Gout
Gout mostly effected one joint is defined as a acute
and recurrent condition of arthritis as a result of uric acid builds up
in blood cause of joint inflammation.
hytochemicals to prevent Gout
1. Quercetin and Rutin
Dr. Zhu JX and research team at the School of Life Sciences, Nanjing University found that the effects of quercetin
and rutin on serum urate levels in hyperuricemic mice induced by
oxonate and the inhibition of enzyme activities in mouse liver are
discussed in relation to their absorption and metabolism, and their
potential application to treat gout and hyperuricemia(15).
2. Morin
Morin (3,5,7,2',4'-pentahydroxyflavone) a phytochemical found in the
twigs of Morus alba L. documented in traditional Chinese medicinal
literature to treat conditions akin to gout,
was demonstrated to exert potent inhibitory action on urate uptake in
rat renal brush-border membrane vesicles, indicating that this compound
acts on the kidney to inhibit urate reabsorption(16).
3. Other phytichemicals
In the study of 15 flavonoids (quercetin, morin, myricetin,
kaempferol, icariin, apigenin, luteolin, baicalin, silibinin,
naringenin, formonoetin, genistein, puerarin, daidzin and naringin
dihydrochalcone) selected to investigate for their hypouricemic action
in mice, found that Oral administration of quercetin, morin, myricetin,
kaempferol, apigenin and puerarin at 50 and 100 mg/kg for 3 d was able
to elicit hypouricemic actions in hyperuricemic mice induced by
potassium oxonate. Luteolin, formonoetin and naringenin showed the
significant effects only at 100 mg/kg. Quercetin, puerarin, myricetin, morin and kaempferol significantly reduced liver uric acid level in hyperuricemic animals. In addition, quercetin, morin, myricetin, kaempferol and puerarin exhibited significant inhibition on the liver xanthine oxidase (XOD) activities(17).
4. Etc.
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Sources
(15) http://www.ncbi.nlm.nih.gov/pubmed/15182918
(16) http://www.ncbi.nlm.nih.gov/pubmed/16169936
(17) http://www.ncbi.nlm.nih.gov/pubmed/17666819
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