Thursday 4 June 2020

Common Fig or Fig (Ficus carica), the Anti-inflammatory Healthy Food

By Kyle J. Norton

Inflammation is a natural defense that protects our body against the invasion of foreign stimuli, including damaged cells, irritants, pathogens.

In the body tissue damage caused by physical impact or other sources, macrophages, the immune first line of defense, stimulate the production of proinflammatory cytokines to the site with an aim to protect our body by destroying possible bacteria or virus invasion.

However, in most cases, a prolonged period of overproduction of inflammatory cytokines can cause damage and death of the healthy cells, leading to tissue damage and the formation of abnormal scars after healing.

Inflammation can be acute or chronic
*Acute inflammation is a result of the immune white blood cell response to tissue damage or injury by stimulating the production of proinflammatory cytokines to kill off the microorganism which tries to enter the body through the wound.

*Chronic inflammation is inflammation that lasts more than 3 months, occurred when the immune system response cannot destroy all pathogens in the acute phase of infection.

Chronic inflammation also can be caused by an autoimmune disorder in which the immune white blood cells mistakenly attack the body's localized tissue, such as cancers and rheumatoid arthritis.

Symptoms associated with acute inflammation are depending on the location of the inflammation. including pain, swelling, redness, and heat.

Over time, chronic inflammation can have a strongly negative impact on the affected tissues and organs.

The causes of chronic inflammation also include autoimmune disorders, in which the immune system mistakenly attacking healthy tissue and long-term exposure to irritants, such as industrial chemicals or polluted air.

Fig is a species of F. Carica, belonging to the family Moraceae. It is a deciduous shrub, native to Southeast Asia. The tree can grow to a height of 33 ft and the fruit can be as large as 2.0 inches


On finding a natural whole food or compound for the treatment of inflammatory diseases, scientists investigated the anti-inflammatory activity of chemical constituents of the fruits of F. Carica.

According to the chemical analysis, 4 new structurally diverse prenylated isoflavone derivatives, ficucaricones A-D (1-4), along with 12 known analogs (5-16) were separated from the fruits of F. Carica.
The antioxidant assay revealed that the renylated isoflavone derivatives (1-16) displayed remarkable inhibitory effects against nitric oxide (NO) production with the IC50 values ranging from 0.89 ± 0.05 to 8.49 ± 0.18 μM, compared to a positive control (hydrocortisone).

Furthermore, through its anti-oxidative stress activity, the compounds 1-16 also exhibited pronounced antiproliferative activities against diverse human cancer cell lines in vitro, holding the IC50 values ranging from 0.18 ± 0.03 to 18.76 ± 0.09 μM.

Based on the findings, researchers said, "These findings indicate that regular consumption of the fruits of F. Carica may help to prevent the occurrence of inflammatory diseases and tumors".

 Taken altogether, Common Fig or Fig (Ficus carica)  processed abundantly anti-inflammatory and tumor antioxidants may be considered a remedy for the prevention and treatment of chronic inflammatory diseases, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Anti-Inflammatory and Antiproliferative Prenylated Isoflavone Derivatives from the Fruits of Ficus carica by Liu YP1,2,3, Guo JM1,3, Yan G1,3, Zhang MM1,3, Zhang WH1,3, Qiang L2, Fu YH. (PubMed)

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