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Thursday, 16 April 2015

Top 4 Fruits for Reducing Risk of Benign prostatic hyperplasia(BPH)

Benign prostatic hyperplasia(BPH) is defined as a condition of increased in the number of cells of prostate gland, causing partial, or sometimes virtually complete obstruction of the urinary tract. According to statistic, BPH commonly starts at age of 30 and symptoms usually can not be realized until age of 50. More than half of men between age of 60-70 are experience symptoms of BPH and only 10% are required treatment. Suggestion of BPH is associated to nutritional status and eating habits, according to the study, 30 male patients with clinically confirmed and treated disease of the prostatic gland, including 15 men (aged 51-75 years) with BPH and 15 men (aged 51-73 years) with PC, indicated improper nutritional status lead of incorrect nutritional habits which fail to improve their health status, may be the cause of  the development of some diet-dependent diseases, such as BPH and prostate cancer(a). A proper diet with vegetable, fruit containing zinc may reduce the risk of the disease from starting(b)(c).
  Epidemiological studies, indicated intake of vegetables and fruits accompanied with healthy life style may be associated in prevented risk and treatment of enlarged prostate(d)(e)(f), it may due to enhancement of antioxidants effect on over production of prostate cells(g)(h).

4 Fruits for reducing risk of Benign prostatic hyperplasia(BPH)
1. Orange
Orange is a species of Citrus Sinensis, belong to the family Rutaceae and native to the Southeast Asia. Orange is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world. The extract of red orange juice (ROE)  showed to inhibit proliferation of fibroblast and epithelial prostate cells, and may be a potential usefulness in the management of benign prostatic hyperplasia, according to University of Rome(22).

2. Water melon and strawberry
Lycopene, a member of the carotenoid family, found abundantly in Water melon, strawberry, exerted its antioxidants effect as preventive agent for prostate disease(23). The study of Profluss® on prostatic chronic inflammation (PCI) in 168 subjects, the compositions included serenoa repens+Selenium+Lycopene exhibited its anti-inflammatory activity for treatment of PCI in BPH and/or PIN/ASAP patients(24). The study by University of Messina, found that Serenoa repens, lycopene and selenium is superior than Serenoa repens alone in reducing benign prostatic hyperplasia, through reduction of  prostate weight and hyperplasia and cell proliferation and growth factor expression augmentation of apoptosis(25).

3. Cranberry
Cranberry is a species of Vaccinium oxycoccos, belong to the family Ericaceae. It is low, creeping shrubs or vines up to 2 m long and 5 to 20 cm in height and found in the cooler part of Northern America. In the study to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, showed a positive effects with lower total PSA level on day 180 of the study(26) and lower urinary tract symptoms of benign prostatic hyperplasia(27), In a total of 370 consecutive patients study, cranberry found to reduced urinary tract symptoms (dysuria, nocturia, urinary frequency, urgency) of that may be  in reduced risk of BPH(28).
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References
(a) Nutritional status and nutritional habits of men with benign prostatic hyperplasia or prostate cancer - preliminary investigation by Goluch-Koniuszy Z, Rygielska M, Nowacka I.(PubMed)
(b) Diet and benign prostatic hyperplasia: a study in Greece by Lagiou P1, Wuu J, Trichopoulou A, Hsieh CC, Adami HO, Trichopoulos D.(PubMed)
(c) Associations of obesity, physical activity and diet with benign prostatic hyperplasia and lower urinary tract symptoms by Raheem OA1, Parsons JK.(PubMed)
(d) Nutrition and benign prostatic hyperplasia by Espinosa G.(PubMed)
(e) Dietary patterns and prostatic diseases by Sebastiano C1, Vincenzo F, Tommaso C, Giuseppe S, Marco R, Ivana C, Giorgio R, Massimo M, Giuseppe M.(PubMed)
(f) Fruit and vegetable consumption, intake of micronutrients, and benign prostatic hyperplasia in US men by Rohrmann S1, Giovannucci E, Willett WC, Platz EA.(PubMed)

(22) Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro by Vitali F1, Pennisi C, Tomaino A, Bonina F, De Pasquale A, Saija A, Tita B.(PubMed)
(23) Lycopene for the prevention and treatment of prostate disease by Ilic D.(PubMed)
(24) Effects of Serenoa repens, selenium and lycopene (Profluss®) on chronic inflammation associated with benign prostatic hyperplasia: results of "FLOG" (Flogosis and Profluss in Prostatic and Genital Disease), a multicentre Italian study by Morgia G1, Cimino S, Favilla V, Russo GI, Squadrito F, Mucciardi G, Masieri L, Minutoli L, Grosso G, Castelli T.(PubMed)
(25) [The association of Serenoa repens, lycopene and selenium is superior to Serenoa repens alone in reducing benign prostatic hyperplasia].[Article in Italian] by Squadrito F1, Morgia G.(PubMed)
(26) The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms by Vidlar A1, Vostalova J, Ulrichova J, Student V, Stejskal D, Reichenbach R, Vrbkova J, Ruzicka F, Simanek V.(PubMed)
(27) Risk factors for lower urinary tract symptoms suggestive of benign prostatic hyperplasia in a community based population of healthy aging men: the Krimpen Study by Kok ET1, Schouten BW, Bohnen AM, Groeneveld FP, Thomas S, Bosch JL.(PubMed)
(28) Enteric-coated, highly standardized cranberry extract reduces risk of UTIs and urinary symptoms during radiotherapy for prostate carcinoma by Bonetta A1, Di Pierro F.(PubMed)