Friday, 10 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The diet of Circuit fruits

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                  The diet

Dietary consumption plays an important part in reduce or increase risk of chronic inflammatory diseases. A typical American diet with high amount of red meat, fat and trans fat, processed, meat, artificial ingredients, refined products are associated to promote the expression of pro inflammatory cytokines, leading to all kinds of diseases including chronic inflammatory, cardiovascular diseases and diabetes.
4. Circuit fruits
Circuit fruit contain high amount of Quercetin which can reduce the risk of chronic inflammatory diseases as a result of anti inflammatory(122) and antioxidant effects(123). Vitamin C, also known as L-ascorbate is a water soluble vitamin with a chemical structure formula of C6H6O6 found abundantly in circuit fruit, enhanced the activation of immune cells such as T and NK cells in attenuation of the inflammation caused by viral infection when used conjunction with red ginseng(124).
Dr. Yan H and colleagues in the study of Ascorbic acid (AA) in mitigating oxidative stress and inhibiting inflammation suggested, ascorbic acid significantly reduced clinical signs, inflammatory cytokines, myeloperoxidase (MPO) and malonaldehyde (MDA) activities in animal model(125).
Furthermore, the application of vitamin C and Quercetin, in exposure to fine particulate matter (PM2.5), exhibited the repressive roles in respiratory oxidative damage caused by PM2.5, through attenuated the depleted the cell viability of 16HBE cells, the elevated reactive oxygen species (ROS) generation, and the inhibited mitochondrial genes expressions(126).
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(122) In vivo quercitrin anti-inflammatory effect involves release of quercetin, which inhibits inflammation through down-regulation of the NF-kappaB pathway by Comalada M1, Camuesco D, Sierra S, Ballester I, Xaus J, Gálvez J, Zarzuelo A.(PubMed)
(123) Health effects of quercetin: from antioxidant to nutraceutical by Boots AW1, Haenen GR, Bast A.(PubMed)
(124) Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection by Kim H1,2, Jang M1, Kim Y1, Choi J1, Jeon J1, Kim J3, Hwang YI1, Kang JS1,2, Lee WJ1.(PubMed)
(125) Ascorbic acid ameliorates oxidative stress and inflammation in dextran sulfate sodium-induced ulcerative colitis in mice by Yan H1, Wang H2, Zhang X3, Li X1, Yu J1.(PubMed)
(126) Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells by Jin X1, Su R1, Li R2, Song L1, Chen M1, Cheng L3, Li Z4.(PubMed)

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