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By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovasular disease(8)(13), acne(10)(14), endometrial cance(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasing altered glucose tolerance(20), CVD and hypertension(21).
The prevention and management
Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Although PCOS cannot be completely avoided, strengthening immunity has shown a significant reduction of chronic inflammatory diseases(266)(267)(268).
The Immunity Boosting Minerals
Recent studies showed that deficiencies of zinc, iron, copper, and selenium lower resistance to disease either due to impaired immune response or faulty white blood cells' function(421)
The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(422) that significantly increases for both IgA and IgG, the antibody molecules that protect our body against bacterial and viral infections(423) and the lining of the respiratory passages, gastrointestinal and genitourinary tract(423).
The mineral also found to increase neutrophil function and enzyme peroxidase activity and reduce the incidence of health disorders by boosting immunity(424), including chronic inflammatory disease(425)(426). Low serum magnesium (Mg) is often associated with incidences of insulin resistance (IR), cardiovascular problems, diabetes mellitus, hypertension and other components of metabolic syndrome(428) in patients with polycystic ovary syndrome (PCOS)(427).
Selenium, a trace mineral plays an important and indirect role as an antioxidant(429)(430) by fulfilling its function as a necessary constituent of glutathione peroxidase(431)(432) and in production of glutathione(432), that inhibits the damage caused by oxidation of free radical hydrogen peroxide(433).
Extensively epidemiological studies suggested that selenium also benefits to health aspects, including anti cancers(434)(435), lowering cholesterol(436)(438), hypertension(439)(440), treating heart disease(427)(438), boosting immunity(441)(442) against microbial invasion(443)(444) and anti chronic inflammatory disease(445)(446).
Zinc besides is an important mineral in boosting immune system activity(447)(449). Its nano-structure zinc(II) coordination compounds, has been used in zinc therapy to treat candida overgrowth(449) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(450) through its anti inflammatory activity(451), including chronic inflammation(453)(454) via immune modulatory effects(452)(453)(454).
In larger amounts, manganese can be poisoning to neurological damage(451)(462).
A mineral plays a vital role for production of hemoglobin(463)(464)utilised by the body for oxygen transport and energy production(467), for maintaining healthy bones(465) and neurotransmission(466), synthesizing of some hormones and connective tissue(467)(468)(469) and maintaining heart health(470). Deficiency of iron causes low level of hemoglobin, nervous tension((473)(474)), cognitive dysfunction(471)(476), heart disorders(472)(475), heavy menstrual bleeding(479)(480), iron deficiency anemia, etc.,.. Recent studies suggested that trace mineral iron improves immunity(481)(482) fighting against microbial infection(481) and inflammatory disease(483)(484), including certain types of chronic inflammatory diseases(486)(485) due to low levels of hemoglobin impaired cell-mediated immune response and bacterial activity of leukocytes(421).
Copper is vital in maintaining the production of antibodies(487)(488), white blood cells(489)(490), antioxidant enzymes(491)(492), for increasing the immune function in fighting against infection(487)(488) and inflammation(493)(494), including certain chronic inflammatory diseases(495)(496). The mineral also acts as a modulator of neuronal transmission(497), regulates production of certain hormones(498). Deficiency of copper may cause metabolic liver disease(502), copper deficiency anemia(503),....Deficiency and excess of copper levels can induce infertile(499), low libido and sexual issues(500), low quality sperm production(499)(500), disrupted nervous function(501), etc.,...
