Monday, 13 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Phytochemicals: Resveratrol

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The  Phytochemicals

Different mediators of central inflammation in dysfunctional and inflammatory pain have been found to associate with patient with Fibromyalgia(127). Certain phytochemicals have found effectively for treatment of inflammatory symptoms of patient with FM, including the following

3. Resveratrol
Resveratrol (RES), a well-known antioxidant and anti-inflammatorycompound, is abundant in red wine and exerts numerous pharmacological effects, including hepatoprotection and cadioprotection(137).
The antioxidant exhibited anti-inflammatory effects through ameliorated the expression of proinflammatory (e.g., miR-155) in infections, injuries, atherosclerosis, diabetes mellitus, obesity, cancer, osteoarthritis, age-related macular degeneration, demyelination, and neurodegenerative diseases(138).
In the evaluation of the medical effect of resveratrol, the University of Wuxi, Jiangsu, insisted" Resveratrol prevented the accumulation of chronic oxidative stress and suppression of Tregs production in HFD mice, modulated changes of cytokines in the plasma and spleen, and decreased expressions of inflammatory mediators compared with those of the DIO group"(139).
Furthermore, the antioxidant also expressed anti age-associated chronic diseases through exhibited dysregulation of multiple cell signaling pathways in induction of inflammation(140).According to the University of Arizona study, resveratrol facilitated acute and chronic pain through activation of AMPK, the enzyme played a key role as a master regulator of cellular energy homeostasis(141).
In a Mouse Fibromyalgia-Like Model, resveratrol significantly reduced mechanical allodynia and thermal hyperalgesia in attenuated oxidative stress and reactive species, underlying mechanism of pathogenesis of the disease. through antinociceptive and antidepressant actions(142)

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(137) Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways by Lee CW1, Yen FL, Huang HW, Wu TH, Ko HH, Tzeng WS, Lin CC.(PubMed)
(138) Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation by Latruffe N1, Lançon A1, Frazzi R2, Aires V1,3, Delmas D1,3, Michaille JJ1, Djouadi F4, Bastin J4, Cherkaoui-Malki M1.(PubMed)
(139) Resveratrol prevents suppression of regulatory T-cell production, oxidative stress, and inflammation of mice prone or resistant to high-fat diet-induced obesity by Wang B1, Sun J, Li X, Zhou Q, Bai J, Shi Y, Le G.(PubMed)
(140) Resveratrol: a multitargeted agent for age-associated chronic diseases by Harikumar KB1, Aggarwal BB.(PubMed)
(141) Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain by Tillu DV1, Melemedjian OK, Asiedu MN, Qu N, De Felice M, Dussor G, Price TJ.(PubMed)
(142) Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model by Peres Klein C1, Rodrigues Cintra M2, Binda N3, Montijo Diniz D3, Gomez MV3, Souto AA4, de Souza AH5.(PubMed)

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