Friday, 6 March 2020

Omega 3 Fatty Acid Inhibits the Onset of Acute Steatohepatitis in Vivos

By Kyle J. Norton

Steatohepatitis is a fatty liver disease caused by inflammation of the liver tissue accompanied by fat accumulation.

A most common form of steatohepatitis is non-alcoholic steatohepatitis (NASH), an advanced form of non-alcoholic fatty liver disease (NAFLD) that is not caused by excessive alcohol drinking.

Most cases of NASH if untreated can lead to liver scars or building up of scar over time, a condition of liver cirrhosis and one of the most common causes of liver cancer.

Most people with non-inflammatory-alcoholic fatty liver disease are asymptomatic, however, the inflammation caused by non-alcoholic steatohepatitis may induce liver damage, leading to a reduced function of the liver that orchestrates the onset of liver symptoms.

The most common symptoms are abdominal swelling, enlarged blood vessels just beneath the skin's surface, enlarged spleen, red palms, and jaundice.

People with steatohepatitis have been associated with the increased risk of liver failure and liver cancer, due to excessive formation of liver scar tissues, epidemiologically.

According to the statistics, fatty liver affects approximately 25% of the general population worldwide. Non-alcoholic steatohepatitis (NASH), is very common in overweight persons.

Researchers do not know the exact cause of steatohepatitis. However, they do know certain medical conditions such as diabetes, being overweight or obese and people with metabolic syndrome, including high blood cholesterol are some most prevalent risks of the disease.

Some researchers suggested that people who are viral hepatitis carriers are also at risk of steatohepatitis.

Omega-3 fatty acids are phytochemicals in the class of lipids, found abundantly in deepsea fisk, dark-green leafy vegetables, grains, legumes, nuts, etc.

The three main components of Omega-3 fatty acids are alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).

On finding a potential phytochemical for the treatment of liver diseases, researchers examined the ω-3-acid ethyl ester prescription Lovaza effects on acute steatohepatitis.

According to the results of the study,
* In vivo, administration of CMPF to mice before or after high-fat diet feeding at exposures equivalent to those observed in humans increased whole-body lipid metabolism, improved insulin sensitivity, increased beta-oxidation, reduced lipogenic gene expression, and ameliorated steatosis.

* CMPF acutely inhibits Acetyl-CoA Carboxylase (Acc) activity in the monitoring of liver enzymatic activity and induces long-term loss of SREBP1c and ACC1/2 expression in lipid metabolism.

* CMPF upregulated the expression of FGF21, which is required for long-term steatosis protection.

Moreover, researchers said, "MPF treatment in mice parallels the effects of human Lovaza™ supplementation, revealing that CMPF may contribute to the improved metabolic effects observed with ω-3 fatty acid prescriptions".

Taken altogether, Omega-3 fatty acids may be considered a functional food for the prevention and treatment of acute steatohepatitis, pending to the confirmation of the larger sample size and multicenter human study.

Intake of Omega-3 fatty acids in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis by Prentice KJ1, Wendell SG2, Liu Y1, Eversley JA1, Salvatore SR2, Mohan H1, Brandt SL1, Adams AC3, Serena Wang X1, Wei D1, FitzGerald GA4, Durham TB3, Hammond CD3, Sloop KW3, Skarke C5, Schopfer FJ6, Wheeler MB. (PubMed)

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