Ovarian Cysts And PCOS Elimination
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndrome and healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(266) [Immunopathological responses in women with chronic inflammatory diseases of the uterus and appendages and their therapeutic correction].[Article in Russian] by Medvedev BI1, Kazachkova EA, Kazachkov EL.(PubMed)
(267) Cross Talk Between ER Stress, Oxidative Stress, and Inflammation in Health and Disease by Dandekar A1, Mendez R, Zhang K.(PubMed)
(268) New dog and new tricks: evolving roles for IL-33 in type 2 immunity by Lott JM1, Sumpter TL1, Turnquist HR2.(PubMed)
(421) Trace Minerals and ImmunologyRichard C. Bull, Professor of Animal Sciences, University of Idaho
(424) Effect of an injectable trace mineral supplement containing selenium, copper, zinc, and manganese on immunity, health, and growth of dairy calves by Teixeira AG1, Lima FS1, Bicalho ML1, Kussler A1, Lima SF1, Felippe MJ1, Bicalho RC2.(PubMed)
(425) Effects of magnesium depletion on inflammation in chronic disease by Nielsen FH1.(PubMed)
(426) Magnesium, inflammation, and obesity in chronic disease by Nielsen FH1.(PubMed)
(427) Serum magnesium concentrations in polycystic ovary syndrome and its association with insulin resistance by Sharifi F1, Mazloomi S, Hajihosseini R, Mazloomzadeh S.(PubMed)
(428) Serum magnesium concentrations and metabolic variables in polycystic ovary syndrome by Kauffman RP1, Tullar PE, Nipp RD, Castracane VD.(PubMed)
(429) Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation by Mertens K1, Lowes DA1, Webster NR1, Talib J2, Hall L2, Davies MJ3, Beattie JH4, Galley HF5.(PubMed)
(430) Serum selenium concentration and antioxidant activity in cervical cancer patients before and after treatment by Subramanyam D1, Subbaiah KV, Rajendra W, Lokanatha V.(PubMed)
(431) Selenium regulation of glutathione peroxidase in human hepatoma cell line Hep3B by Baker RD1, Baker SS, LaRosa K, Whitney C, Newburger PE.(PubMed)
(432) Selenium: biochemical role as a component of glutathione peroxidase by Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG.(PubMed)
(433) Selenium suppressed hydrogen peroxide-induced vascular smooth muscle cells calcification through inhibiting oxidative stress and ERK activation by Liu H1, Lu Q, Huang K.(PubMed)
(434) Associations of obesity with prostate cancer risk differ between u.s. African-american and non-Hispanic white men: results from the selenium and vitamin e cancer prevention trial by Barrington WE, Schenk JM, Etzioni R, Arnold KB, Neuhouser ML, Thompson IM, Lucia MS, Kristal AR.(PubMed)
(435) Selenium for preventing cancer by Vinceti M1, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R, Del Giovane C.(PubMed)
(436) The association between selenium and lipid levels: a longitudinal study in rural elderly Chinese by Chen C1, Jin Y1, Unverzagt FW2, Cheng Y1, Hake AM3, Liang C1, Ma F1, Su L1, Liu J1, Bian J4, Li P5, Gao S6.(PubMed)
(437) Associations of selenium status with cardiometabolic risk factors: an 8-year follow-up analysis of the Olivetti Heart study by Stranges S1, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, Strazzullo P.(PubMed)
(438) Selenium status and blood lipids: the cardiovascular risk in Young Finns study by Stranges S1, Tabák AG, Guallar E, Rayman MP, Akbaraly TN, Laclaustra M, Alfthan G, Mussalo-Rauhamaa H, Viikari JS, Raitakari OT, Kivimäki M.(PubMed)
(439) Influence of serum selenium concentrations on hypertension: the Lipid Analytic Cologne cross-sectional study by Berthold HK1, Michalke B, Krone W, Guallar E, Gouni-Berthold I(PubMed)
