Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Types of Musculo-Skeletal disorders in elder
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
7. Low back pain
Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.
Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.
Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).
Anti inflammatory Antioxidants play an critical role in induction of oxidative stress in the pathogenesis of a number of disorders inflammation, Fibromyalgia , rheumatoid arthritis, asthma, psoriasis and contact dermatitis(176),
Methylsulfonylmethane, also known DMSO2 is an organosulfur compound with the formula (CH3)2SO2 showed to exhibit anti inflammatory effects in attenuated production of mitochondrial reactive oxygen species (ROS)(185).
In a randomized, double-blind, placebo-controlled trial of Fifty men and women, 40-76 years of age MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events, after 12 weeks(186)(187).
According to the joint study led by the Kangwon National University, Methylsulfonylmethane (MSM) inhibited expression of NLRP3(plays a crucial role in innate immunity and inflammation) in attenuated production of mitochondrial reactive oxygen species (ROS) and pro inflammatory cytokines such as IL-1α, IL-1β, IL-6(188).
In support of the use of sulfur organic compound of Methylsulfonylmethane as clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS, Dr. Parcell S said, " Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, DMSO, and glucosamine sulfate. ......MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders"(181).
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(185) Methylsulfonylmethane inhibits NLRP3 inflammasome activation by Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.(PubMed)