Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The diet of Olive oil

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia

                                                      Fibromyalgia

Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                 The diet

Dietary consumption plays an important part in reduce or increase risk of chronic inflammatory diseases. A typical American diet with high amount of red meat, fat and trans fat, processed, meat, artificial ingredients, refined products are associated to promote the expression of pro inflammatory cytokines, leading to all kinds of diseases including chronic inflammatory, cardiovascular diseases and diabetes.

3. Olive oil
Olive is belongs to the the family Oleaceae, native to the coastal areas of the eastern Mediterranean Basin and south end of the Caspian Sea. Its fruit, is a source of olive oil.

Consumption of extra virgin olive oil (EVOO) has been found to decrease joint edema, cell migration, cartilage degradation and bone erosion throguh attenuate the levels of proinflammatory cytokines and prostaglandin E2(114). according joint study by the University of Seville.In adult male Balb/C mice study, olive oil decreased the second phase of formalin-induced pain through its antinociceptive and anti-inflammatory activity(115).
The Chemistry and health of olive oil phenolics study also found, the positive effects of olive oil phenolics on certain physiological parameters, such as plasma lipoproteins, oxidative damage, inflammatory markers, platelet and cellular function, etc,.....(116).
Omega 3 fatty acids found abundantly in olive, according to university if Toronto exhibited anti neuropathic pain activities(117) and suggested that the oil fatty acids may be used for management of symptoms in patients with fibromyalgia(118).

Dr. Ozgocmen S and colleagues at the Firat University said, " patients with FM are under oxidative stress" and "These findings represent a rationale for further research assessing the effect of free radical scavengers or antioxidant agents like vitamins and omega-3 fatty acids on peripheral and central mechanisms in FM.
In the evaluation of the oxidant/antioxidant status, lipid peroxidation and nitric oxide (NO) in untreated fibromyalgia (FM) patients and controls(119).

Similar to olive, nuts and seeds with rich in Omega 3 fatty acids is necessary to reduce risk of expressionless of markers of inflammation to attenuate the inflammatory response of the immune system, according to the study by the Tufts University(120).
High saturated fat diets with low omega 3 fatty acid intake increased omega-6:EPA+DHA ratio diets causing some measures of inflammation(121).

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References

(114) Anti-inflammatory and joint protective effects of extra-virgin olive-oil polyphenol extract in experimental arthritis by Rosillo MÁ1, Alcaraz MJ2, Sánchez-Hidalgo M1, Fernández-Bolaños JG3, Alarcón-de-la-Lastra C1, Ferrándiz ML4.(PubMed)
(115) Antinociceptive and anti-inflammatory effects of olive oil (Olea europeae L.) in mice. by Eidi A1, Moghadam-kia S, Moghadam JZ, Eidi M, Rezazadeh S.(PubMed)
(116) Chemistry and health of olive oil phenolics by Cicerale S1, Conlan XA, Sinclair AJ, Keast RS.(PubMed)

(117) Omega-3 fatty acids for neuropathic pain: case series by Ko GD1, Nowacki NB, Arseneau L, Eitel M, Hum A.(PubMed)

(118) Effect of omega-3 fatty acids in the management of fibromyalgia syndrome by Ozgocmen S, Catal SA, Ardicoglu O, Kamanli A.(PubMed)

(119) Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns by Ozgocmen S1, Ozyurt H, Sogut S, Akyol O, Ardicoglu O, Yildizhan H.(PubMed)

(120) In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation by Wang S1, Wu D, Lamon-Fava S, Matthan NR, Honda KL, Lichtenstein AH.(PubMed)

(121) Reduction in dietary omega-6 polyunsaturated fatty acids: eicosapentaenoic acid plus docosahexaenoic acid ratio minimizes atherosclerotic lesion formation and inflammatory response in the LDL receptor null mouse by Wang S1, Wu D, Matthan NR, Lamon-Fava S, Lecker JL, Lichtenstein AH.(PubMed)