(440) Serum selenium concentrations and hypertension in the US Population by Laclaustra M1, Navas-Acien A, Stranges S, Ordovas JM, Guallar E.(PubMed)
(441) The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities by Huang Z1, Rose AH, Hoffmann PR.(PubMed)
(442) The influence of selenium on immune responses by Hoffmann PR1, Berry MJ.(PuMed)
(443) Selenium containing heterocycles: synthesis, anti-inflammatory, analgesic and anti-microbial activities of some new 4-cyanopyridazine-3(2H)selenone derivatives by Abdel-Hafez ShH1.(PubMed)
(444) Antimicrobial selenium nanoparticle coatings on polymeric medical devices by Tran PA1, Webster TJ.(PubMed)
(445) Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis by Speckmann B1, Steinbrenner H.(PubMed)
(446) Selenium, selenoproteins and human health: a review by Brown KM1, Arthur JR.(PubMed)
(447) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(448) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)
(449) Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction. Montazerozohori M1, Musavi SA2, Naghiha A3, Zohour MM4.(PubMed)
(450) Candida article zinc and metallothionein(Cure zone)
(451) Metallothionein as an Anti-Inflammatory Mediator(Mediators of inflammation)
(452) Zinc and its role in immunity and inflammation by Bonaventura P1, Benedetti G1, Albarède F2, Miossec P3.(PubMed)
(453) Zinc: role in immunity, oxidative stress and chronic inflammation by Prasad AS1(PubMed)
(454) Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength by Hojyo S1, Miyai T2, Fujishiro H3, Kawamura M4, Yasuda T5, Hijikata A6, Bin BH7, Irié T8, Tanaka J8, Atsumi T9, Murakami M9, Nakayama M10, Ohara O11, Himeno S3, Yoshida H5, Koseki H12, Ikawa T13, Mishima K8, Fukada T14(PubMed)
(455) Frequency of autoallergy to manganese superoxide dismutase in atopic dermatitis patients: experience of three Italian dermatology centers by Guarneri F1, Costa C, Foti C, Hansel K, Guarneri C, Guarneri B, Lisi P, Stingeni L.(PubMed)
(456) IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis by Schmid-Grendelmeier P1, Flückiger S, Disch R, Trautmann A, Wüthrich B, Blaser K, Scheynius A, Crameri R.(PubMed)
(457) Manganese accumulation in bone following chronic exposure in rats: steady-state concentration and half-life in bone by O'Neal SL1, Hong L1, Fu S1, Jiang W1, Jones A1, Nie LH1, Zheng W2.(PubMed)
(458) A compact DD neutron generator-based NAA system to quantify manganese (Mn) in bone in vivo by Liu Y1, Byrne P, Wang H, Koltick D, Zheng W, Nie LH.(PubMed)
(459) Role of metal cofactors in enzyme regulation. Differences in the regulatory properties of the Escherichia coli nicotinamide adenine dinucleotide phosphate specific malic enzyme, depending on whether magnesium ion or manganese ion serves as divalent cation by Brown DA, Cook RA.(PubMed)
(450) Antioxidants and NOS inhibitors selectively targets manganese-induced cell volume via Na-K-Cl cotransporter-1 in astrocytes by Alahmari KA1, Harini P2, Prabhakaran K3, Chandramoorthy HC4, Ramakrishnan R5.(PubMed)
(451) Antioxidant effect of manganese by Coassin M1, Ursini F, Bindoli A.(PubMed)
(452) Manganese supplementation protects against diet-induced diabetes in wild type mice by enhancing insulin secretion by Lee SH1, Jouihan HA, Cooksey RC, Jones D, Kim HJ, Winge DR, McClain DA.(PubMed)
(453) Manganese-Mediated MRI Signals Correlate With Functional β-Cell Mass During Diabetes Progression by Meyer A1, Stolz K1, Dreher W2, Bergemann J1, Holebasavanahalli Thimmashetty V2, Lueschen N1, Azizi Z1, Khobragade V1, Maedler K3, Kuestermann E2.(PubMed)
