Thursday, 2 June 2016

Most Common Disease of 50plus: The Clinical trials and Studies of Musculo-Skeletal disorders(MSDs) - Fibromyalgia - Increasing the ratio of (n-3) : (n-6) PUFA

Kyle J. Norton (Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are  medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

      Types of Musculo-Skeletal disorders in elder

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia


Fibromyalgia, according to the American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the newly proposed criteria for the classification of fibromyalgia are 1) widespread pain in combination with 2) tenderness at 11 or more of the 18 specific tender point sites(a) as a result in responding to pressure.

                 Prevention and Management

The Do and do not’s list
2. Increasing the ratio of (n-3) : (n-6) PUFA
It is believed that omega-3 (n-3) polyunsaturated fatty acids (PUFA) suppress and n-6 PUFA have caused many kinds of disease, epidemiologically such as prostate cancer(90), colorectal cancers(91), breast cancer(92).
The industrial elocution induced Western style diet in over consumption of ω6 polyunsaturated fatty acids (PUFA) over many decades has been found to distort the ratio of ω3:ω6 fatty acids, one of the leading cause of chronic inflammatory diseases, including Fibromyalgia(78).
Increased ratio of (n-6) : (n-3) PUFA are found to promote chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer’s disease (AD)(86).
According to Dr. Yang LG and colleagues led by the Southeast University, an imbalance in the n-6/n-3 polyunsaturated fatty acid (PUFA) ratio, ameliorated lipid profiles, anti-inflammatory and anti-oxidative stress effects(87) in induction the widespread pain in patients with FM(88). Pro inflammatory cytokines of interleukin (IL)-1β is found to inversely associate higher cerebrospinal fluid (CSF) in induced dysfunctional pain (FM) in patients with FM(89).

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(86) Health implications of high dietary omega-6 polyunsaturated Fatty acids by Patterson E1, Wall R, Fitzgerald GF, Ross RP, Stanton C.(PubMed)
(87) Low n-6/n-3 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stress and Endothelial Function in Rats Using Plant Oils as n-3 Fatty Acid Source by Yang LG1, Song ZX1,2, Yin H1,3, Wang YY1, Shu GF4, Lu HX4, Wang SK1, Sun GJ5.(PubMed)
(88) The inflammatory hypothesis of mood spectrum broadened to fibromyalgia and chronic fatigue syndrome by Dell'Osso L1, Bazzichi L2, Baroni S1, Falaschi V1, Conversano C1, Carmassi C1, Marazziti D1.(PubMed)
(89) Evidence of different mediators of central inflammation in dysfunctional and inflammatory pain--interleukin-8 infibromyalgia and interleukin-1 β in rheumatoid arthritis by Kosek E1, Altawil R2, Kadetoff D3, Finn A4, Westman M2, Le Maître E2, Andersson M5, Jensen-Urstad M6, Lampa J2.(PubMed)

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