Monday, 4 November 2013

Phytochemicals in Foods - 9 Health Benefits of Lariciresinol

Lariciresinol is a phytochemical in the class of Lignans (phytoestrogens), found abundantly in sesame seed, brassica vegetables, etc.

Health Benefits
1. Mammary tumor growth and reduces blood vessel density
In the investigation of the effects and possible mechanisms of action of lariciresinol on hormone responsive mammary cancer in vivo in dimethylbenz[a]anthracene induced mammary cancer in rats, and in human MCF-7 breast cancer xenografts in athymic mice, found that both models, lariciresinol administration inhibited the tumor growth and tumor angiogenesis. In MCF-7 cells, enterolactone significantly inhibited the E2-stimulated VEGF secretion. Moreover, in MCF-7 xenografts, lariciresinol administration enhanced tumor cell apoptosis and increased estrogen receptor beta expression. Lariciresinol and its further metabolites secoisolariciresinol, enterodiol and enterolactone were found in serum of both rats and athymic mice confirming a similar lignan metabolism pattern as in humans, according to "Dietary lariciresinol attenuates mammary tumor growth and reduces blood vessel density in human MCF-7 breast cancer xenografts and carcinogen-induced mammary tumors in rats" by
Saarinen NM, Wärri A, Dings RP, Airio M, Smeds AI, Mäkelä S.(1)

2. Vascular inflammation and endothelial dysfunction
In the investigation of whether dietary intake of plant lignans in a free-living population was associated with markers of vascular inflammation and function, found that Higher MAT intakes in the context of a typical Northern Italian diet are associated to lower vascular inflammation and endothelial dysfunction, which could have some implications in CVD prevention, according to "Intake of the plant lignans matairesinol, secoisolariciresinol, pinoresinol, and lariciresinol in relation to vascular inflammation and endothelial dysfunction in middle age-elderly men and post-menopausal women living in Northern Italy" by Pellegrini N, Valtueña S, Ardigò D, Brighenti F, Franzini L, Del Rio D, Scazzina F, Piatti PM, Zavaroni I.(2)

3. Breast cancer
In the investigation of a usual dietary intakes of total and specific lignans with tumor characteristics in 683 women with breast cancer and 611 healthy women without breast cancer enrolled in the Data Bank and BioRepository at Roswell Park Cancer Institute (RPCI),
found that significant differences in the contribution to these effects by specific lignans, especially matairesinol and lariciresinol. In summary, in this case-control study of dietary lignan intakes and breast cancer, we found that higher lignan intakes were associated with lower risks of breast cancer with more favorable prognostic characteristics. Future investigations are warranted to explore the strong associations observed with ER(-) cancer in premenopausal women, according to "Dietary intakes of total and specific lignans are associated with clinical breast tumor characteristics" by McCann SE, Hootman KC, Weaver AM, Thompson LU, Morrison C, Hwang H, Edge SB, Ambrosone CB, Horvath PJ, Kulkarni SA.(3)

4. Ovarian cancer
In the determination of the impact of phytoestrogen consumption on breast cancer risk, its role on ovarian cancer in a total of 205 cases and 390 controls were included in analyses. Unconditional logistic regression analyses were conducted to examine associations with total phytoestrogens, as well as isoflavones (daidzein, genistein, formononetin, and glycitein), lignans (matairesinol, lariciresinol, pinoresinol, secoisolariciresinol), and coumestrol, found that phytoestrogen consumption may decrease ovarian cancer risk, although results did not reach statistical significance, according to "Phytoestrogen consumption from foods and supplements and epithelial ovarian cancer risk: a population-based case control study" by Bandera EV, King M, Chandran U, Paddock LE, Rodriguez-Rodriguez L, Olson SH.(4)

