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Tuesday, 27 December 2016

The holistic Prevention, Management and Treatment of Dementia - Common antioxidants (scavengers) Carotenoids

Kyle J. Norton (Scholar) 
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


                                 Dementia

Dementia is defined as neuro degeneration syndrome among elder, affecting memory, thinking, orientation, comprehension, calculation, learning capacity, language, and judgement over 47 millions
of worldwide population, mostly in the West. The evaluation of the syndrome by holistic medicine has been lacking, especially through conventional medicine research and studies.



                  Common antioxidants (scavengers) Carotenoids

The expression of added to a mixture in order to remove or de-activate impurities and unwanted oxygen in the cellular level for reduced risk of oxidative stress defence in plants and animals.


2. Carotenoids
Carotenoids are organic pigments, occurred in the chloroplasts and chromoplasts of plants and some other photosynthetic organisms like algae, some bacteria. The antioxidant has been under intense scrutiny studies for finding of their potential in modulated chronic disease risk and prevention of vitamin A deficiency(267). Plasma levels of HDL and carotenoids have shown to lower in patients with dementia related vascular disorders(268) and Alzheimer's disease(AD)(269).

Beta-Carotene, an organic compound is classified as a terpenoid, a strongly-coloured red-orange pigment in plants and fruits.
Beta-Carotene is not toxic and stored in liver for the production of vitamin A(270) showed to inhibit cancer cell in experiment(271)(272). Its anti oxidative effects has shown to cover the main pathways for formation, transformation, and decay of free radicals(273), through its relation to the antioxidant/pro-oxidant properties(274). According to Yale University, the decreased non-enzymatic antioxidants in blood, including β-carotene showed a significant oxidative damage in the process of neurodegeneration(275).


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References
(267) Absorption, metabolism, and transport of carotenoids. by Parker RS1.(PubMed)
(268) Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities. by Dias IH1, Polidori MC2, Li L1, Weber D3, Stahl W4, Nelles G5, Grune T3, Griffiths HR1.(PubMed)
(269) Retinoids as potential targets for Alzheimer's disease by Sodhi RK1, Singh N2.(PubMed)
(270) The importance of beta-carotene as a source of vitamin A with special regard to pregnant and breastfeeding women by Strobel M1, Tinz J, Biesalski HK.(PubMed)
(271) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group.[No authors listed](PubMed)
(272) Lipid-soluble antioxidants: beta-carotene and alpha-tocopherol levels in breast and gynecologic cancers by Palan PR1, Goldberg GL, Basu J, Runowicz CD, Romney SL(PubMed)
(273) Beta-carotene as an interceptor of free radicals. by Ozhogina OA1, Kasaikina OT.(PubMed)
(274) Evidence for a lack of reactivity of carotenoid addition radicals towards oxygen: a laser flash photolysis study of the reactions of carotenoids with acylperoxyl radicals in polar and non-polar solvents by El-Agamey A1, McGarvey DJ.(PubMed)
(275) Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysis by Schrag M1, Mueller C, Zabel M, Crofton A, Kirsch WM, Ghribi O, Squitti R, Perry G.(PubMed)