Thursday 6 February 2020

Oleic Acid, A Potential Remedy for the Treatment of Dry Eye

By Kyle J. Norton

Eye diseases are the condition characterized by the change of vision, including a gradual loss of cells in the retina and neurons associated with the loss of vision.

Most eye diseases at the early stage are asymptomatic and painless with no change in the vision until the disease has become quite advanced.

People have an eye problem at one time and another. Most eye conditions are minor and go away sometimes without even noticing.

The most common causes of eye diseases are inflammation as a result of microbial infection, including bacterial, viral, parasitic or fungal infection, eye structure damage due to physical impact, genetic preposition due to mutation of certain associated with the vision, medical conditions such as diabetes and allergens.

According to statistics, approximately one person in three has some form of vision-reducing eye disease by the age of 65 in the US. Age-related macular degeneration (AMD), glaucoma, cataract are the most prevalent eye diseases found in the elderly.

Dry eye is a condition characterized by a lack of quality tears to lubricate and nourish the eye for clear vision.

In other words, dry eye is a condition caused by an imbalance of tear production and drainage or low-quality tear production. The condition is very common in the elderly.

There are certain risk factors that may affect the levels of quality of tears, such as aging (most senior age 65 and over have experience of dry eye), gender (the risk of dry eye is higher in women due to the change of hormone as a result of pregnancy and menopause), medications and long term of use of contact lens.

According to the statistics, in the United States, dry eye affects over 4.88 million Americans age 50 and older. The syndrome is most common in the population of middle-aged or older.

Although it is rare, untreated dry eye or serious dry eye syndrome has been associated with the risk of infection, leading to scarring, thinning, and even perforation of the cornea.

Oleic acid is a phytochemical in the group of Omega-3, 6,9 fatty acids, belongings to the class of Lipids, found abundantly in evening primrose, borage, blackcurrant, etc.

On finding a potential plant that improves eye vision, researchers examined the effect of essential fatty acids (EFAs) as dietary supplements in treating dry-eye for reducing inflammation at the ocular surface.

According to the results of the analysis of the topical application in eye drops to deliver fatty acid (FA, (LA-linoleic acid, ALA-alpha-linolenic acid), OA (oleic acid), and GLA (gamma-linolenic acid)) directly to the ocular surface.
* EFAs or OA in topical ophthalmic preparations can affect the spread and stability of the tear film lipid layer.

* The omega-6 LA (not omega-3 FA) at low concentrations (20 mol%) can be beneficial for enhancing tear stability in dry eye patients.

In other words, out 3 phytochemicals that showed an impact in the treatment of dry eye, only oleic acid exerted a similar effect to those of EFAs.

Taken altogether, OA may be considered a functional fatty acid for the prevention and treatment of dry eye, pending to the confirmation of the larger sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) Evaluation of use of essential fatty acids in topical ophthalmic preparations for dry eye by Mudgil P. (PubMed)

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