5. Antifungal activity
In the investigation of the effect of Lariciresinol is an enterolignan precursor isolated from the herb Sambucus williamsii, a folk medicinal plant used for its therapeutic properties against antifungal properties and mode of action, found that lariciresinol was associated with lipid bilayers and induced membrane permeabilization. Therefore, the present study suggests that lariciresinol possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans, according to "Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans" by Hwang B, Cho J, Hwang IS, Jin HG, Woo ER, Lee DG.(5)

6. Antioxidants
In the investigations of Taxus baccata L. by successive chromatographic methods resulted in the isolation of the lignans lariciresinol (1), taxiresinol (2), 3'-demethylisolariciresinol-9'-hydroxyisopropylether (3), isolariciresinol (4), and 3-demethylisolariciresinol (5) as well as taxoids. Compounds 1-5 were evaluated for their acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and lipoxygenase (LOX) inhibitory activities, found that the compounds displayed a great scavenging activity against DPPH especially at 500 and 1000 microg ml(-1). Besides, they were found to exert noteworthy reducing antioxidant power on ferric ions. In particular, the FRAP of compounds 2 (3.552 +/- 0.02), 4 (3.021 +/- 0.71), and 5 (3.533 +/- 0.01) were as high as that of the reference chlorogenic acid (3.618 +/- 0.01) at 1000 microg ml(-1). None of the compounds exhibited chelating ability against ferrous ions, according to "Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L" by Kucukboyaci N, Orhan I, Sener B, Nawaz SA, Choudhary MI.(6)

7. CHD, CVD, cancer, and all cause mortality
In the investigation of whether the intakes of 4 plant lignans (lariciresinol, pinoresinol, secoisolariciresinol, and matairesinol) were inversely associated with coronary heart disease (CHD), cardiovascular diseases (CVD), cancer, and all-cause mortality.
found that total lignan intake was not associated with mortality. The intake of matairesinol was inversely associated with mortality due to CHD, CVD, cancer, and all causes. We cannot exclude the possibility that the inverse association between matairesinol intake and mortality is due to an associated factor, such as wine consumption, according to "Intakes of 4 dietary lignans and cause-specific and all-cause mortality in the Zutphen Elderly Study" by
Milder IE, Feskens EJ, Arts IC, Bueno-de-Mesquita HB, Hollman PC, Kromhout D.(7)

8. Anti-ulcerogenic effects
In the investigation of four lignan type compounds, lariciresinol, taxiresinol, isolariciresinol and 3-demethyl-iso-lariciresinol isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques, indicated that all compounds were shown to possess significant anti-ulcerogenic activity at both doses. However, the effect of taxiresinol was the most prominent, according to "Anti-ulcerogenic lignans from Taxus baccata L" by Gurbuz I, Erdemoglu N, Yesilada E, Sener B.(8)

9. Lipid peroxidation
In the study of the aqueous methanol extracts isolation, 1',2',3',4'-tetrahydro-5'-deoxy-pinnatanine (1), pinnatanine (2), roseoside (3), phlomuroside (4), lariciresinol (5), adenosine (6), quercetin 3-O-beta-D-glucoside (7), quercetin 3,7-O-beta-D-diglucopyranoside (8), quercetin 3-O-alpha-L-rhamnopyransol-(1-->6)-beta-D-glucopyranosol-7-O-beta-D-glucopyranoside (9), isorhamnetin-3-O-beta-D-6'-acetylglucopyranoside (10) and isorhamnetin-3-O-beta D-6'-acetylgalactopyranoside (11) from thefresh Hemerocallis fulva leaves,
found that compounds 3-5 and 7-11 were found to possess strong antioxidant properties, inhibiting lipid oxidation by 86.4, 72.7, 90.1, 79.7, 82.4, 89.3, 82.2, and 93.2%, respectively at 50 microg/mL. Compound 1 is novel and compounds 3-6 and 8-11 described here in are isolated for the first time from daylily leaves, according to "Lipid peroxidation inhibitory compounds from daylily (Hemerocallis fulva) leaves" by Zhang Y, Cichewicz RH, Nair MG.(9)

10. Etc.

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