Wednesday, 15 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia -The Free Radical scavengers- Vitamin C

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

The Antioxidants

Free radicals are atoms, molecules, or ions with unpaired electrons through chemical bonds with other atoms or molecules during a chemical reaction. They may have positive, negative or zero charge.

Free Radicals play an important role in the function of the Immune System. The immune system produces free radicals to kill foreign microbes(152)(153), but the production of free radical sometime can be excessive, leading to formation of a large number of free radicals(154)(155). The domino effects have shown to induce many chronic illness, such as cancers(155).
Furthermore, free radicals also displays over expression of oxidative stress, inducing varies form of chronic illness including metabolic syndrome(156).

                            The Free Radical scavengers

2. Vitamin C
Vitamin C, also known as L-ascorbate, a water soluble vitamin with a chemical structure formula of C6H6O6  is best known for it's antioxidant property in strengthening the immune system.Due to recent promotion of western diet in some developed country, deficiencies of micronutrients are emerging as the limiting factors in ensuring children's optimal health, according Bayer Consumer Care Ltd(162). Deficiency of vitamin C and zinc in fact, interfere with normal children's growth and development(162). Researchers found that vitamin C raised the concentration in the blood of total immunoglobulin(163) in promotion of the ability of antibodies and phagocytic cells to clear pathogens(164).
Dr. Altindag O and Dr. Celik H. said, " patients with fibromyalgia are exposed to oxidative stress and this increased oxidative stress may play a role in the etiopathogenesis of the disease. Supplementation of antioxidant vitamins such as vitamins C and E to the therapy may be indicated"(165).
According to the University of Kuopio,  vegan diet rich in antioxidants, lactobacilli and fibre, have shown to benefit patient with rheumatoid disorder(166).

(162) Essential role of vitamin C and zinc in child immunity and health by Maggini S1, Wenzlaff S, Hornig D.(PubMed)
(163) New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate by Hae-Suk Kim,a Michael J. Quon,c and Jeong-a Kima,b(PMC)
(164) Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications by Singh BN1, Shankar S, Srivastava RK.(PubMed)
(165) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia by Altindag O1, Celik H.(PubMed)
(166) Antioxidants in vegan diet and rheumatic disorders by Hänninen1, Kaartinen K, Rauma AL, Nenonen M, Törrönen R, Häkkinen AS, Adlercreutz H, Laakso J.(PubMed)