gastric cancer.

Most people with primary cancer have an increased risk of secondary cancers of the thyroid and small intestine.

More precisely, common site metastasises from primary gastric cancer is the secondary liver (48%), peritoneum (32%), lung (15%), and bone (12%).

Most cases of gastric cancer start in the cells on the surface of the inner lining of stomach tissue.
Due to the small size at the early stage, gastric cancer is asymptomatic.

However, at the later stage, after penetrating into the deeper layers of the stomach, the cancer cell may travel a distance away to infect other healthy tissues and organs, leading to secondary metastasis.

At this stage, most patients with gastric cancer may experience symptoms of severe abdominal pain caused by the suppressing of the oversize tumor on the nerve cells, or vague discomfort in the abdomen, usually above the navel, particularly heartburn and indigestion, accompanied by general symptoms shared with other types of cancer.

According to the statistics provided by the American Cancer Society, in 2019, approximately, 27,510 cases of stomach cancer will be diagnosed (17,230 in men and 10,280 in women) and 11,140 people will die from gastric cancer (6,800 men and 4,340 women).

Overall, the 5-year survival rate for people with gastric cancer is 31%. Cancer diagnosed at the localized stage have a 5 years survival rate of 67%.

In Canada, Gastric cancer affects 2.1% of male cancer patients and 1.3% of female cancer patients.

The most common causative risk factor of gastric cancer is infection with a common bacteria, H. pylori, which were found to cause ulcers and Inflammatory gastritis,.


On finding a natural ingredient for the prevention and treatment of digestive diseases, scientists examined the effects of danggui (Chinese angelica) isolated compound N-butylidenephthalide (BP) on gastric cancer.

Angelica or danggui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to results that angelica used for the treatment in patients with gastric cancer, using data from Taiwan's National Health Insurance Research Database (NHIRD),
* Danggui users showed an increased survival rate, compared with non-danggui users.

* Treatment of danggui are highly associated with decreased mortality.

* Furthermore, in vitro results BP inhibited gastric cancer cell proliferation, and induced cellular apoptosis depending on the activation of the mitochondrial apoptotic pathway.

* Moreover, BP caused an increase of REDD1 expression associated with the regulation of cell damage that inhibits mTOR signaling involved in tumor formation and angiogenesis.

Additionally, BP also suppressed the growth of AGS xenografts tumor in vivo.

Based on the results, researchers suggest, "Danggui can prolong the survival rate of gastric cancer patients in Taiwan. BPDD1 expression leading to mTOR signal pathway inhibition in gastric cancer cells. BP inhibited the in vivo growth of AGS xenograft tumors".

Taken altogether, Danggui processed abundantly bioactive compound N-butylidenephthalide (BP)  may be considered an herbal medicine for the treatment of gastric cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Cancer Effects of Radix Angelica Sinensis (Danggui) and N-Butylidenephthalide on Gastric Cancer: Implications for REDD1 Activation and mTOR Inhibition by Liao KF1,2, Chiu TL3,4, Huang SY5, Hsieh TF3,6, Chang SF7, Ruan JW8, Chen SP9, Pang CY10,11, Chiu SC. (PubMed)

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