Myocardial ischemia injury is a medical condition caused by severe impairment of coronary blood supply, leading to damage or dysfunction of the heart tissue.
Myocardial reperfusion is the process which restores the coronary blood flow after a period of coronary blockage, causing a severely reduced or no oxygen blood flow to the heart.
The condition severity is totally dependent on the intensity and duration of the coronary occlusion.
Myocardial ischemia injury is considered a “silent” and goes undetected, causing a catastrophic event associated with hemodynamic deterioration and sudden death
According to the statistics from the WHO, in 2008, 12% of all death or approximately 7,254,000 deaths worldwide have directly or indirectly caused by myocardial ischemia injury.
In other words, coronary heart disease causes 1/4 total death in the worldwide population and 50% of the death of heart disease.
Most common symptoms of myocardial ischemia injury are neck or jaw pain, shoulder or arm pain, a fast heartbeat, shortness of breath, and fatigue accompanied by nausea and vomiting.
Most common causes of myocardial ischemia injury are a result of the plaque built-up on the coronary arterial wall due to long-term unhealthy diet with higher amount of fat and trans fat, red meat, processed food and fewer in fruits and vegetables.
According to the statistics from the WHO, in 2008, 12% of all death or approximately 7,254,000 deaths worldwide have directly or indirectly caused by myocardial ischemia injury.
In other words, coronary heart disease causes 1/4 total death in the worldwide population and 50% of the death of heart disease.
Most common symptoms of myocardial ischemia injury are neck or jaw pain, shoulder or arm pain, a fast heartbeat, shortness of breath, and fatigue accompanied by nausea and vomiting.
Most common causes of myocardial ischemia injury are a result of the plaque built-up on the coronary arterial wall due to long-term unhealthy diet with higher amount of fat and trans fat, red meat, processed food and fewer in fruits and vegetables.
However, advanced age, male gender, genetic preposition and high level of plasma homocysteine are some prevalent factors found in patients with myocardial ischemia injury.
Most patients with CHD also are found to have a sedentary lifestyle.
Some researchers suggested, the promotion of a high-fat diet over the past few decades induced obesity may be the major culprit that celebrates the risk of myocardial ischemic injury.
Most patients with CHD also are found to have a sedentary lifestyle.
Some researchers suggested, the promotion of a high-fat diet over the past few decades induced obesity may be the major culprit that celebrates the risk of myocardial ischemic injury.
Dr. Meng F, the lead scientist wrote, "Obese patients are more sensitive to myocardial ischemia, which has been linked with high mortality rates".
And "(High fat diet-induced)An impaired MIF/AMPK activation response (cellular stress response) and consequent reduced membrane Glut4 expression (in the heart muscle) may play an important role in increasing myocardial susceptibility to I/R in obesity".
On finding a potent compound for the prevention of myocardial ischemia‑reperfusion injury (MIRI), researchers examined the effect of lycopene (LP), a type of carotenoid, that restores the cardioprotective on ischemic postconditioning (IPoC) in hypercholesterolemic rats.
The experimental male Wistar rats induced hypercholesterolemia by cholesterol‑enriched diet for 12 weeks that results in ischemia and reperfusion pretreatment with intraperitoneally for 5 consecutive days prior to ischemia and reperfusion.
According to the tested analysis, low‑dose LP in combination with IPoC ameliorated myocardial histopathological changes by reducing the infarct size and release of cardiac enzymes.
Furthermore, the combination also decreased cardiomyocyte apoptosis in hypercholesterolemic rats.
Additionally, parameters that cause neuronal cell dysfunction, induced neuron oxidative stress and apoptosis were also attenuated by LP and IPoC
And "(High fat diet-induced)An impaired MIF/AMPK activation response (cellular stress response) and consequent reduced membrane Glut4 expression (in the heart muscle) may play an important role in increasing myocardial susceptibility to I/R in obesity".
Lycopene is a phytochemical found in tomato in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and perform various functions in photosynthesis.
Furthermore, the combination also decreased cardiomyocyte apoptosis in hypercholesterolemic rats.
Believe it or not, comapred to the combination, no beneficial effects were found by the same dose of LP or IPoC treatment when they were used alone.
Based on the findings, researchers wrote, "LP can restore the cardioprotective effects of IPoC on MIRI in hypercholesterolemic rats".
Taken altogether, lycopene may be used for the prevention and treatment of myocardial ischemia injury, pending on the confirmation of the larger sample size and multicenter human study.
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Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene restores the effect of ischemic postconditioning on myocardialischemia‑reperfusion injury in hypercholesterolemic rats by Duan L1, Liang C1, Li X1, Huang Z1, Liu S1, Wu N2, Jia D. (PubMed)
(2) Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury by Tong C1,2,3, Peng C4, Wang L5, Zhang L6, Yang X7, Xu P8, Li J9, Delplancke T10,11, Zhang H12,13, Qi H. (PubMed)
(3) Myocardial Infarction by Niranjan Ojha, and Amit S. Dhamoon. (NCBI)
(4) Impaired myocardial MIF/AMPK activation aggravates myocardial ischemia reperfusion injury in high-fat diet-induced obesity by Meng F1, Li D2, Song B3, Li L. (PubMed)
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene restores the effect of ischemic postconditioning on myocardialischemia‑reperfusion injury in hypercholesterolemic rats by Duan L1, Liang C1, Li X1, Huang Z1, Liu S1, Wu N2, Jia D. (PubMed)
(2) Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury by Tong C1,2,3, Peng C4, Wang L5, Zhang L6, Yang X7, Xu P8, Li J9, Delplancke T10,11, Zhang H12,13, Qi H. (PubMed)
(3) Myocardial Infarction by Niranjan Ojha, and Amit S. Dhamoon. (NCBI)
(4) Impaired myocardial MIF/AMPK activation aggravates myocardial ischemia reperfusion injury in high-fat diet-induced obesity by Meng F1, Li D2, Song B3, Li L. (PubMed)
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