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Friday, 23 December 2016

The holistic Prevention, Management and Treatment of Dementia - The Antioxidant Metals binding proteins Transferrin

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.



           The Antioxidant Metals binding proteins Transferrin


The expression of metal-binding proteins or peptides in microorganisms and plants in order to enhance heavy metal accumulation and/or tolerance has great potential, according to Dr. Malin Mejárea, Leif Bülow in the study of Metal-binding proteins and peptides in bioremediation and phytoremediation of heavy metals, leading to reduced oxidative stress defense in plants


5. Transferrin
Transferrin, a glycoprotein binded iron very tightly but reversibly, enhances the immune system in fighting against infection, inflammation(250) by creating an environment low in free iron(251) impeded to cell oxidation(253)(254), through rapidly evolving sites reverse to bacterial binding in counteract bacterial iron piracy(250). Transferrin deformation and aggregation are found to associate to neurological disorders such as Parkinson's and Alzheimer's disease(252).



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References
(250) Nutritional immunity. Escape from bacterial iron piracy through rapid evolution of transferrin by Barber MF1, Elde NC2.(PubMed)
(251) Total iron binding capacity and transferrin concentration in the assessment of iron status by Kasvosve I1, Delanghe J.(PubMed)
(252) Fibrillation of transferrin by Booyjzsen C1, Scarff CA, Moreton B, Portman I, Scrivens JH, Costantini G, Sadler PJ.(PubMed)
(253) The formation of Fe3+-transferrin-CO3(2-) via the binding and oxidation of Fe2+ by Kojima N, Bates GW.(PubMed)
(254) Iron released from transferrin at acidic pH can catalyse the oxidation of low density lipoprotein. by Lamb DJ1, Leake DS.(PubMed)