Saturday 13 June 2020

Herbal Angelica Suppresses the Growth of Malignant Brain Tumors in Vitro and Vivo

By Kyle J. Norton

The central nervous system is a part of the nervous system of the brain and spinal cord with the function of integrates information it receives from for the entire nervous system, and control all the workings of your body.

The central nervous system (CNS) controls most functions of the body and mind, consisting of two parts: the brain and the spinal cord.

In other words, the brain plays a critical role in the central nervous system associated with our thoughts, the interpreter of our external environment, and the origin of control over body movement

Brain and Spinal Cord tumors originated are not very common.

Brain cancer is a medical and chronic condition characterized by cell growth disorderly in the brain tissue.

Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in the US are diagnosed with a brain tumor each year alone.

Most brain types of brain cancer in the older adult ages 50 to 60 are Chordomas. The cancer is a rare and slow-growing, but it can invade adjacent bone and put pressure on the nearby neural tissue.

Meningiomas, the most common type of benign brain tumor of the age group 40-50s. However, a small percentage of these tumors can be malignant.

According to the statistic provided by the Canadian cancer society, Every day about 25 Canadians is diagnosed with a brain tumor.

The 5-year survival rate of brain cancer is only 25%, compared to over 60% for cancers overall. Most adults with a diagnosis of aggressive glioblastoma survive only 1–2 years after their diagnosis.

Some researchers suggested genetic preposition and acquired gene mutation due to long-term exposure to chemical toxins may be the prevalent risk factor that causes the alternation of brain cell DNA.

Most common symptoms of brain cancer depending on the stage are persistent headaches and localized pain, gradual loss of sensation and movement, speech difficulty and persistent pain



On finding a natural ingredient for the prevention and treatment of neuro- diseases, scientists examined the methanol extract of Angelica sinensis (AS-M) effects on malignant brain tumors.

Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.

The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.

According to the results of the tested analysis,
* AS-M also displays potency in suppressing the growth of malignant brain tumor cells.

* AS-M suppressed the growth suppression of malignant brain tumor cells by AS-M through cell cycle arrest and apoptosis.

More precisely, AS-M upregulates the expression of cyclin kinase inhibitors involved in prohibiting progression from the G1 phase to the S phase in tested cancer cells.

* AS-M also exhibited the tumor suppressor expression of the p53 protein to induce apoptosis.

Collectively, in vivo studies, AS-M not only suppressed the growth of human malignant brain tumors but also significantly prolonged patient survival, involving cell cycle arrest, apoptosis, and antiangiogenesis.

Based on the results, researchers suggest, " The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new anti-brain tumor agent, providing new hope for the chemotherapy of malignant brain cancer".

Taken altogether, Dandelion may be considered a remedy for the treatment of brain cancer, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors by Lin YL1, Lai WL, Harn HJ, Hung PH, Hsieh MC, Chang KF, Huang XF, Liao KW, Lee MS, Tsai NM. (PubMed)

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