Fibromyalgia, according to the American College of
Rheumatology 1990 Criteria for the Classification of Fibromyalgia in the
newly proposed criteria for the classification of fibromyalgia are 1)
widespread pain in combination with 2) tenderness at 11 or more of the
18 specific tender point sites(a) as a result in responding to pressure.
1. Vitamin D
Vitamin D deficiency is associated with anxiety and depression in
fibromyalgia. In a study of Seventy-five Caucasian patients who
fulfilled the ACR criteria for fibromyalgia had serum vitamin D levels
measured and completed the Fibromyalgia Impact Questionnaire (FIQ) and
Hospital Anxiety and Depression showed that Vitamin D deficiency is
common in fibromyalgia and occurs more frequently in patients with
anxiety and depression. The nature and direction of the causal
relationship remains unclear, but there are definite implications for
long-term bone health(23).
2. Omega 3 fatty acid
In the study to investigate and report on patients with neuropathic pain
who responded to treatment with omega-3 fatty acids, five patients with
different underlying diagnoses including cervical radiculopathy,
thoracic outlet syndrome, fibromyalgia, carpal tunnel syndrome, burn
injury were treated with high oral doses of omega 3 fish oil (varying
from 2400-7200 mg/day of EPA-DHA), found thatthese patients had
clinically significant pain reduction, improved function as documented
with both subjective and objective outcome measures up to as much as 19
months after treatment initiation. No serious adverse effects were
reported(24).
3. Caffeine
In a study of forty-three of fifty-eight (74.1%) female patients with
fibromyalgia completed an eight-week treatment period testing the
combination of carisoprodol, paracetamol (acetaminophen) and caffeine
versus placebo, found that the combination of carisoprodol and
paracetamol (acetaminophen) and caffeine are effective in the treatment
of fibromyalgia(25).
4. Coenzyme Q10
CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy
number, decreased oxidative stress, and increased mitochondrial
biogenesis. The results suggest that CoQ10 could be an alternative
therapeutic approach for FM(26).
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/2306288
(23) http://www.ncbi.nlm.nih.gov/pubmed/16850115
(24) http://www.ncbi.nlm.nih.gov/pubmed/20090445
(25) http://www.ncbi.nlm.nih.gov/pubmed/2667860
(26) http://www.ncbi.nlm.nih.gov/pubmed/22898267
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