Tuesday, 3 March 2020

Cranberry, the Anti-Alzheimer's disease Functional Remedy

By Kyle J. Norton

Dementia is a neuropsychiatric disorder as a result of cognitive impairment and behavioral disturbances. The behavioral and psychological symptoms of dementia (BPSD) are common, contributing to caregiver burden and premature institutionalization.

About 5-8% of all people over the age of 65 have some forms of dementia, and this number doubles every five years above that age.

Dementia is the loss of mental ability that is severe enough to interfere with people's every life.

Alzheimer's disease (AD) is a neurodegenerative disease occurred mostly in the older population characterized by progressive brain cell death that happens over time.

Alzheimer's disease worsens over time and it is fatal.

American typical diet contains a high amount of saturated and trans fat, artificial ingredients with fewer fruits and vegetable which can lead to dementia and other kinds of diseases.

As the disease progression, the brain tissue of the patient with AD has fewer and fewer nerve cells and connections.

In the elderly, age-related to the changes in the brain include atrophy (shrinking) of certain parts of the brain, inflammation associated with overexpression of free radicals in the induction of neuro cytotoxicity that affects the energy production within cells and long-term accumulated of plaques in the neurons caused by unhealthy diet are many prevalent risk factors that elevate the early onset and progression of the disease.

In free radical theory, free radical overexpression causes the reduced levels of antioxidant enzymes produced by the elderly initiates the onset of oxidative stress that may attack and damage lipids, proteins, and DNA, leading to irreversible brain cells damage and development of AD.

β-amyloid (Aβ) accumulated in the neurons, the main component of the amyloid plaques in the brains have been found in patients with Alzheimer's disease.

Cranberry is an evergreen dwarf shrub, genus Vaccinium, belongings to the family Ericaceae, native to Northern America and Southern Asia. Because of its health benefits, cranberry has been cultivated in some parts of the world for commercial profit and used in traditional and herbal medicine to treat wounds, urinary disorders, diarrhea, diabetes, stomach ailments, and liver problems.

On finding a potential compound for the treatment of dementia, researchers investigated the cranberry extract (CBE) rich in polyphenols that delay paralysis induced by alleviating β-amyloid (Aβ) toxicity Alzheimer's disease (AD) in C. elegans model.

According to the experimental results, researchers suggested that CBE showed a strong anti-AD activity by inhibiting the level of Aβ toxicity and promoting memory health, the two major pathological parameters in AD.

C. elegans AD model treated with CBE exerted significantly preventive and therapeutic protocols.

Based on the findings, researchers said, "CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals".

Taken altogether, cranberry may be considered a remedy for the management of AD, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease by Guo H1, Dong YQ2, Ye BP. (PubMed)

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