Conventional medicine plays an important role and most of the time is
the first treatment for a couple who for what ever reason cam not
conceive after 1 year of unprotected sexual intercourse or can not carry
the pregnancy to full term. Immune system plays an important role in
protect our body against forming of free radicals and bacteria and
virus, but for what ever reasons, sometime the immune system attack
sperm in the women reproductive organs or sperm in the testes in men,
leading to infertility In this article, we will discuss how immune
dysfunction affects fertility in conventional perspective.
1. Definition
Immune
system helps to recognize the foreign invasion such as forming of free
radicals, bacteria and virus and destroy them. For some reasons, Some
women and men's immune system become abnormal, leading the immune system
to attach it's own body tissues or view the sperm as foreign invasion.
2. Types of immune dysfunction effecting infertility
a) Anti-phospholipid antibody syndrome
Antiphospholipid
syndrome is defined as a condition which causes blood clotting in the
arteries or veins and various other problems. It also causes abnormal
production of antibody which attached not only the body invader but also
it' s body tissues including sperm in the test, leading to low quality
of sperm.
As of today, there is still no cure for the above syndrome,
but some convention medication can help to control it, thereby reducing
the risk of blood clotting and infertility.
b) Antinuclear antibody (ANA)
Antinuclear
antibodies are as specific class of auto antibodies which have the
ability to attack structures in the nucleus of cells instead of
performing the normal antibody function. Since the nucleus of a cell
contains genetic material referred to as DNA (deoxyribonucleic acid),
ANA (antinuclear antibody) test can be performed on a patient's blood
sample as part of the diagnostic process to detect certain autoimmune
diseases caused by above.
c) Antithyroid antibodies
Antithyroid
antibodies can be tested by diagnosing the patient thyroid hormone and
the thyroid stimulating hormone TSH in the blood sample. Only
hypothyroidism causes auto immune dysfunction. They are defined as
abnormal function of antibodies produced by immune system act directly
against the thyroid gland. It may be caused by inflammation of the
thyroid gland leading to abnormal production of certain antithyroid
antibodies such as antithyroglobulin and antimicrosomal that cause
miscarriage by attacking the placental or fetal tissues.
d) Anti-sperm antibody
Antisperm
antibody can be produced by either partner. It is defined as a certain
class of protein attaching themselves to the sperm, causing other cells
in the immune system to attack them, leading to low quality sperm in men
and effecting the ability of sperm to fertilize the egg in women.
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