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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.
1. Saturated fat and Trans fat(145)
Saturated fat is important for energy, hormone production, cellular membranes, especially in signalling and stabilization processes in the body, but over consumption can cause cholesterol building up in the arteries leading to heart diseases, stroke, diabetes, etc. A high saturated fat and cholesterol intake has shown to increase the risk of dementia, whereas fish consumption may decrease this risk(135)(145), probably due to involvement in the β-oxidation process of long-chain fatty acids, very-long-chain fatty acids, and branched-chain fatty acids of peroxisome(133)(145) in the breaks down molecules into smaller units to release energy of very long chain fatty acids(134). Intake of trans fat is also found to potentially increase the AD risk or cause an earlier onset of the disease due to its effects in increased production of amyloid beta (Aβ) peptides, main components of senile plaques(136).
2. Artificial sweetener
Artificial sweetener can cause obesity risk of dementia independent of diabetes and cardiovascular comorbidities(137). and induced increasing consumption of fat(138).
3. Fast Foods
Fast foods, unwholesome foods, containing high amounts of artificial ingredients, with an aim to be cooked fast and handed over to the customer in minutes may induce anxiety, tension, depression, difficulty in concentration, and memory of that can lead to onset of senile dementia(139).
4. Artificial ingredients
A standard American diet containing high amount of MSG and aspartame may induce the early onset of neurodegenerative disease(140)
Moderate alcohol drinking is associated with a reduced risk of unspecified incident dementia and AD(141)(145), but excessive consumption of alcohol not only causes liver damage but also increases risk of neuro-degeneration, including onset of dementia due to its neurotoxic and neuroprotective effect(142).
6. Low intake of fruits and Vegetables
Nutrition plays a role in the ageing process of the brain and suboptimal nutrient. According to The Chinese University of Hong Kong, older people with questionable dementia have lower intakes of vegetables, fruits(145) and fluid than those who were cognitively normal(143)
The typical American diet containing high amounts of red meat has shown to increase risk of cholesterol building up in the blood vessels and capillaries in causation of heart diseases and stroke(144) and cognitive impairment(135).
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(135) Dietary fat intake and the risk of incident dementia in the Rotterdam Study by Kalmijn S1, Launer LJ, Ott A, Witteman JC, Hofman A, Breteler MM.(PubMed)
(136) Trans fatty acids enhance amyloidogenic processing of the Alzheimer amyloid precursor protein (APP) by Grimm MO1, Rothhaar TL, Grösgen S, Burg VK, Hundsdörfer B, Haupenthal VJ, Friess P, Kins S, Grimm HS, Hartmann T.(PubMed)
(137) Can artificial sweeteners help control body weight and prevent obesity? by Benton D1.(PubMed)
(138) Central obesity and increased risk of dementia more than three decades laterby R. A. Whitmer, PhD, D. R. Gustafson, PhD, E. Barrett-Connor, MD, M. N. Haan, DrPH, E. P. Gunderson, PhD and K. Yaffe, MD(Neurology)
(139) Evaluation of diet and life style in etiopathogenesis of senile dementia: A survey study. by Chaudhuri K1, Samarakoon SM, Chandola HM, Kumar R, Ravishankar B.(PubMed)
(140) WHERE CTE, DIET, and NEURODEGENERATION MEET(Reversing disease for optimal health)
(141) Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes by
Panza F1, Capurso C, D'Introno A, Colacicco AM, Frisardi V, Lorusso M, Santamato A, Seripa D, Pilotto A, Scafato E, Vendemiale G, Capurso A, Solfrizzi V.(PubMed)
(142) Alcohol and cognition in the elderly: a review by Kim JW1, Lee DY, Lee BC, Jung MH, Kim H, Choi YS, Choi IG.(PubMed)
(143) Lower fluid and fruits/vegetable intake in questionable dementia among older Hong Kong Chinese.by Lee J1, Lam L, Woo J, Kwok T.(PubMed)
(144) Meat consumption in relation to mortality from cardiovascular disease among Japanese men and women by Nagao M1, Iso H, Yamagishi K, Date C, Tamakoshi A.(PubMed)
(145) Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective? by Panza F1, Frisardi V, Seripa D, Logroscino G, Santamato A, Imbimbo BP, Scafato E, Pilotto A, Solfrizzi V.(PubMed)