Saturday, 23 November 2013

Migraine with aura - The Medical conditions associated with

Migraine with Aura defined as condition of common migraine, involves migraine headaches that are preceded by some sort of visual disturbance of an aura such as difficulty speaking, vertigo, ringing in ears, or a number of other brainstem-related symptoms, but sometimes it may be associated with underlying hereditary or acquired cerebrovascular disorders, according to " Migraine aura pathophysiology: the role of blood vessels and microembolisation"
Dalkara T, Nozari A, Moskowitz MA.(1)
IV. Medical conditions associated with Migraine with aura
Reduction of cardiovascular risk factors, smoking cessation and use of non-estrogen-containing oral contraceptives in female patients are beneficial strategies to reduce the risk of ischaemic events in patients with migraine (especially those with aura). Attack frequency, acute medication overuse, obesity and coexisting depression and anxiety disorders are particularly strong but potentially modifiable independent risk factors for progression to chronic migraine

1. Oxidative stress
Oxidative stress are associated with increased risk of migraine metabolic risk such as nitrosative stress, an atherogenic lipid profile and hyperinsulinemia(V.1)

2. Obesity
In the study of One hundred and twenty-four patients (77 female, 36 with aura; mean age 12.9 +/- 2.8 years; age range 4.0-17.0 years) conducted by Baskent University, the percentage of obesity was 17.7. Although pain severity and duration were not different among groups, obese patients had more frequent attacks than the overweight and normal weight patients (5.3 +/- 2.4, 4.4 +/- 2.4 and 3.8 +/- 2.4 attacks/month, respectively, P = 0.018)(V.2)

3. Depression and anxiety disorders
Depression and anxiety disorders obese migraineurs. The relationship of obesity with migraine frequency and migraine-related disability is modified by depression and by anxiety, with the strongest effect observed in migraineurs with both depression and anxiety.(V.3)

4. Cerebellar Brain Infarctions
Cerebellar Brain Infarctions refers to to the death of brain cells which control cognitive functions as a result of a local lack of oxygen due to obstruction of the tissue's blood supply. In the article of "Migraine with Aura in Women Is Associated with Cerebellar Brain Infarction", Dr. S. Andrew Josephson, MD wrote"Infarcts were significantly more commonly found in women with migraine with aura than in those women without headache (31% vs. 25%; p=.04), but no significant differences were seen in men; this difference in women persisted after adjustments for age, sex, and follow-up time. Cerebellar infarctions, but not those in the cortical or subcortical regions, were significantly more common in women with migraine with aura compared with those without headache. No significant differences were seen in cerebellar infarcts among men. Migraine without aura and non-migraine headache were not associated with any increased risk of infarction"(V.4)

5. Stroke
migraine with aura headache can increase the risk of ischemic stroke in women of childbearing age, according to "Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age" by Donaghy M, Chang CL, Poulter N; European Collaborators of The World Health Organisation Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception.(V.5)

6. Epilepsy
There is a link associated between headache/migraine and epilepsy by using the PubMed data base, according to "Links between headaches and epilepsy: current knowledge and terminology.[Article in English, Spanish]" by Caminero A, Manso-Calderón R.(V.6)

7. Vascular diseases

Some researchers suggested that women who use hormonal contraceptives and hormone replacement treatment may increase the risk of migraine occurrence and administration of exogenous hormones may cause worsening of migraine as may expose migrainous women to an increased risk of vascular disease(V.7)

8. Etc.

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