Tuesday, 28 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - The Medications of Simple analgesics(

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A.2. Medications
The aim of medicine is to relieve the symptoms of the disease
In a narrative review by the Indiana University School of Medicine, from meta-analyses and systematic reviews published since 2005. For a few medications, findings from multiple recent trials are synthesized if a systematic review had not yet been published. Classes of medications are first reviewed, include(211).
1. Simple analgesics(acetaminophen or nonsteroidal anti-inflammatory drugs)
The objective of analgesics is to reduce pain for patient with Fibromyalgia through their effects on the peripheral and central nervous system.
According to the National Cheng Kung University, R-Duloxetine and N-Methyl Duloxetine, the Novel Analgesics effectively alleviates intractable pain associated with diabetic peripheral neuropathy and fibromyalgia(212).
In a randomised, double-blind studies of eight weeks' duration or longer, comparing milnacipran with placebo or another active treatment in fibromyalgia in adults suggested, "Evidence available indicates that milnacipran 100 mg or 200 mg is effective for a minority in the treatment of pain due to fibromyalgia, providing moderate levels of pain relief (at least 30%) to about 40% of participants, compared with about 30% with placebo"(213).
 Most common adverse effects, according to share care include allergic(hoarseness, swelling, difficulty breathing, hives, itching, and rash)  gastrointestinal(stomach upset,constipation, diarrhea) symptoms and  dizziness, or headache(214)

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(211) Pharmacotherapy of chronic pain: a synthesis of recommendations from systematic reviews by Kroenke K1, Krebs EE, Bair MJ.(PubMed)
(212) R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain. by Wang CF1, Russell G, Wang SY, Strichartz GR, Wang GK.(PubMed)
(213) Milnacipran for pain in fibromyalgia in adults by Cording M1, Derry S, Phillips T, Moore RA, Wiffen PJ.(PubMed)
(214) What are the side effects of analgesics? by  Share care

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