Wednesday, 1 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - Reduce intake of saturated and trans fat

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                       Prevention and Management

The Do and do not’s list
What to avoid may be the first question of people age of 50 and over who concern that they may be in stage of developing the disease. Other people may want to know what they can do to protect themselves against the early onset.

1. Reduce intake of saturated and trans fat and increase intake of omega 3 fatty acids
Omega-3, 6,9 fatty acids are phytochemincals in the class of Lipids, found abundantly in dark-green leafy vegetables, grains, legumes, nuts, etc.
Intake of omega-3 fatty acids may be used to treat and in the manage symptoms of fibromyalgia syndrome, according to Dr. Ozgocmen S and colleagues(81) due to its antioxidant effect in ameliorated oxidative stress and nitric oxide in the pathophysiology of FM(82).  Although Limited studies have shown that certain dietary fatty acids (ie, oleic acid and alpha-linolenic acid) reduce biomarkers of inflammation(77).
Dr. Li Z and the research team at the Jilin University showed that ω3-polyunsaturated fatty acids (ω3-PUFAs) not only have beneficial effects on cardiovascular function but also promoted the docosahexaenoic acid (DHA) in reduced inflammation(78)(79).
The results of over 13 double-blind, placebo-controlled studies involving a total of more than 500 people suggest that omega-3 fatty acids may improve symptoms of rheumatoid arthritis. One of the ways it appears to work is by decreasing the production of inflammatory chemicals(80). 
Maintaining high levels of omega-3 fatty acids showed to neutralizing the saturated and trans fat involved high blood cholesterol in elevation of fibromyalgia pain caused by exhibited the function of pro inflammatory cytokines(83)(84)(85).

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(77) The effect of weight loss and dietary fatty acids on inflammation by Devaraj S1, Kasim-Karakas S, Jialal I.(PubMed)
(78) Effects of the Dietary ω3:ω6 Fatty Acid Ratio on Body Fat and Inflammation in Zebrafish (Danio rerio). by Powell ML1, Pegues MA2, Szalai AJ2, Ghanta VK3, D'Abramo LR4, Watts SA3.(PubMed)
(79) ω3-polyunsaturated fatty acids suppress lipoprotein-associated phospholipase A2 expression in macrophages and animal models vt Li Z1, Ren W1, Han X1, Liu X1, Wang G1, Zhang M1, Pang D1, Ouyang H1, Tang X1.(PubMed)
(80) Overview of Omega-3 Fatty Acid Therapies by J. Chris Bradberry, PharmD and Daniel E. Hilleman, PharmD(PubMed)
(81) Effect of omega-3 fatty acids in the management of fibromyalgia syndrome by Ozgocmen S, Catal SA, Ardicoglu O, Kamanli A.(PubMed)
(82) Current concepts in the pathophysiology of fibromyalgia: the potential role of oxidative stress and nitric oxide by Ozgocmen S1, Ozyurt H, Sogut S, Akyol O.(PubMed)
(83) Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function by Valdearcos M1, Robblee MM2, Benjamin DI3, Nomura DK3, Xu AW4, Koliwad SK5.(PubMed)
(84) Influence of dietary saturated fat content on adiposity, macrophage behavior, inflammation, and metabolism: composition matters by Enos RT1, Davis JM, Velázquez KT, McClellan JL, Day SD, Carnevale KA, Murphy EA.(PubMed)
(85) Effect of industrially produced trans fat on markers of systemic inflammation: evidence from a randomized trial in women by Bendsen NT1, Stender S, Szecsi PB, Pedersen SB, Basu S, Hellgren LI, Newman JW, Larsen TM, Haugaard SB, Astrup A.(PubMed)

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