(454) Essential elements in depression and anxiety. Part II by Młyniec K1, Gaweł M2, Doboszewska U3, Starowicz G4, Pytka K5, Davies CL6, Budziszewska B7.(PubMed)
(455) Effect of antioxidant mineral elements supplementation in the treatment of hypertension in albino rats by Muhammad SA1, Bilbis LS, Saidu Y, Adamu Y.(PubMed)
(456) Manganese supplementation reduces the blood cholesterol levels in Ca-deficient ovariectomized rats by Bae YJ1, Choi MK, Kim MH.(PubMed)
(457) BOVINE INFERTILITY--RESPONSE TO MANGANESE THERAPY by WILSON JG.(PubMed)
(458)Pharmaceutical effect of manganese porphyrins on manganese superoxide dismutase deficient mice by Hayakawa N1, Asayama S, Noda Y, Shimizu T, Kawakami H.(PubMed)
(459) Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease by Dumont M1, Wille E, Stack C, Calingasan NY, Beal MF, Lin MT.(PubMed)
(460) Nutritional immunity beyond iron: a role for manganese and zinc by Kehl-Fie TE1, Skaar EP.(PubMed)
(461) Genetic factors and manganese-induced neurotoxicity. by Chen P1, Parmalee N1, Aschner M1.(PubMed)
(462) Manganese neurotoxicity: a focus on glutamate transporters by Karki P, Lee E, Aschner M1.(PubMed)
(463) HEMOGLOBIN PRODUCTION IN ANEMIA LIMITED BY LOW PROTEIN INTAKE : INFLUENCE OF IRON INTAKE, PROTEIN SUPPLEMENTS AND FASTING by Hahn PF1, Whipple GH.(PubMed)
(464) Effect of iron deficiency anemia on the levels of hemoglobin A1c in nondiabetic patients by Coban E1, Ozdogan M, Timuragaoglu A.(PubMed)
(465) Low serum levels of zinc, copper, and iron as risk factors for osteoporosis: a meta-analysis by Zheng J1, Mao X, Ling J, He Q, Quan J.(PubMed)
(466) Brain iron deficiency and excess; cognitive impairment and neurodegeneration with involvement of striatum and hippocampus by Youdim MB1.(PubMed)
(467) Athletic induced iron deficiency: new insights into the role of inflammation, cytokines and hormones by Peeling P1, Dawson B, Goodman C, Landers G, Trinder D.(PubMed)
(468) Aggett PJ. Iron. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:506-20.
(469) Murray-Kolbe LE, Beard J. Iron. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:432-8.
(470) Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function by Lakhal-Littleton S1, Wolna M2, Carr CA2, Miller JJ2, Christian HC2, Ball V2, Santos A3, Diaz R3, Biggs D3, Stillion R4, Holdship P5, Larner F5, Tyler DJ2, Clarke K2, Davies B3, Robbins PA2.(PubMed)
(471) Effect of dietary iron loading on recognition memory in growing rats by Han M1, Kim J1.(PubMed)
(472) [Anaemia and iron deficiency in clinical practice:from cardiology to gastroenterology and beyond].
(474) Essential elements in depression and anxiety. Part I by Młyniec K1, Davies CL2, de Agüero Sánchez IG3, Pytka K4, Budziszewska B5, Nowak G6.(PubMed)
(475) Iron deficiency: an emerging therapeutic target in heart failure by Cohen-Solal A1, Leclercq C2, Deray G3, Lasocki S4, Zambrowski JJ5, Mebazaa A6, de Groote P7, Damy T8, Galinier M9.(PubMed)
(476) Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood by Walter T1.(PubMed)
(479) Effects of anemia and iron deficiency on quality of life in women with heavy menstrual bleeding by Peuranpää P1, Heliövaara-Peippo S, Fraser I, Paavonen J, Hurskainen R.(PubMed)
(480) Iron deficiency and fatigue in adolescent females with heavy menstrual bleeding by Wang W1, Bourgeois T, Klima J, Berlan ED, Fischer AN, O'Brien SH.(PubMed)
(481) Iron at the interface of immunity and infection by Nairz M1, Haschka D1, Demetz E1, Weiss G1.(PubMed)
