Tuesday, 26 November 2013

Duodenal ulcers : The Symptoms

Duodenal ulcers, a type of peptic ulcer is defined as a condition of a localized tissue erosion in the lining  the duodenum as a result of bacteria Helicobacter pylori (H pylori) in most cases. According to the study by Department of Research, University Hospital, Basel, fasting gastrin and pepsinogen-I and -II concentrations were significantly higher in H pylori positive compared with H pylori negative subjects. Neither age nor sex affected basal gastrin and pepsinogen concentrations in H pylori negative subjects. Fasting gastrin, pepsinogen-I and -II concentrations in serum samples were similar in H pylori positive persons with no symptoms and those with duodenal ulcers suggesting that similar mechanisms are involved in increasing plasma concentrations of these variables in both populations. Hypergastrinaemia and hyperpepsinogenaemia are therefore probably secondary to active H pylori infection(1).
A. Symptoms
1. Dyspepsia
Dyspepsia, may be the first symptom of peptic ulcer disease (an ulcer of the stomach or duodenum), is defined by persistence of pain, burning or discomfort localised to the upper abdomen; some authors include in dyspepsia symptoms such as belching, bloating, alitosis, nausea, postprandial repletion, vomiting and regurgitation, etc. as a result of the infection of Helicobacter pylori (Hp)(2).
2. Functional disorders
Functional disorders mainly occur in young, anxious hyperactive, sometimes obsessional patients and involve all parts of digestive tract: feeling of obstruction the upper oesophagus or dysphagia; aerophagia related to a slow gastric emptying or gastric fullness relieved by eructation. Although psychologic profiles have been associated with gastro-duodenal ulcer, these are not necessary for the development of the disease(3).
3. Loss of appetite
It may be result of slow gastric emptying.
4. Unexplained weight loss
It nay be cause by malnutrition due to  Upper gastrointestinal disorders.
6. Bloody stool (blood may be red, black)
The color of blood depends to the location of bleeding
7. Vomiting blood
As a result of upper gastrointestinal bleeding
8. Etc.
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(1) http://www.ncbi.nlm.nih.gov/pubmed/8314506
(2) http://www.ncbi.nlm.nih.gov/pubmed/10367546
(3) http://www.ncbi.nlm.nih.gov/pubmed/8281896

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