Monday, 19 December 2016

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant Metals binding proteins Ceruloplasmin

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.

      The Antioxidant Metals binding proteins Ceruloplasmin

The expression of metal-binding proteins or peptides in microorganisms and plants in order to enhance heavy metal accumulation and/or tolerance has great potential, according to Dr. Malin Mejárea, Leif Bülow in the study of Metal-binding proteins and peptides in bioremediation and phytoremediation of heavy metals, leading to reduced oxidative stress defence in plants.

1. Ceruloplasmin
Ceruloplasmin, the major copper-carrying protein in the blood, plays a role iniron metabolism(227). Decreased level of ceruloplasmin impaired ferroportin stability(229)(230)may induce progressive action tremor, and cognitive decline(227), causing the forming of superoxide anion radicals(231) and iron overload in the brain, liver, pancreas, and other organs(232).

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(227) Dysregulated iron metabolism in the choroid plexus in fragile X-associated tremor/ataxia syndrome. by Ariza J1, Steward C2, Rueckert F2, Widdison M2, Coffman R2, Afjei A2, Noctor SC3, Hagerman R4, Hagerman P5, Martínez-Cerdeño V6.(PubMed)
(228) Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease byYoo MH1, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL.(PubMed)
(229) Biological effects of mutant ceruloplasmin on hepcidin-mediated internalization of ferroportin. by Kono S1, Yoshida K, Tomosugi N, Terada T, Hamaya Y, Kanaoka S, Miyajima H.(PubMed)
(230) Ceruloplasmin-ferroportin system of iron traffic in vertebrates. by Musci G1, Polticelli F1, Bonaccorsi di Patti MC1.(PubMed)
(231) Ceruloplasmin: an acute phase reactant that scavenges oxygen-derived free radicals. by Goldstein IM, Kaplan HB, Edelson HS, Weissmann G.(PubMed)
(232) Protective effect of hesperidin in a model of Parkinson's disease induced by 6-hydroxydopamine in aged mice by Antunes MS1, Goes AT1, Boeira SP1, Prigol M1, Jesse CR2.(PubMed)

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