Thursday, 30 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia Treatment - The Medications of Gabapentin, duloxetine or pregabalin if neuropathic pain

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                        The Treatment

In conventional medicine perspective
FM usually involves females, particular to women entering stage of menopause. But it is often diagnosed both in young as well as elderly individuals. Diagnosis of pediatric FMS is a lengthy and frustrated condition affecting children and adolescents physical and emotional development, as the disease mimicked a spectrum of inflammatory joint disorders such as juvenile idiopathic arthritis (JIA), juvenile ankylosing spondylitis, etc, according to the study by Soroka Medical Center, Beer-Sheva(193)
A.2. Medications
3. Gabapentin, duloxetine or pregabalin if neuropathic pain
Neuropathic pain is a improper healing of injure tissue causing nerve fiber damage in sending uncorrected information to other pain centers, medication used for treatment of neuropathic pain of patient with fibromyalgia may include Gabapentin, duloxetine or pregabalin.
According to the Aristotle University of Thessaloniki, in the review of data base of research literature suggested, pregabalin (PB) at a dose of 450 mg per day is most likely effective in treating FBM, although AE are not negligible(219). Other study suggested gabapentin at doses of 1200 mg or more was effective for some people with some painful neuropathic pain conditions(220), including fibromyalgia.
The most common side effects of above medicine used for treatment of neuropathic pain include bot not limit to
Dizziness, drowsiness, dry mouth, edema (accumulation of fluid), blurred vision, double vision (diplopia), weight gain, fatigue (tiredness), tremor and difficulty concentrating,... according to medicine net(221).

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(219) Gabapentin and pregabalin in the treatment of fibromyalgia: a systematic review and a meta-analysis by Tzellos TG1, Toulis KA, Goulis DG, Papazisis G, Zampeli VA, Vakfari A, Kouvelas D.(PubMed)
(220) Gabapentin for chronic neuropathic pain and fibromyalgia in adults by Moore RA1, Wiffen PJ, Derry S, Toelle T, Rice AS.(PubMed)
(221) side effects of pregabalin by Medicine net

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