Reactive oxygen species (ROS) or free radicals are highly reactive chemical species containing oxygen molecules. In other words, free radicals are unstable atoms with an unpaired electron in the outer ring.
Therefore, in order to become stable, free radicals must either donate or steal an electron from other atoms, leading to a chain reaction that can not be stopped until all electrons are paired or inhibited by antioxidants.
Believe it or not, free radicals in moderate amounts are needed for our body for cell signaling and activation of several transcriptional factors, apoptosis, immunity, and differentiation. However, overexpression of free radicles can cause damage to protein, lipid, and cell alternation, leading a number of chronic illnesses, including cancer.
Free radicals are generated as metabolic by-products by biological systems. Environmental stressors (i.e., the air we breathe, UV, ionizing radiations, pollutants, and heavy metals) and xenochemicals are also found to contribute to the great increase of ROS production.
In a healthy individual, the production of free radicals is balanced by the antioxidant enzymes produced by the body.
Antioxidants are stable atom that plays a critical role in protecting the body against the attack of free radicals.
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid, and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
In other words, antioxidants inhibited the onset of free radical before they can cause a chain reaction in facilitating the protein, lipid, and cell damage.
Antioxidants can either produced by the liver or intake from dietary sources. Under normal conditions, antioxidant enzymes produced by the body in a healthy individual are good enough to counter the bombardment of free radical attacks.
Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.
The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
On finding a potential phytochemical for the treatment of diseases associated with oxidative stress, researchers examined the intake of EPA:DHA 6:1 (500 mg/kg/day) for 2 weeks on endothelial dysfunction in old rats (20 months old).
On finding a potential phytochemical for the treatment of diseases associated with oxidative stress, researchers examined the intake of EPA:DHA 6:1 (500 mg/kg/day) for 2 weeks on endothelial dysfunction in old rats (20 months old).
According to the results of the analysis,
Before application with DHA
* Endothelial dysfunction characterized by a blunted NO component, an abolished endothelium-dependent hyperpolarization component, and increased endothelium-dependent contractile responses (EDCFs) are observed in old rats compared to young rats.
* Furthermore, age-related endothelial dysfunction was found to increase the vascular formation of reactive oxygen species (ROS) and expression of eNOS.
After treatment with DHA
* The EPA:DHA 6:1 treatment improved the NO-mediated relaxation, reduced the EDCF-dependent contractile response and the vascular formation of ROS, and normalized the expression level of all target proteins in the old arterial wall.
Collectively, researchers said, "a 2-week intake of EPA:DHA 6:1 by old rats restored endothelium-dependent NO-mediated relaxations, most likely, by preventing the upregulation of the local angiotensin system and the subsequent formation of ROS".
Taken altogether, Omega-3 fatty acids found abundantly in fish oil and plant oil may be considered a functional food for the prevention of diseases associated with ROS, pending to the confirmation of the larger sample size and multicenter human study.
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery by Farooq MA1, Gaertner S2, Amoura L1, Niazi ZR1, Park SH1, Qureshi AW1, Oak MH1, Toti F1, Schini-Kerth VB3, Auger C. (PubMed)
Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Intake of omega-3 formulation EPA:DHA 6:1 by old rats for 2 weeks improved endothelium-dependent relaxations and normalized the expression level of ACE/AT1R/NADPH oxidase and the formation of ROS in the mesenteric artery by Farooq MA1, Gaertner S2, Amoura L1, Niazi ZR1, Park SH1, Qureshi AW1, Oak MH1, Toti F1, Schini-Kerth VB3, Auger C. (PubMed)
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