(482) Impact of iron deficiency anemia on cell-mediated and humoral immunity in children: A case control study by Das I1, Saha K1, Mukhopadhyay D2, Roy S1, Raychaudhuri G3, Chatterjee M2, Mitra PK1.(PubMed)
(483) Iron Supplementation Attenuates the Inflammatory Status of Anemic Piglets by Regulating Hepcidin by Pu Y1, Guo B, Liu D, Xiong H, Wang Y, Du H.(PubMed)
(484) A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia by Guida C1, Altamura S2, Klein FA3, Galy B3, Boutros M4, Ulmer AJ5, Hentze MW6, Muckenthaler MU2.(PubMed)
(485) Prediction of iron deficiency in chronic inflammatory rheumatic disease anaemia by Baumann Kurer S1, Seifert B, Michel B, Ruegg R, Fehr J.(PubMed)
(486) Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron by Toblli JE1, Di Gennaro F2, Rivas C2.(PubMed)
(487) Antimicrobial copper's potential.[No authors listed](PubMed)
(488) Effects of in-feed copper and tylosin supplementations on copper and antimicrobial resistance in fecal enterococci of feedlot cattle by Amachawadi RG1, Scott HM, Aperce C, Vinasco J, Drouillard JS, Nagaraja TG.(PubMed)
(489) Copper and immunity by Percival SS1.(PubMed)
(490) The immune system as a physiological indicator of marginal copper status? by Bonham M1, O'Connor JM, Hannigan BM, Strain JJ.(PubMed)
(491) Molecular basis for antioxidant enzymes in mediating copper detoxification in the nematode Caenorhabditis elegans by Song S1, Zhang X1, Wu H1, Han Y2, Zhang J1, Ma E1, Guo Y2.(PubMed)
(492) The effects of coadministration of dietary copper and zinc supplements on atherosclerosis, antioxidant enzymes and indices of lipid peroxidation in the cholesterol-fed rabbit by Alissa EM1, Bahijri SM, Lamb DJ, Ferns GA.(PubMed)
(493) Is copper pro- or anti-inflammatory? A reconciling view and a novel approach for the use of copper in the control of inflammation by Berthon G1(PubMed)
(494) Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis by Yassin NZ1, El-Shenawy SM1, Abdel-Rahman RF1, Yakoot M2, Hassan M3, Helmy S4.(PubMed)
(495) Enhanced analgesic properties and reduced ulcerogenic effect of a mononuclear copper(II) complex with fenoprofen in comparison to the parent drug: promising insights in the treatment of chronic inflammatory diseases by Agotegaray M1, Gumilar F2, Boeris M3, Toso R3, Minetti A2.(PubMed)
(496) Nutraceuticals of anti-inflammatory activity as complementary therapy for rheumatoid arthritis by Al-Okbi SY1.(PubMed)
(497) Copper homeostasis in the CNS: a novel link between the NMDA receptor and copper homeostasis in the hippocampus by Schlief ML1, Gitlin JD.(PubMed)
(498) Effect of sex hormones on copper, zinc, iron nutritional status and hepatic lipid peroxidation in rats by Wachnik A1, Biró G, Biró L, Korom M, Gergely A, Antal M.(PubMed)
(499) Copper-zinc superoxide dismutase deficiency impairs sperm motility and in vivo fertility by Garratt M1, Bathgate R, de Graaf SP, Brooks RC.(PubMed)
(500) Iron and copper in male reproduction: a double-edged sword by Tvrda E1, Peer R, Sikka SC, Agarwal A.(PubMed)
(501) Interactions of peptide amidation and copper: novel biomarkers and mechanisms of neural dysfunction by Bousquet-Moore D1, Prohaska JR, Nillni EA, Czyzyk T, Wetsel WC, Mains RE, Eipper BA.(PubMed)
(502) Deficient copper concentrations in dried-defatted hepatic tissue from ob/ob mice: A potential model for study of defective copper regulation in metabolic liver disease by Church SJ1, Begley P1, Kureishy N1, McHarg S1, Bishop PN1, Bechtold DA2, Unwin RD3, Cooper GJ4.(PubMed)
(503) Update on anemia and neutropenia in copper deficiency by Lazarchick J1.(PubMed)