Friday, 22 November 2013

Phytochemicals and Impotence

 With either mental or physical stimulation, your brain signals the nerve ending in the penis to release nitric oxide. Nitric oxide relaxes or dilates blood vessels, enabling them to open up and bring more blood to the penis and helping to create an erection. Impotence is defined as a condition of the inability of men to sustain an erection for sexual activity.

Types of food to prevent and treat impotence
1. Tomato
In the study to examine whether lycopene could lower oxidative stress and attenuate ED in diabetic rats with administration of Lycopene (10, 30, 60 mg/kg/d) via intragastric intubation for 8 weeks to streptozotocin (STZ) (50 mg/kg, i.v.) induced diabetic rats, showed that chronic lycopene treatment significantly and dose dependently restored ED in diabetic rats by lowering blood glucose, reducing oxidative stress and up-regulating eNOS expression(1).

2. Chamomille Tea
According to the study of Antioxidant treatment with quercetin ameliorates erectile dysfunction in streptozotocin-induced diabetic rats at the Fourth Military Medical University, found that Treatment with 20 and 50mg/kg quercetin improved SOD activity, NOx and TBARS levels in corpus cavernosum of diabetic rats. Decreased expression of eNOS in diabetic rats was only ameliorated by 50mg/kg quercetin treatment. Quercetin could ameliorate ED in diabetic rats by inhibiting oxidative stress(2).

3. Cereals ready-to-eat
In the study to elucidate the role of oxidative stress in erectile dysfunction associated with aging and to investigate the effect of treatment with vitamin E in this respect, showed that antioxidant therapy with vitamin E ameliorates the age-associated erectile dysfunction. Sildenafil may exert some antioxidant properties which add to the advantages of its long-term use. The effect of combinations of low-dose sildenafil and vitamin E on age-associated erectile dysfunction merits to be studied(3)

4. Pomegranate juice (PJ)
In the study to examine the effect of long-term PJ intake on intracavernous blood flow and penile erection  in the rabbit model, indicated that On spectrophotometric analysis PJ showed the highest capacity to decrease low density lipoprotein oxidation and inhibit cellular oxidative stress in macrophages. The rabbit model of arteriogenic ED demonstrated decreased intracavernous blood flow, erectile dysfunction, loss of smooth muscle relaxation, decreased endothelial NOS and neuronal NOS, increased inducible NOS expression, diffused cavernous fibrosis and increased cavernous levels of the oxidative product isoprostane 8-epi-prostaglandin F2alpha. Long-term PJ intake increased intracavernous blood flow, improved erectile response and smooth muscle relaxation in ED and control groups while having no significant effect on NOS expression. PJ intake prevented erectile tissue fibrosis in the ED group(4).

5. Mediterranean diet

 In the study to test the effect of a Mediterranean-style diet on ED in men with the metabolic syndrome in Sixty-five men with the metabolic syndrome met the inclusion/exclusion criteria; 35 out of them were assigned to the Mediterranean-style diet and 30 to the control diet, showed that after 2 years, men on the Mediterranean diet consumed more fruits, vegetables, nuts, whole grain, and olive oil as compared with men on the control diet. Endothelial function score and inflammatory markers (C-reactive protein) improved in the intervention group, but remained stable in the control group. There were 13 men in the intervention group and two in the control group (P=0.015) that reported an IIEF score of 22 or higher. Mediterranean-style diet rich in whole grain, fruits, vegetables, legumes, walnut, and olive oil might be effective per se in reducing the prevalence of ED in men with the metabolic syndrome(5).

6. Etc.

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Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/22530309
(2) http://www.ncbi.nlm.nih.gov/pubmed/21664865
(3) http://www.ncbi.nlm.nih.gov/pubmed/22280834 
(4) http://www.ncbi.nlm.nih.gov/pubmed/15947695  
(5) http://www.ncbi.nlm.nih.gov/pubmed/16395320

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