Saturday, 14 March 2020

Ficus religiosa L. (Moraceae) ot Sacred Fig Protects the Kidney Against Acute Renal Failure in Vivo

By Kyle J. Norton

Kidneys are to bean-shaped organs located below the rib cage, one on each side of your spine with a function to filter out blood and remove waste through urinary secretion.

The kidney also plays a critical in maintaining the levels of fluids in the body, by removing extra fluids to make urine.

Furthermore, the kidney also regulates electrolytes, blood pressure, maintains acid-base balance, produces hormone calcitriol, renin, and erythropoietin.

Kidney diseases are a class of medical conditions associated with reduced function of the kidney, in cases, complete loss of kidney function such as kidney failure.

Kidney dysfunction reduces the body's ability to clean and filter extra water from your blood, leading to fluid retention and high blood pressure in the early stage. Believe it or not, people with a kidney function of 10% do not show signs of kidney dysfunction and symptoms.

In other words, kidney disease often has no symptoms until at a very advanced stage.
In the US, the leading causes of kidney failure and the end stage of chronic kidney diseases are diabetes and high blood pressure.

Kidney failure or renal failure or end-stage kidney disease is a medical condition in which the kidneys are functioning at less than 15% of normal. 

Acute kidney failure, which develops rapidly and may resolve quickly, is a result of insufficient blood flow to the kidneys such as renal hypertension. These types of kidneys dysfunction can be cured if the causes are found.

Most cases of acute kidney dysfunction may be associated with toxin accumulated in the kidney organs, leading to the condition of nephrotoxicity.

Ficus religiosa or sacred fig is a species of fig belongs to Moraceae, the fig or mulberry family, native to the Indian subcontinent and Indochina.

On finding a potential phytochemical for the prevention and treatment of kidney diseases, researchers elucidated the effects of nephroprotective and curative effects of F. religiosa latex methanol extract against cisplatin-induced acute renal failure.

The study included rats that were divided into five groups.
* Group 1 was administered acacia (2% w/v) of 5 ml/kg throughout the experiment;

* Group 2 was treated with a single dose of cisplatin (5 mg/kg i.p.) on the 1st day;

* Group 3 (200 mg/kg p.o.) of extract control for the 1st to 10th day,

* Group 4 (200 mg/kg p.o.) of extract from the 1st to 10th day and a single dose of cisplatin (5 mg/kg, i.p.) on 11th day while

* Group 5 received the same dose of cisplatin on day 1 and extract (200 mg/kg p.o.) from the 7th to 16th day.

According to the results of the experiment
* The cisplatin-treated group 2 showed significantly reduced renal functions, the changes of biochemical parameters and histopathology in the kidney including increased lipid peroxidation, kidney oxidative stress, and inflammatory markers and reduced levels of antioxidant enzymes.

* However, all parameters were restored back to the near-normal with the 200 mg/kg of extract in the curative and protective groups.

In other words, F. religiosa latex methanol extract showed a strong kidney protective activity against toxicity induced by the cisplatin treatment.

Based on the findings, researchers said, "These findings demonstrated that F. religiosa latex and constituents have excellent nephroprotective and curative activities and thus have great potential as a source for natural health products".
Taken altogether, beta-Sitosterol may be considered a supplement for the prevention of acute kidney toxicity, pending to the confirmation of the larger sample size and multicenter human study.

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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Nephroprotective and curative effects of Ficus religiosa latex extract against cisplatin-induced acute renal failure by Yadav YC1, Srivastava DN. (PubMed)

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