Infertility is defined as inability of a couple to conceive after 12
months of unprotected sexual intercourse or can not carry the pregnancy
to term. It effects over 5 millions couple alone in the U. S. and many
times more in the world. Because of unawareness of treatments, only 10%
seeks help from professional specialist. the unexplained causes of
infertility is defined as if the woman and men reproductive system are
function normally but the present-day medical technology and medical doctors can not give a reason
why the couple can not conceive. What is male infertility sperm-ubiquitin tag immunoassay (SUTI)??
I. Definition
The test is to detect the inherited fertility disorder of the infertile male to avoid any unnecessary
fertility treatments for women.
II. Procedure
The
semen sperm is taken from the infertile male in the clinic laboratory
and the surface of sperm is screened for ubiquintin which is a small,
highly-conserved regulatory protein that is ubiquitously expressed in
complex structures enclosed within membranes.
III. Diagnosis
Since
ubiquitnin is considered a universal marker of semen abnormalities,
including sperm head and tail defects and semen contaminants such as
spermatids, leukocytes and cellular debris.
The semen example is
screened through immunofluorescence and flow cytometry, if there is an
displays of increasing binding of anti-ubiquitin antibodies to sperm
surface, the sample sperm is considered abnormality which increases the
risk of infertility becasues elevated sperm ubiquitin levels have been
associated with reduced fertility or infertility.
This test is
still in developed state, if proven success, it not only helps to avoid
many unnecessary treatments for unfertile couple but also helps to
remove damaged sperm from semen sample before IVF and ICSC.
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