Tuesday 16 June 2020

Japanese Angelica Exerts a Strong Neuro-Protective Activity

By Kyle J. Norton

Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.

In other words, neuroprotection protects the neuronal integrity against the rate of neuronal loss over time, inducing neurological disease, including neurodegenerative disease.

Brain ischemia is a condition caused by insufficient blood flow to the brain to meet metabolic demand, leading to irreversible brain damage in severe cases.

In other words, brain ischemia-induced the death of neurons of the affected tissues.

A neuron or nerve cell made of a cell body (also called soma), dendrites and an axon, is a cell in the nervous system that carries electrical impulses.

Neurons are core components of the brain, spinal cord and peripheral nerves that play an essential role to process and transmit information.

The function of neurons can be classified into 3 types
* The sensory neurons found within the nervous system that convert external stimuli from the organism's environment into internal electrical impulses. In other words, sensory neurons are activated by sensory input from the environment, including physical input of sound, touch, heat, or light.

*The motor neurons transmit impulses from the spinal cord to skeletal and smooth muscles,. In other words, motor neurons directly control all of the muscle movements.

* The interneurons connect the motor and sensory neurons. In other words, the interneurons transfer signals between sensory and motor neurons.

Angelica shikokiana (Apiaceae) is a Japanese traditional herb that is widely marketed as a dietary food supplement as a health tea preparation consumed as a daily beverage for health benefits.

On finding a potential phytochemical for the prevention and treatment of neurological diseases researchers examined the neuroprotective activities of compounds from Angelica shikokiana Makino.

According to the chemical analysis, 
* Quercetin showed a strong neuroprotective effect the strongest AChE (IC50 value = 35.5 µM) through binding to active-site peptides and activation of Tyr-70 residues at the catalytic and anionic sites of acetylcholine esterase, respectively.

* Furthermore, chemical compounds chlorogenic acid, angelica methyl ester, quercetin, and luteolin demonstrated a significantly protect neuro-2A cells against free radical H2O2-induced neurotoxicity by the scavenge hydroxyl radical and intracellular reactive oxygen species.

* Moreover, Kaempferol-3-O-rutinoiside, hyuganin E and isoepoxypteryxin found in the herbal medicine also significantly decreased Aβ25-35-induced neurotoxicity and Th-T fluorescence.

Taken altogether, Angelica shikokiana Makino processed abundantly bioactive compounds may be considered a supplement for neuroprotection, pending to the confirmation of the larger sample size and multicenter human study.

Intake of beta-Sitosterol in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) In vitro neuroprotective activities of compounds from Angelica shikokiana Makino by Mira A1,2, Yamashita S3, Katakura Y4, Shimizu K. (PubMed)

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