Sunday, 19 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - The Free Radical scavengers - Vitamin E

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

                            The Free Radical scavengers

4. Vitamin E
According to Dr. Moriguchi S and Dr. Muraga M., vitamin E plays an essential role in enhanced immunity especially in cellular immunity with aging(171). Deficiency of vitamin E is found to induces the decreased differentiation of immature T cells associated to the increased infectious diseases and the incidence of tumors(171). According to the Suleyman Demirel University, intake of vitamins C and E (VCE) supplementation with exercise (EX) enhanced antioxidant vitamin and lipid peroxidation (LP) levels in blood of patients with fibromyalgia (FM)in protection of against FM-induced by oxidative stress(172).
Dr. Altindag O and Dr. Celik H. said, " patients with fibromyalgia are exposed to oxidative stress and this increased oxidative stress may play a role in the etiopathogenesis of the disease. Supplementation of antioxidant vitamins such as vitamins C and E to the therapy may be indicated"(173).
In support to the above analysis, Dr. Bagis S and colleagues at the Mersin University Medical School insisted, change of oxidant/antioxidant balances induced increase of free radical levels may be responsible for the development of fibromyalgia(174).
In fact, dietary consumption including vitamin E significantly reduced the levels of inflammation by analyzing the pro and anti-inflammatory cytokines in the blood serum(175).

(171) Vitamin E and immunity by Moriguchi S1, Muraga M.(PubMed)
(172) Vitamins C and E treatment combined with exercise modulates oxidative stress markers in blood of patients withfibromyalgia: a controlled clinical pilot study by Nazıroğlu M1, Akkuş S, Soyupek F, Yalman K, Çelik Ö, Eriş S, Uslusoy GA.(PubMed)
(173) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia by Altindag O1, Celik H.(PubMed)
(174) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder? by Bagis S1, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C.(PubMed)
(175) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)

No comments:

Post a comment